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Dive into the research topics where Krasnow Az is active.

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Featured researches published by Krasnow Az.


Clinical Nuclear Medicine | 1998

Detection of osteomyelitis in the neuropathic foot: nuclear medicine, MRI and conventional radiography.

Lipman Bt; Collier Bd; Guillermo F. Carrera; Michael E. Timins; S J Erickson; Jeffrey E. Johnson; Mitchell; Raymond G. Hoffmann; Finger Wa; Krasnow Az; Robert S. Hellman

The diagnostic efficacy of (1) combined three-phase bone scintigraphy and In-111 labeled WBC scintigraphy (Bone/WBC), (2) MRI, and (3) conventional radiography in detecting osteomyelitis of the neuropathic foot was compared. Conventional radiography was comparable to MRI for detection of osteomyelitis. MRI best depicted the presence of osteomyelitis in the forefoot. Particularly in the setting of Charcot joints, Bone/WBC was more specific than conventional radiography or MRI.


Seminars in Nuclear Medicine | 1997

Diagnostic bone scanning in oncology

Krasnow Az; Robert S. Hellman; Michael E. Timins; B. David Collier; Tom Anderson; Isitman At

Over the last several decades bone scanning has been used extensively in the evaluation of oncology patients to detect bone involvement. It can provide information about disease location, prognosis, and the effect of therapy. Bone scanning offers the advantages of whole body evaluation and the detection of lesions earlier than other techniques. However, as newer diagnostic tools become available, indications for bone scanning must be revised and the results combined with these other tests in order to provide optimum patient care. Advances in instrumentation and the subsequent improvement in image quality have allowed nuclear medicine physicians to provide more accurate bone scan interpretations. By optimizing image acquisition, it is often possible to determine lesion characteristics, which are more likely to represent malignancy. Knowledge of disease pathophysiology and other specific properties of the patients primary tumor, along with subsequent correlation of scan abnormalities to patient history, physical examination, previous studies, and other radiological examinations, is essential for determining lesion significance. The differential diagnosis of a scan abnormality should also include consideration of both false normal and abnormal causes. The final interpretation should be clearly communicated to the clinician with appropriate recommendations for further evaluation. Only through careful attention to the patient, the clinician, and appropriate study acquisition parameters will bone scanning maintain its place in the evaluation of oncology patients.


The American Journal of Gastroenterology | 2007

Rapid Gastric Emptying Is More Common than Gastroparesis in Patients With Autonomic Dysfunction

Adeyemi Lawal; Alexandru Barboi; Krasnow Az; Robert Hellman; Safwan Jaradeh; Benson T. Massey

OBJECTIVES:Autonomic dysfunction is associated with a wide variety of gastrointestinal symptoms. It is unclear how many patients with autonomic dysfunction have slow or rapid gastric emptying. The aim of this study was to determine the prevalence of rapid and delayed solid phase gastric emptying in patients with autonomic dysfunction referred for evaluation of gastrointestinal symptoms and the association of emptying rate with clinical symptoms.METHODS:Retrospective review of all patients with autonomic dysfunction who had a gastric emptying test from January, 1996 to March, 2005. Demographic data, clinical symptoms, composite autonomic scoring scale (CASS) score, and gastric emptying parameters were analyzed.RESULTS:Sixty-one subjects (women 49, age 42 [16–74] yr) with autonomic dysfunction were reviewed. Patients had mild-to-moderate (mean CASS score 3) autonomic dysfunction. Twenty-seven, 17, and 17 patients had rapid, normal, and delayed gastric emptying t1/2, respectively. In addition, 10 patients had initially rapid emptying in phase 1, with subsequent slowing in phase 2 to produce an overall normal or delayed t1/2. There was no difference in demographic data or CASS score among the three groups. More patients with initial or overall rapid emptying had diarrhea (70%) compared to patients with normal (33%) or delayed (33%) emptying (P = 0.018).CONCLUSIONS:Unexpectedly, more patients with autonomic dysfunction have rapid rather than delayed gastric emptying. The presence of diarrhea in patients with autonomic symptoms should prompt consideration for the presence of rapid gastric emptying. Conversely, the finding of rapid gastric emptying in patients with gastrointestinal symptoms should prompt consideration for the presence of underlying autonomic dysfunction.


