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Featured researches published by Krista Vandenborne.


Journal of Bone and Joint Surgery, American Volume | 2005

Early Quadriceps Strength Loss After Total Knee Arthroplasty: The Contributions of Muscle Atrophy and Failure of Voluntary Muscle Activation

Ryan L. Mizner; Stephanie C. Petterson; Jennifer E. Stevens; Krista Vandenborne; Lynn Snyder-Mackler

BACKGROUND While total knee arthroplasty reduces pain and provides a functional range of motion of the knee, quadriceps weakness and reduced functional capacity typically are still present one year after surgery. The purpose of the present investigation was to determine the role of failure of voluntary muscle activation and muscle atrophy in the early loss of quadriceps strength after surgery. METHODS Twenty patients with unilateral knee osteoarthritis were tested an average of ten days before and twenty-seven days after primary total knee arthroplasty. Quadriceps strength and voluntary muscle activation were measured with use of a burst-superimposition technique in which a supramaximal burst of electrical stimulation is superimposed on a maximum voluntary isometric contraction. Maximal quadriceps cross-sectional area was assessed with use of magnetic resonance imaging. RESULTS Postoperatively, quadriceps strength was decreased by 62%, voluntary activation was decreased by 17%, and maximal cross-sectional area was decreased by 10% in comparison with the preoperative values; these differences were significant (p < 0.01). Collectively, failure of voluntary muscle activation and atrophy explained 85% of the loss of quadriceps strength (p < 0.001). Multiple linear regression analysis revealed that failure of voluntary activation contributed nearly twice as much as atrophy did to the loss of quadriceps strength. The severity of knee pain with muscle contraction did not change significantly compared with the preoperative level (p = 0.31). Changes in knee pain during strength-testing did not account for a significant amount of the change in voluntary activation (p = 0.14). CONCLUSIONS Patients who are managed with total knee arthroplasty have profound impairment of quadriceps strength one month after surgery. This impairment is predominantly due to failure of voluntary muscle activation, and it is also influenced, to a lesser degree, by muscle atrophy. Knee pain with muscle contraction played a surprisingly small role in the reduction of muscle activation.


Multiple Sclerosis Journal | 2004

Resistance training improves strength and functional capacity in persons with multiple sclerosis

Lesley J. White; Sean C. McCoy; Vanessa Castellano; Gregory M. Gutierrez; Jennifer E. Stevens; Glenn A. Walter; Krista Vandenborne

The purpose of this study was to evaluate the effect of an eight-week progressive resistance training programme on lower extremity strength, ambulatory function, fatigue and self-reported disability in multiple sclerosis (MS) patients (mean disability score 3.79-0.8). Eight MS subjects volunteered for twice weekly training sessions. During the first two weeks, subjects completed one set of 8 -10 reps at 50% of maximal voluntary contraction (MVC) of knee flexion, knee extension and plantarflexion exercises. In subsequent sessions, the subjects completed one set of 10 -15 repetitions at 70% of MVC. The resistance was increased by 2 -5% when subjects completed 15 repetitions in consecutive sessions. Isometric strength of the quadriceps, hamstring, plantarflexor and dorsiflexor muscle groups was assessed before and after the training programme using an isokinetic dynamometer. Magnetic resonance images of the thigh were acquired before and after the exercise programme as were walking speed (25-ft), number of steps in 3 min, and self-reported fatigue and disability. Knee extension (7.4%), plantarflexion (52%) and stepping performance (8.7%) increased significantly (PB-0.05). Self-reported fatigue decreased (PB-0.05) and disability tended to decrease (P -0.07) following the training programme. MS patients are capable of making positive adaptations to resistance training that are associated with improved ambulation and decreased fatigue.


Anesthesiology | 2008

Ambulatory continuous femoral nerve blocks decrease time to discharge readiness after tricompartment total knee arthroplasty: a randomized, triple-masked, placebo-controlled study.

