Kosei Ohno

Formation and reactivity of dilithiated N-furfurylbenzamides. Synthesis of α-substituted N-furfurylbenzamides

Abstract Dianion 3 can be efficiently and regioselectively generated from N-furfurylbenzamide with lithium diisopropylamide/tetrahydrofuran/−78°C and react with various electrophiles to give α-substituted N-furfurylbenzamide derivatives in good yields.

Photoreaction of 1- and 3-Aralkyl Alicyclic Thioimides: Facile Syntheses of Various Azabicycloalkanes via Norrish Type II Process

Photolysis of the 1-(ω-aralkyl)cyclic thioimides (1b,e,g,h) gave a pair of stereoisomers of 1-azabicycloalkanes (2, 3) in moderate yields. Similarly, in 3-(ω-phenylalkyl)cyclic thioimides (5a-e), a pair of stereoisomers of 2-azabicycloalkanes (6, 7) were obtained

Dopamine Sulfate and the Cardiovascular System

Approximately 80% of the total NE and Ep and 90% of the total DA in circulation consists of conjugated catecholamines (1–3). Kuchel et al (4) reported that increased plasma concentrations of DA-S were observed in patients with essential hypertension. In a recent study (5), we found that the levels of DA-S in the plasma of patients with CHF were 3-fold higher than control values. We also reported that DA-4-S has a positive inotropic effect on isolated rabbit papillary muscles (6). However, the source and physiological role of the sulfate catecholamines remain unknown. In order to investigate the site and the mechanism of action of DA-S, we have synthesized DA-4-S and DA-3-S (Fig.l). The present study was undertaken to determine the affinity for the receptor related to the positive inotropic effect. An attempt was also made to determine the role of sulfate in the conversion of DA-S into free DA and cAMP in various tissues of the rabbit.