Kozo Shimada

Cylindrical Costal Osteochondral Autograft for Reconstruction of Large Defects of the Capitellum Due to Osteochondritis Dissecans

BACKGROUND There is a need to clarify the usefulness of and problems associated with cylindrical costal osteochondral autograft for reconstruction of large defects of the capitellum due to osteochondritis dissecans. METHODS Twenty-six patients with advanced osteochondritis dissecans of the humeral capitellum were treated with use of cylindrical costal osteochondral autograft. All were males with elbow pain and full-thickness articular cartilage lesions of ≥15 mm in diameter. Clinical, radiographic, and magnetic resonance imaging outcomes were evaluated at a mean follow-up of thirty-six months (range, twenty-four to fifty-one months). RESULTS All patients had rapid functional improvement after treatment with costal osteochondral autograft and returned to their former activities, including sports. Five patients needed additional minor surgical procedures, including screw removal, loose body removal, and shaving of protruded articular cartilage. Mean elbow function, assessed with use of the clinical rating system of Timmerman and Andrews, was 111 points preoperatively and improved to 180 points at the time of follow-up and to 190 points after the five patients underwent the additional operations. Mean elbow motion was 126° of flexion with 16° of extension loss preoperatively and improved to 133° of flexion with 3° of extension loss at the time of follow-up. Osseous union of the graft on radiographs was obtained within three months in all patients. Revascularization of the graft depicted on T1-weighted magnetic resonance imaging and congruity of the reconstructed articular surface depicted on T2-weighted or short tau inversion recovery imaging were assessed at twelve and twenty-four months postoperatively. Functional recovery was good, and all patients were satisfied with the final outcomes. CONCLUSIONS Cylindrical costal osteochondral autograft was useful for the treatment of advanced osteochondritis dissecans of the humeral capitellum. Functional recovery was rapid after surgery. Additional operations were performed for five of the twenty-six patients, whereas the remaining patients showed essentially full recovery within a year. All patients were satisfied with the results at the time of short-term follow-up.

Long-Term Results of Surgery for Forearm Deformities in Patients with Multiple Cartilaginous Exostoses

BACKGROUND Surgical treatment of forearm deformities in patients with multiple cartilaginous exostoses remains controversial. The purpose of the present study was to determine the reasonable indications for operative treatment and to evaluate long-term results of forearm surgery in these patients. METHODS We retrospectively reviewed twenty-three patients (thirty-one forearms) after a mean duration of follow-up of nearly thirteen years. The mean age at the time of the initial procedure was eleven years. The patients underwent a variety of surgical procedures, including excision of exostoses; corrective procedures (lengthening of the radius or ulna and/or corrective osteotomy of the radius and/or ulna) and open reduction or excision of a dislocated radial head. Clinical evaluation involved the assessment of pain, activities of daily living, the cosmetic outcome, and the ranges of motion of the wrist, forearm, and elbow. The radiographic parameters that were assessed were ulnar variance, the radial articular angle, and carpal slip. RESULTS Four patients had mild pain, and five patients had mild restriction of daily activities at the time of follow-up. Eight patients stated that the appearance of the forearm was unsatisfactory. Radiographic parameters (ulnar variance, radial articular angle, carpal slip) were initially improved; however, at the time of the final follow-up visit, the deformities had again progressed and showed no significant improvement. The only procedure that was associated with complications was ulnar lengthening. Complications included nonunion (three forearms), fracture of callus at the site of lengthening (two forearms), and temporary radial nerve paresis following an ulnar distraction osteotomy (one forearm). Excision of exostoses significantly improved the range of pronation (p = 0.036). CONCLUSIONS In our patients with multiple cartilaginous exostoses, corrective osteotomy and/or lengthening of forearm bones was not beneficial. The most beneficial procedure was excision of exostoses. Reasonable indications for forearm surgery in these patients are (1) to improve forearm rotation and (2) to improve the appearance.

Immunohistochemical detection of parathyroid hormone-related peptide, Indian hedgehog, and patched in the process of endochondral ossification in the human

Abstract. Parathyroid hormone-related peptide (PTHrP), Indian hedgehog (Ihh), and patched (Ptc; a receptor for Ihh) were immunolocalized in tissue undergoing endochondral ossification in the human. PTHrP, Ihh, and Ptc were immunolocalized in prehypertrophic and hypertrophic chondrocytes in mature cartilage matrix. PTHrP and Ptc were immunostained in proliferating chondrocytes and perichondrial cells, whereas Ihh was not. PTHrP, Ihh, and Ptc showed positive immunostaining in osteoblasts in the bone-forming area. In the bone resorption site, PTHrP was immunolocalized in osteoclasts, whereas Ihh and Ptc were not. The present findings indicated that PTHrP, Ihh, and Ptc were associated with the process of endochondral ossification, and suggested the possible involvement of Ihh and PTHrP signaling in the regulation of proliferation and hypertrophy of chondrocytes in human chondrogenesis.

