Kozo Akasaka
Eisai
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Publication
Featured researches published by Kozo Akasaka.
Xenobiotica | 1994
T. Naitoh; Toru Horie; Satoshi Nagato; Takaki Kagaya; Atsuhiko Kubota; Kozo Akasaka
1. The original drug tested here, (5R)-3-[2-(3-cyanopropyl)benzothiazol-6-yl]-5-methoxymethyl-2-oxaz olidinone (ER-4539), exhibited strong MAO-A inhibitory activity in vitro, but its bioavailability in rat was very low. After ER-4539 was administered orally to dog, a metabolite was found in plasma. 2. The metabolite was isolated by hplc after incubation with dog liver microsomal preparations. Its structure, determined by ms and nmr analysis, was alpha-hydroxy-ER-4539. The configuration of the alpha-hydroxy metabolite was (S), determined in comparison with the authentic sample of (R) and (S) by hplc. The isolated metabolite had potent MAO-A inhibitory action in vitro, indicating that it would have antidepressant action. 3. (5R)-3-[2-((1S)-3-Cyano-1-hydroxypropyl)benzothiazol-6-yl]-5- methoxymethyl-2-oxazolidinone (E2011), the synthesized metabolite, has been improved in regard to biopharmaceutical characteristics in rat and dog.
Archive | 1988
Shinya Abe; Mitsuaki Miyamoto; Masayuki Tanaka; Kozo Akasaka; Kenji Hayashi; Tetsuya Kawahara; Toshi Katayama; Yoshinori Sakuma; Takeshi Suzuki; Isao Yamatsu
Archive | 1995
Kozo Akasaka; Masahiro Yonaga; Akiharu Kajiwara; Kunizo Higurashi; Kohshi Ueno; Satoshi Nagato; Makoto Komatsu; Noritaka Kitazawa; Masataka Ueno; Yoshiharu Yamanishi; Yoshimasa Machida; Yuki Komatsu; Naoyuki Shimomura; Norio Minami; Toshikazu Shimizu; Atsushi Nagaoka
Archive | 1991
Teiji Kimura; Nobuhisa Watanabe; Yasutaka Takase; Kenji Hayashi; Makoto Matsui; Hironori Ikuta; Youji Yamagishi; Kozo Akasaka; Hiroshi Tanaka; Issei Ohtsuka; Takao Saeki; Motoji Kogushi; Tohru Fujimori; Isao Saito
Archive | 1989
Youji Yamagishi; Kozo Akasaka; Takeshi Suzuki; Mitsuaki Miyamoto; Kouji Nakamoto; Kazuo Okano; Shinya Abe; Hironori Ikuta; Kenji Hayashi; Hiroyuki Yoshimura; Tohru Fujimori; Koukichi Harada; Isao Yamatsu
Archive | 1986
Hironori Ikuta; Youji Yamagishi; Kozo Akasaka; Isao Yamatsu; Seiichi Kobayashi; Hiroshi Shirota; Kouichi Katayama
Archive | 1982
Kimiko Hamamura; Kozo Akasaka; Voji Yamagishi
Archive | 1992
Kozo Akasaka; Youichi Iimura; Takaki Kagaya; Akiharu Kajiwara; Mariko Komatsu; Atsuhiko Kubota; Masanori Mizuno; Satoshi Nagato; Atsushi Sasaki; Ichirou Yoshida
Chemical & Pharmaceutical Bulletin | 1999
Kozo Akasaka; Yuki Komatsu; Katsuya Tagami; Toshikazu Shimizu; Naoyuki Shimomura; Hiroshi Naka; Kenji Hayashi; Shigeto Negi
Archive | 1982
Youji Yamagishi; Kozo Akasaka; Kimio Hamamura