Brian M. Ilfeld; Linda T. Le; R. Scott Meyer; Edward R. Mariano; Krista Vandenborne; Pamela W. Duncan; Daniel I. Sessler; F. Kayser Enneking; Jonathan J. Shuster; Douglas W. Theriaque; Linda F. Berry; Eugene H. Spadoni; Peter F. Gearen

Background:The authors tested the hypotheses that, compared with an overnight continuous femoral nerve block (cFNB), a 4-day ambulatory cFNB increases ambulation distance and decreases the time until three specific readiness-for-discharge criteria are met after tricompartment total knee arthroplasty. Methods:Preoperatively, all patients received a cFNB (n = 50) and perineural ropivacaine 0.2% from surgery until the following morning, at which time they were randomly assigned to either continue perineural ropivacaine or switch to perineural normal saline. Primary endpoints included (1) time to attain three discharge criteria (adequate analgesia, independence from intravenous analgesics, and ambulation of at least 30 m) and (2) ambulatory distance in 6 min the afternoon after surgery. Patients were discharged with their cFNB and a portable infusion pump, and catheters were removed on postoperative day 4. Results:Patients given 4 days of perineural ropivacaine attained all three discharge criteria in a median (25th–75th percentiles) of 25 (21–47) h, compared with 71 (46–89) h for those of the control group (estimated ratio, 0.47; 95% confidence interval, 0.32–0.67; P <0.001). Patients assigned to receive ropivacaine ambulated a median of 32 (17–47) m the afternoon after surgery, compared with 26 (13–35) m for those receiving normal saline (estimated ratio, 1.21; 95% confidence interval, 0.71–1.85; P = 0.42). Conclusions:Compared with an overnight cFNB, a 4-day ambulatory cFNB decreases the time to reach three important discharge criteria by an estimated 53% after tricompartment total knee arthroplasty. However, the extended infusion did not increase ambulation distance the afternoon after surgery. (ClinicalTrials.gov No. NCT00135889.)


Anesthesiology | 2006

Ambulatory continuous interscalene nerve blocks decrease the time to discharge readiness after total shoulder arthroplasty: a randomized, triple-masked, placebo-controlled study.

Brian M. Ilfeld; Krista Vandenborne; Pamela W. Duncan; Daniel I. Sessler; F. Kayser Enneking; Jonathan J. Shuster; Douglas W. Theriaque; Terese L. Chmielewski; Eugene H. Spadoni; Thomas W. Wright

Background:A continuous interscalene nerve block (CISB) may be used to provide analgesia after shoulder arthroplasty. Therefore, inpatient stays may be shortened if CISB (1) provides adequate analgesia without intravenous opioids and (2) improves shoulder mobilization. This study investigated the relationship between ambulatory CISB and the time to reach three discharge criteria after shoulder arthroplasty. Methods:Preoperatively, patients received a CISB. All patients received a perineural 0.2% ropivacaine infusion from surgery until 06:00 the following morning, at which time they were randomly assigned either to continue perineural ropivacaine or to switch to normal saline. The primary endpoint was the time from the end of surgery until three discharge criteria were attained (adequate analgesia, independence from intravenous analgesics, and tolerance to 50% of shoulder motion targets). Patients were discharged home as early as the afternoon after surgery with their CISB using a portable infusion pump. Results:Patients receiving perineural ropivacaine (n = 16) attained all three discharge criteria in a median (10th–90th percentiles) of 21 (16–41) h, compared with 51 (37–90) h for those receiving perineural normal saline (n = 13, P < 0.001). Unlike patients receiving perineural ropivacaine, patients receiving perineural normal saline often required intravenous morphine, but still experienced a higher degree of pain and tolerated less external rotation. Conclusions:An ambulatory CISB considerably decreases the time until readiness for discharge after shoulder arthroplasty, primarily by providing potent analgesia that permits greater passive shoulder movement and the avoidance of intravenous opioids. Additional research is required to define the appropriate subset of patients and assess the incidence of complications associated with earlier discharge.


Muscle & Nerve | 1998

Longitudinal study of skeletal muscle adaptations during immobilization and rehabilitation.

Krista Vandenborne; Mark A. Elliott; Glenn A. Walter; Sadi Abdus; Enyi Okereke; Michael Shaffer; David Tahernia; John L. Esterhai

This study describes the metabolic, morphologic, neurologic, and functional adaptations observed in the plantar flexors during 8 weeks of lower leg immobilization and 10 weeks of physical therapy following ankle surgery. A combination of magnetic resonance imaging and spectroscopy, isokinetic and isometric muscle testing, and simple functional tests revealed many adaptive changes due to immobilization, including atrophy, loss of muscle strength, reduced central activation, increase in fatigue resistance, and an increase in inorganic phosphate content. After 10 weeks of physical therapy all alterations were reversed, with the exception of a remaining 5.5% deficit in total muscle cross‐sectional area.


