Koreaki Matsumoto

Microvascular anastomosis using polyethylene glycol 4000 and fibrin glue.

Rat femoral arteries and veins were anastomosed using fibrin glue and a soluble intravascular stent made of polyethylene glycol 4000 (PEG-4000) with a patency rate of 100%. The anastomoses were strong enough to tolerate a pressure of 250 cm H2O. Histological changes at anastomosed sites and toxicity of PEG-4000 were also examined. With this method, an end-to-end anastomosis can be performed easily and quickly.

Growth‐inhibitory effects of 1,25‐dihydroxyvitamin D3 on normal and psoriatic keratinocytes

The effects of 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3) on the growth and DNA synthesis of cultured human keratinocytes obtained from involved and uninvolved psoriatic epidermis and normal epidermis were studied. Treatment with 10‐8m and 10‐7m of 1,25(OH)2D3 inhibited cell growth as follows: 58.5±19.3% and 21.3±13.6% in normal keratinocytes (n=6); 43.8±22.8% and 17.8±12.3% in psoriatic uninvolved keratinocytes (n=4); 51.7±18.2% and 13.2±6.4% in psoriatic involved keratinocytes (n=6). Inhibition was virtually complete at 10‐6m. DNA synthesis was also inhibited by 10‐8m, 10‐7m and 10‐6m of 1,25(OH)2D3 as follows: 70.0±8.3%, 59.0±6.8% and 16.7±4.0%, respectively, in normal keratinocytes (n=3); 78.5±13.5%, 51.5±25.5% and 24.5±21.5%, respectively, in psoriatic uninvolved keratinocytes (n=2); and 69.3±14.5%, 41.3±19.1% and 14.8±11.2%, respectively, in psoriatic involved keratinocytes (n=4). These results indicate that 1,25(OH)2D3 functions as a growth inhibitor for cultured human keratinocytes derived from both normal and psoriatic skin.

Omental transposition and skin graft in patients for advanced or recurrent breast cancer.

Nine patients, including 4 with primary advanced breast cancer (stage IV) and 5 with local recurrent cancer, underwent chest wall reconstruction using an omental flap and mesh skin grafting. In 2 of these patients the defect of bony chest wall was reconstructed with an acryl-resin plate and omental flap. The postoperative course in all patients was uneventful, except for a slight necrosis on the transposed mesh skin. Flail chest or dypsnea did not occur in those with a bony chest wall reconstruction. The immediate postoperative performans status in 6 of 9 patients and also quality of life improved.

Surgical repair of the congenital ear lobe cleft.

Abstract A surgical procedure using a post-auricular flap is described to reconstruct the particular type of congenital hypoplastic ear lobe cleft associated with soft tissue deficiency. Its advantages are outlined.

Malignant Hemangioendothelioma in Discoid Lupus Erythematosus

A 51‐year‐old gardener developed malignant hemangioendothelioma in a lesion of discoid lupus erythematosus (DLE) after repeated occurrence of squamous cell carcinoma and keratoacanthoma. The hemangioendothelioma arose in the same DLE lesion where squamous cell carcinoma had appeared. It was treated with surgical exision followed by intraveneous dimethyltriazenoimidazole carboxamide (DTIC). He has not shown any signs of recurrence for a follow‐up period of 45 months. This is the first report, to our knowledge, of the occurrence of malignant hemangioendothelioma in a DLE lesion.

Reconstruction of microtia with conchal remnant.

In microtia with conchal remnant (type B microtia), there are various degrees of deformity; consequently, different surgical procedures are required for individual cases. To clarify and simplify these complicated surgical techniques, type B microtia is divided into two types, type BI and type BII, from the standpoint of the emphasis on conchal creation. The methods of treatment are discussed.