Involvement of BMP‐2 signaling in a cartilage cap in osteochondroma

This study describes the distributions of bone morphogenetic protein (BMP)‐2 as well as mRNAs for BMP receptor type IB (BMPRIB), collagen types II (Col II) and III (Col III) in a growing “cartilage cap” of osteochondroma. In situ hybridization and immunohistochemical study were performed using histological sections obtained during surgery. BMP‐2 was detected in mesenchymal cells in the outer fibrous layer and chondrocytes in the inner cartilaginous matrix, positive for Col III and Col II, respectively. BMPRIB mRNA was distributed in chondrocytes. This is the first study to provide observational evidence of the involvement of BMP‐2 signaling in the pathogenesis of cartilage cap of osteochondroma, and suggests the role of BMP‐2 in the growth of cartilage cap in osteochondroma.

The association between cubital tunnel morphology and ulnar neuropathy in patients with elbow osteoarthritis

BACKGROUND Morphologic changes in the cubital tunnel during elbow motion in patients with elbow osteoarthritis have not been examined in vivo. We examined changes in cubital tunnel morphology during elbow motion and characteristics of medial osteophyte development to elucidate whether cubital tunnel area and medial osteophyte size are factors contributing to cubital tunnel syndrome in patients with elbow osteoarthritis. METHODS We performed computed tomography of 13 primary osteoarthritic elbows in patients with cubital tunnel syndrome (group A) and 25 primary osteoarthritic elbows in patients without cubital tunnel syndrome (group B) at full extension, 90° of flexion, and full flexion. Cubital tunnel area, humeral and ulnar osteophyte area, and proportion of osteophytes within the cubital tunnel were analyzed at each position. RESULTS Humeral osteophytes and osteophyte proportion within the cubital tunnel were larger at full flexion (24.7 mm(2) and 49.9% in group A; 18.7 mm(2) and 39% in group B) and 90° of elbow flexion (20.3 mm(2) and 45.3% in group A; 10.2 mm(2) and 30.2% in group B) than at full extension (9.0 mm(2) and 31.3% in group A; 2.3 mm(2) and 12.5% in group B). These parameters were significantly greater in group A than in group B at full extension and 90° of flexion. CONCLUSIONS The effect of medial osteophytes on the ulnar nerve, especially on the humeral side, rather than narrowing of the cubital tunnel, may be a causative factor for cubital tunnel syndrome with elbow osteoarthritis.

Treatment of residual instability and extensor lag in polydactyly of the thumb.

Extensor indicis tendon transfers were used in six cases with residual deformity of the thumb in polydactyly. The indication was extensor lag and instability of the interphalangeal joint. At mean follow-up of three and a half years, normal stability was improved. Full extension was achieved in three cases and two cases also derived some benefits from this operation. Alignment was improved in five cases.

Arthroscopic debridement in the treatment of patients with osteoarthritis of the elbow, based on computer simulation

We retrospectively assessed the value of identifying impinging osteophytes using dynamic computer simulation of CT scans of the elbow in assisting their arthroscopic removal in patients with osteoarthritis of the elbow. A total of 20 patients were treated (19 men and one woman, mean age 38 years (19 to 55)) and followed for a mean of 25 months (24 to 29). We located the impinging osteophytes dynamically using computerised three-dimensional models of the elbow based on CT data in three positions of flexion of the elbow. These were then removed arthroscopically and a capsular release was performed. The mean loss of extension improved from 23° (10° to 45°) pre-operatively to 9° (0° to 25°) post-operatively, and the mean flexion improved from 121° (80° to 140°) pre-operatively to 130° (110° to 145°) post-operatively. The mean Mayo Elbow Performance Score improved from 62 (30 to 85) to 95 (70 to 100) post-operatively. All patients had pain in the elbow pre-operatively which disappeared or decreased post-operatively. According to their Mayo scores, 14 patients had an excellent clinical outcome and six a good outcome; 15 were very satisfied and five were satisfied with their post-operative outcome. We recommend this technique in the surgical management of patients with osteoarthritis of the elbow.