Clinical Nuclear Medicine | 1996

In-111 WBC imaging of osteomyelitis in patients with underlying bone scan abnormalities

A. Kolindou; Liu Y; Kutlan Ozker; Krasnow Az; Isitman At; Robert S. Hellman; Collier Bd

One hundred seven combined In-111 WBC/Tc-99m MDP scans performed on 87 patients with a high clinical suspicion of osteomyelitis were retrospectively reviewed. An 86% sensitivity and a 94% specificity for detecting osteomyelitis were found. In addition, patients were grouped into one of five clinical settings for more detailed analysis: diabetic osteoarthropathy, previous arthroplasty, fracture, overlying skin ulcer, and other etiology. Forty-seven studies were performed while patients received antibiotic therapy without loss of sensitivity for detecting osteomyelitis. Results obtained with scintigraphy compared favorably to other imaging and laboratory studies used to detect osteomyelitis. In conclusion, the combined In-111 WBC/Tc-99m MDP scan is a very sensitive and specific method to detect osteomyelitis in patients with concurrent diabetic osteoarthropathy, fracture, postoperative healing, and overlying skin ulcer. Antibiotic treatment does not appear to adversely affect the sensitivity of these scans.


Clinical Nuclear Medicine | 1992

Increased sacroiliac joint uptake after lumbar fusion and/or laminectomy.

Onsel C; Collier Bd; Kir Km; Larson Sj; Meyer Ga; Krasnow Az; Isitman At; Robert S. Hellman; Guillermo F. Carrera

Of 753 adult patients undergoing SPECT and planar bone scintigraphy for the evaluation of low back pain, 43 (6%) showed either unilateral or bilateral increased sacroiliac joint (SIJ) uptake. Five of the 58 abnormal joints were only identified with SPECT (9%), whereas 20 of the 58 abnormal joints were much more convincingly demonstrated by SPECT (34%). Fifteen of the 43 patients with increased SIJ uptake had undergone prior lumbar laminectomy and/or spinal fusion. Such spinal surgery can increase impact loading on the SIJ, leading to mechanical overload and sacroiliitis. Degenerative joint disease, trauma, or other benign pathology accounted for the remaining patients with increased SIJ uptake. The authors conclude that for patients with a history of lumbar spinal fusion and/or laminectomy, increased SIJ uptake usually is caused by altered spinal mechanics rather than malignancy or infection.


American Heart Journal | 1997

Low dose dobutamine echocardiography is more predictive of reversible dysfunction after acute myocardial infarction than resting single photon emission computed tomographic thallium-201 scintigraphy

Steven C. Smart; Thomas R. Stoiber; Robert Hellman; John Duchak; John C. Wynsen; Mehmet Kitapci; Isitman At; Krasnow Az; B. David Collier; Kiran B. Sagar

To directly compare dobutamine echocardiography and resting single photon emission computed tomographic (SPECT) thallium-201 (Tl-201) scintigraphy for the detection of reversible dysfunction, 64 patients underwent dobutomine echocardiography (baseline, low dose 5 and 10 mg/kg/min, and peak dose), rest Tl-201 scintigraphy (3 mCi - 15 minute and 3- to 4-hour SPECT imaging), and coronary angiography during the first week after acute myocardial infarction. Follow-up echocardiography was performed 4 to 8 weeks after discharge. Wall thickening improved at follow-up in 52% (207 of 399) of the dysfunctional segments. By receiver operating characteristic analysis, biphasic responses and sustained improvement during dobutamine echocardiography were more accurate (p < 0.01) than Tl-201 uptake by SPECT scintigraphy for reversible dysfunction. The greater accuracy of dobutamine echocardiography resulted from higher accuracy in akinetic segments, Q wave infarction, and multivessel coronary artery disease. In conclusion, dobutamine echocardiography was more accurate than resting SPECT Tl-201 scintigraphy for reversible dysfunction after acute myocardial infarction.