The Journal of Physiology | 1999

In vivo ATP synthesis rates in single human muscles during high intensity exercise

Glenn A. Walter; Krista Vandenborne; Mark A. Elliott; John S. Leigh

1 In vivo ATP synthesis rates were measured in the human medial gastrocnemius muscle during high intensity exercise using localized 31P‐magnetic resonance spectroscopy (31P‐MRS). Six‐second localized spectra were acquired during and following a 30 s maximal voluntary rate exercise using a magnetic resonance image‐guided spectral localization technique. 2 During 30 s maximal voluntary rate exercise, ATPase fluxes were predominantly met by anaerobic ATP sources. Maximal in vivo glycogenolytic rates of 207 ± 48 mM ATP min−1 were obtained within 15 s, decreasing to 72 ± 34 mM ATP min−1 by the end of 30 s. In contrast, aerobic ATP synthesis rates achieved 85 ± 2 % of their maximal capacity within 9 s and did not change throughout the exercise. The ratio of peak glycolytic ATP synthesis rate to maximal oxidative ATP synthesis was 2.9 ± 0.9. 3 The non‐Pi, non‐CO2 buffer capacity was calculated to be 27.0 ± 6.2 slykes (millimoles acid added per unit change in pH). At the cessation of exercise, Pi, phosphomonoesters and CO2 were predicted to account for 17.2 ± 1.5, 5.57 ± 0.97 and 2.24 ± 0.34 slykes of the total buffer capacity. 4 Over the approximately linear range of intracellular pH recovery following the post‐exercise acidification, pHi recovered at a rate of 0.19 ± 0.03 pH units min−1. Proton transport capacity was determined to be 16.4 ± 4.1 mM (pH unit)−1 min−1 and corresponded to a maximal proton efflux rate of 15.3 ± 2.7 mM min−1. 5 These data support the observation that glycogenolytic and glycolytic rates are elevated in vivo in the presence of elevated Pi levels. The data do not support the hypothesis that glycogenolysis follows Michealis‐Menten kinetics with an apparent Km for [Pi]in vivo. 6 In vivo ‐measured ATP utilization rates and the initial dependence on PCr and glycolysis were similar to those previously reported in in situ studies involving short duration, high intensity exercise. This experimental approach presents a non‐invasive, quantitative measure of peak glycolytic rates in human skeletal muscle.


Anesthesiology | 2008

Ambulatory Continuous Posterior Lumbar Plexus Nerve Blocks after Hip Arthroplasty : A Dual-center, Randomized, Triple-masked, Placebo-controlled Trial

Brian M. Ilfeld; Scott T. Ball; Peter F. Gearen; Linda T. Le; Edward R. Mariano; Krista Vandenborne; Pamela W. Duncan; Daniel I. Sessler; F. Kayser Enneking; Jonathan J. Shuster; Douglas W. Theriaque; R. Scott Meyer

Background:The authors tested the hypotheses that after hip arthroplasty, ambulation distance is increased and the time required to reach three specific readiness-for-discharge criteria is shorter with a 4-day ambulatory continuous lumbar plexus block (cLPB) than with an overnight cLPB. Methods:A cLPB consisting of 0.2% ropivacaine was provided from surgery until the following morning. Patients were then randomly assigned either to continue ropivacaine or to be switched to normal saline. Primary endpoints included (1) time to attain three discharge criteria (adequate analgesia, independence from intravenous analgesics, and ambulation ≥ 30 m) and (2) ambulatory distance in 6 min the afternoon after surgery. Patients were discharged with their cLPB and a portable infusion pump, and catheters were removed on the fourth postoperative day. Results:Patients given 4 days of perineural ropivacaine (n = 24) attained all three discharge criteria in a median (25th–75th percentiles) of 29 (24–45) h, compared with 51 (42–73) h for those of the control group (n = 23; estimated ratio = 0.62; 95% confidence interval, 0.45–0.92; P = 0.011). Patients assigned to receive ropivacaine ambulated a median of 34 (9–55) m the afternoon after surgery, compared with 20 (6–46) m for those receiving normal saline (estimated ratio = 1.3; 95% confidence interval, 0.6–3.0; P = 0.42). Three falls occurred in subjects receiving ropivacaine (13%), versus none in subjects receiving normal saline. Conclusions:Compared with an overnight cLPB, a 4-day ambulatory cLPB decreases the time to reach three predefined discharge criteria by an estimated 38% after hip arthroplasty. However, the extended infusion did not increase ambulation distance to a statistically significant degree.