Osteosynthesis for longstanding nonunion of the lateral humeral condyle in adults

HYPOTHESIS Osteosynthesis for longstanding nonunion of the lateral humeral condyle in adults has a high rate of complications, including failure of bony union and restriction of elbow motion. We hypothesized that rigid fixation may contribute to higher union rate and the placement of the condyle fragment with proper tilting may minimize the reduction of elbow motion. MATERIALS AND METHODS Ten patients were treated with osteosynthesis. Average age at operation was 38.6 years. Three patients had dysfunction of the ulnar nerve, 2 experienced pain, and 5 had both presentations. According to Toh et als radiographic criteria, nonunion was categorized as Group 1 in 2 patients and Group 2 in 8 (J Bone Joint Surg Am 2002;84:593-598). We performed osteosynthesis with iliac bone graft and ulnar nerve anterior transposition, with efforts to fix the fragment rigidly and to manage the fragment position properly. RESULTS Osseous union was achieved in all 8 Group 2 patients, while 1 Group 1 case showed delayed union and the other did not achieve union. Pain resolved and ulnar nerve symptoms improved in all cases. In 9 patients with union, total arc of motion was reduced by an average of 20°. The preoperative mobility of the condyle fragment determined by maximum flexion and extension lateral radiographs had a correlation to the postoperative loss of motion (P = .047); however, loss of motion was less than that expected by radiographs. CONCLUSION Osteosynthesis appears to be indicated for Group 2 nonunion with pain. Rigid fixation with care of the position of the fragment is important for the good outcomes.

Kinematic Changes in Elbow Osteoarthritis: In Vivo and 3-Dimensional Analysis Using Computed Tomographic Data

PURPOSE To investigate in vivo 3-dimensional kinematics in elbow osteoarthritis. We hypothesized that normal kinematics is preserved in an osteoarthritic elbow with a normal radiocapitellar joint (OAN). Conversely, we hypothesized that an osteoarthritic elbow with radiocapitellar degenerative changes (OAD) would show an abnormal kinematics pattern. Furthermore, the differences in osteophyte formation between groups may affect elbow kinematics. METHODS We examined 7 normal elbows, 7 OAN elbows, and 9 OAD elbows. We investigated 3-dimensional kinematics using computed tomography registration techniques. The osteophyte location was determined using 3-dimensional bone models generated from computed tomography data. RESULTS The kinematics is different in OAN and OAD elbows. In the OAN group, the ulna changed by 11° from a valgus to a varus position during elbow flexion and demonstrated a 4° change in the axis of elbow motion, similar to that in normal elbows. Osteophytes formed medially on the olecranon fossa. In the OAD group, the ulna changed by 4° varus during flexion from the 90° position, but only by 2° valgus during elbow extension from 90°. The change in the axis of elbow motion was 9°. Additional osteophytes formed on the anteromedial and lateral trochlea, lateral olecranon fossa, and medial olecranon of the ulnotrochlear joint, and on the radiocapitellar joint. CONCLUSIONS Normal kinematics was preserved in the OAN group. The OAD group demonstrated marked changes in the direction of elbow motion in the extension range, and the valgus motion pattern during extension was decreased. CLINICAL RELEVANCE The results of the current study provide a good starting point for further research into the nature of arthritic progression in the elbow joint and the role of debridement arthroplasty.

Anconeus Muscle-Pedicle Bone Graft With Periosteal Coverage for Osteochondritis Dissecans of the Humeral Capitellum

Background: Treatment of advanced osteochondritis dissecans (OCD) of the capitellum is controversial, especially in moderate-sized lesions. Purpose: To establish a treatment algorithm for capitellum OCD, we tried to determine the utility of and problems associated with anconeus muscle-pedicle bone graft with periosteal coverage (ABGP) for the treatment of moderate-sized articular OCD defects of the capitellum. Study Design: Case series; Level of evidence, 4. Methods: According to our protocol for elbow OCD, 16 patients (15 males, 1 female; age range, 12-17 years; mean age, 14.4 years) with a moderate-sized OCD lesion of the humeral capitellum were treated with ABGP. All patients had a full-thickness, unstable OCD lesion that was 10 to 15 mm in diameter. Clinical results and postoperative images, including radiographs and magnetic resonance imaging (MRI), were evaluated at a mean follow-up of 31 months (range, 24-66 months). Results: All but 1 patient had functional improvement after the procedure and returned to previous sporting activities within 6 months. One female patient needed 1 year for functional recovery due to development of postoperative chronic regional pain syndrome (CRPS). Two patients required additional surgery, including shaving of the protruding cartilage, and they returned to their previous level of activity. Mean arc of range of flexion-extension motion was 117° preoperatively and 129° at follow-up (P = .031). Mean elbow function as assessed with the clinical rating system of Timmerman and Andrews was 136 preoperatively and 186 at follow-up (P = .00012). Bony union of the graft as demonstrated by trabecular bone bridging on radiography was obtained within 3 months in all patients. Postoperative MRI was examined for 14 patients at 6 to 12 months after the procedure; the MRIs showed near-normal articular surface integrity in 9 of the 14 patients (64%) and underlying bony structure in 10 of the 14 patients (71%). Conclusion: Improvement after ABGP was obtained within 6 months in all except 1 patient, who developed CRPS. Postoperative radiography and MRI revealed near-normal articular surface integrity or underlying bony structure. This procedure is useful as a surgical option for a moderate-sized articular OCD lesion in the elbow.