Clinical Nuclear Medicine | 1988

False-negative bone imaging due to etidronate disodium therapy

Krasnow Az; Collier Bd; Isitman At; Robert S. Hellman; Ewey D

A 77-year-old man wilh prostate cancer was serially evaluated for bone metastases using Tc-99m methylene disphosphonate (Tc-99m MOP) both on and off treatment with etidronate disodium (EHDP). While the patient was receiving the medication only minimal bony uptake ot the tracer was seen with the majority remaining in the soft tissues. The similarly structured EHDP probably saturated the binding sites that the radioactive MDP usually adheres to. Physicians should be aware of this interaction and may have to wait until the EHDP has been discontinued for several months before performing bone imaging on these patients.


Clinical Nuclear Medicine | 1991

Concentration of Tc-99m MDP in ovarian carcinoma and its soft tissue metastases.

Beres Ra; Patel N; Krasnow Az; Isitman At; Robert S. Hellman; Purushotham Veluvolu; Patillo Rs; Collier Bd

A patient with ovarian carcinoma was evaluated for skeletal metastasis with a routine whole body bone scan. Although no bone metastases were visualized, there was dramatic accumulation of tracer in the soft tissues of the abdomen. CT revealed calcifying soft tissue metastases on the liver surface, the bowel serosa, and in the pelvis corresponding to the abnormal areas of Tc-99m MDP uptake. Tumor necrosis and ongoing calcification within the metastatic sites are possible explanations for this unusual soft tissue concentration of the bone-seeking radiopharmaceutical. In patlents with meatastatic ovarian carcinoma, careful review of extraosseous regions on bone scan images may provide valuable diagnostic information.


Clinical Nuclear Medicine | 1992

High-resolution bone scintigraphy of the adult wrist

Patel N; B. David Collier; Guillermo F. Carrera; Douglas P. Hanel; James R. Sanger; Hani S. Matloub; Donald A. Hackbarth; Krasnow Az; Robert S. Hellman; Isitman At

Bony anatomic landmarks of the wrist (e.g., pisiform, hook of hamate, radioulnar joint, and styloid processes of the radius and ulna) were routinely identified in 28 adult patients examined for wrist pain. With the wrists prone and immobilized, bone scintigrams were obtained for 500,000 counts with an asymmetric (133 to 161 keV) Tc-99m energy window and either a converging (best choice) or straight-bore, high-resolution collimator. High-resolution scintigraphy precisely localized degenerative joint disease (nine patients), scaphoid fractures (five), pisiform fracture (one), lunate avascular necrosis (one), radioulnar arthritis (one), septic or inflammatory arthritis (six), ulnocarpal impingement (two), and reflex sympathetic dystrophy syndrome (two). Images obtained palm down with the wrist in ulnar deviation helped identify increased uptake within the scaphoid. Fracture and significant bone or joint disease were excluded in one patient.


Seminars in Nuclear Medicine | 1988

The clinical significance of unusual sites of thallium-201 uptake

Robert C. Stadalnik; Krasnow Az; B. David Collier; Isitman At; Robert S. Hellman; David C. Peck

C U R R E N T L Y , Thallium-201 (2~ is the major radionuclide for myocardial perfusion imaging. To a lesser extent it is also used for the detection of parathyroid adenoma and hyperplasia. In addition thyroid and pulmonary malignancies, as well as various brain tumors have been studied with =~ Two instructive cases of extra cardiac 2~ uptake are presented in this report. Isitman, Robert S. Hellman, and David C. Peck

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Isitman At

Medical College of Wisconsin

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Robert S. Hellman

Medical College of Wisconsin

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Collier Bd

Medical College of Wisconsin

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B. David Collier

Medical College of Wisconsin

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Guillermo F. Carrera

Medical College of Wisconsin

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Kutlan Ozker

Medical College of Wisconsin

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Patel N

Medical College of Wisconsin

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William T. Pochis

Medical College of Wisconsin

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David C. Peck

Medical College of Wisconsin

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