The American Journal of Medicine | 1998

Autonomic testing in patients with chronic fatigue syndrome

Pascale De Becker; Paul Dendale; Kenny De Meirleir; Isabelle Campine; Krista Vandenborne; Yves Hagers

The purpose of this study was to determine whether chronic fatigue syndrome (CFS) patients show autonomic dysfunction at the cardiac level and if so, to discover whether these abnormalities explain the fatiguability and/or other symptoms in CFS. The study population consisted of 21 CFS patients (Centers for Disease Control and Prevention [CDC] criteria, 1988) and 13 age- and sex-matched healthy controls. The autonomic testing consisted of: (1) postural challenge: registration of heart rate and blood pressure (BP) and heart rate variability in supine and in upright position (tilted to 70 degrees); (2) Valsalva maneuver; (3) handgrip test; (4) cold pressor test; and (5) heart rate response to deep breathing. Statistical analysis was performed using the Mann Whitney rank sum test; results of the test were considered significant at the 0.05 level. After tilting heart rate was significantly higher in CFS patients compared with healthy controls (mean CFS = 88.9 beats/min vs control = 77.9 beats/min; P <0.01). Low frequency power after tilting was significantly higher in CFS patients compared with controls (mean CFS = 0.603 vs control = 0.428; P = 0.02). There was a trend toward an increased heart rate during the cold pressor test. Other parameters did not differ between the CFS and control populations. The observed changes point toward a sympathetic overactivity in CFS patients when they are exposed to stress. Parasympathetic abnormalities could not be observed. Therefore, our findings provide no real explanation for the fatigue and intolerance to physical exertion in these patients.


NMR in Biomedicine | 2013

T₂ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.

Ishu Arpan; Sean C. Forbes; Donovan J. Lott; Claudia Senesac; Michael J. Daniels; William Triplett; Jasjit Deol; H. Lee Sweeney; Glenn A. Walter; Krista Vandenborne

Skeletal muscles of children with Duchenne muscular dystrophy (DMD) show enhanced susceptibility to damage and progressive lipid infiltration, which contribute to an increase in the MR proton transverse relaxation time (T2). Therefore, the examination of T2 changes in individual muscles may be useful for the monitoring of disease progression in DMD. In this study, we used the mean T2, percentage of elevated pixels and T2 heterogeneity to assess changes in the composition of dystrophic muscles. In addition, we used fat saturation to distinguish T2 changes caused by edema and inflammation from fat infiltration in muscles. Thirty subjects with DMD and 15 age‐matched controls underwent T2‐weighted imaging of their lower leg using a 3‐T MR system. T2 maps were developed and four lower leg muscles were manually traced (soleus, medial gastrocnemius, peroneal and tibialis anterior). The mean T2 of the traced regions of interest, width of the T2 histograms and percentage of elevated pixels were calculated. We found that, even in young children with DMD, lower leg muscles showed elevated mean T2, were more heterogeneous and had a greater percentage of elevated pixels than in controls. T2 measures decreased with fat saturation, but were still higher (P < 0.05) in dystrophic muscles than in controls. Further, T2 measures showed positive correlations with timed functional tests (r = 0.23–0.79). The elevated T2 measures with and without fat saturation at all ages of DMD examined (5–15 years) compared with unaffected controls indicate that the dystrophic muscles have increased regions of damage, edema and fat infiltration. This study shows that T2 mapping provides multiple approaches that can be used effectively to characterize muscle tissue in children with DMD, even in the early stages of the disease. Therefore, T2 mapping may prove to be clinically useful in the monitoring of muscle changes caused by the disease process or by therapeutic interventions in DMD. Copyright


Anesthesia & Analgesia | 2006

Total knee arthroplasty as an overnight-stay procedure using continuous femoral nerve blocks at home : A prospective feasibility study

Brian M. Ilfeld; Peter F. Gearen; F. Kayser Enneking; Linda F. Berry; Eugene H. Spadoni; Steven Z. George; Krista Vandenborne

The average duration of hospitalization after total knee arthroplasty (TKA) in the United States is 4–5 days. In this two-phase study we investigated the feasibility of converting TKA into an overnight-stay procedure using a continuous femoral nerve block provided at home through postoperative day 4. Nine of 10 patients met discharge criteria and were discharged home the day after surgery. Pain was well controlled, opioid requirements and sleep disturbances were minimal, and patient satisfaction was high. Additional research is required to replicate these results in a controlled trial, define the appropriate subset of patients, and assess the incidence of complications associated with this practice before its mainstream use.

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Sean C. Forbes

Lawson Health Research Institute

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Chris M. Gregory

Medical University of South Carolina

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Min Liu

University of Florida

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