Kouji Fujiwara

Effects of Hyperthermia, Radiotherapy and Thermoradiotherapy on Tumor Microvascular Permeability

Morphological changes in rabbit VX‐2 tumor and its vascular permeability to ferritin following hyperthermia, radiotherapy and thermoradiotherapy were investigated by light and electron microscopy. Tumors treated by thermoradiotherapy successively showed a decrease in volume compared with those treated by hyperthermia or radiotherapy. Light microscopically, degenerative or necrotic changes progressed more widely in tumors treated by thermoradiotherapy than in those treated by hyperthermia or radiotherapy alone. When vascular permeability to ferritin was examined, an increase in tumor vascular permeability occurred at 1 day after hyperthermia or thermoradiotherapy, and at 3 days after radiotherapy. These results suggest that the early reaction of tumor microvasculature is a factor contributing to delayed cell death in tumors after thermoradiotherapy or hyperthermia. Acta Pathol Jpn 40: 79–84, 1990.

Mucous-producing cells and ciliated epithelial cells in mandibular radicular cyst: An electron microscopic study

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Proliferative myositis of the buccinator muscle: A case with immunohistochemical and electron microscopic analysis

A case of proliferative myositis of the buccinator muscle is reported. To our knowledge, the present case is the second reported in the oromaxillary region. From immunohistochemical and electron microscopic studies, it seems likely that the ganglion-like cells are derived from myofibroblasts or macrophages rather than from striated muscle cells.

RT1B/D+ Non-Lymphoid DC in Early GVHD and Hg-Induced Autoimmunity of Rat Salivary and Lacrimal Glands

Low dose injections of HgCl2 into Brown Norway (BN), but not other rat strains, are followed by T cell-expansion, resulting in immunopathologic events1. A pathogenetic role of MHC class II-autoreactive T cells was suggested, since T helper cells from Hg-injected BN rats BN(Hg) are able to transfer the immune disease into normal BN2,3. In BN(Hg), lymphocyte infiltrates spontaneously appeared in peripheral tissues, e. g. oral mucosa and salivary glands4,5, which may be related to the (migratory?) properties of the autoreactive T cells. To test this hypothesis, an experimental model, in which activation and proliferation of autoreactive T cells occurs by ways other than chemical induction, would be of interest.

Immunohistochemical and ultrastructural characterization of autoimmune sialoadenitis in aging BDF1 mice

To further the understanding of the immunopathologic mechanisms involved in spontaneous autoimmune sialoadenitis of aging BDF1 mice, immunohistochemical and ultrastructural studies were undertaken. Eighteen of 19 aging BDF1 mice, 23–27 months of age, developed sialoadenitis spontaneously. By light and electron microscopy, it was observed that the submandibular gland lesion was characterized by mononuclear cell infiltration in the periductal and perivascular areas often accompanied by parenchymal destruction. Immunohistochemically, T cells predominated. The ratio of CD4+ to CD8+ T cells ranged from 0.5:1 to 2.9:1, with an average of 1.4:1. It seems likely that not only CD4+ cells, but also CD8+ cells, play a major role in submandibular gland inflammatory reactions of aging BDF1 mice.