Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Kristin E. Rosner is active.

Publication


Featured researches published by Kristin E. Rosner.


Bioorganic & Medicinal Chemistry Letters | 2010

The discovery of novel tartrate-based TNF-[alpha] converting enzyme (TACE) inhibitors

Kristin E. Rosner; Zhuyan Guo; Peter Orth; Gerald W. Shipps; David B. Belanger; Tin Yau Chan; Patrick J. Curran; Chaoyang Dai; Yongqi Deng; Vinay M. Girijavallabhan; Liwu Hong; Brian J. Lavey; Joe F. Lee; Dansu Li; Zhidan Liu; Janeta Popovici-Muller; Pauline C. Ting; Henry A. Vaccaro; Li Wang; Tong Wang; Wensheng Yu; Guowei Zhou; Xiaoda Niu; Jing Sun; Joseph A. Kozlowski; Daniel Lundell; Vincent Madison; Brian Mckittrick; John J. Piwinski; Neng Yang Shih

A novel series of TNF-alpha convertase (TACE) inhibitors which are non-hydroxamate have been discovered. These compounds are bis-amides of L-tartaric acid (tartrate) and coordinate to the active site zinc in a tridentate manner. They are selective for TACE over other MMPs. We report the first X-ray crystal structure for a tartrate-based TACE inhibitor.


Bioorganic & Medicinal Chemistry Letters | 2009

Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase.

Janeta Popovici-Muller; Gerald W. Shipps; Kristin E. Rosner; Yongqi Deng; Tong Wang; Patrick J. Curran; Meredith A. Brown; M. Arshad Siddiqui; Alan B. Cooper; Jose S. Duca; Michael Cable; Viyyoor M. Girijavallabhan

The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives.


Bioorganic & Medicinal Chemistry Letters | 2009

Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase

Yongqi Deng; Gerald W. Shipps; Tong Wang; Janeta Popovici-Muller; Kristin E. Rosner; M. Arshad Siddiqui; Jose S. Duca; Alan B. Cooper; Michael Cable

A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase. A number of these compounds exhibited potent activity in enzymatic assay. The synthesis and structure-activity relationship are also described.


Archive | 2003

Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents

Gerald W. Shipps; Kristin E. Rosner; Janeta Popovici-Muller; Yongqi Deng; Tong Wang; Patrick J. Curran


International Journal of Mass Spectrometry | 2004

An affinity selection-mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: Discovery of a novel antagonist of E. coli dihydrofolate reductase

D. Allen Annis; John Athanasopoulos; Patrick J. Curran; Jason S. Felsch; Krishna Kalghatgi; William H. Lee; Huw M. Nash; Jean Paul A. Orminati; Kristin E. Rosner; Gerald W. Shipps; G. R.A. Thaddupathy; Andrew N. Tyler; Lev Vilenchik; Carston R. Wagner; Edward A. Wintner


Archive | 2005

Chemical compounds and pharmaceutical compositions containing them for the treatment of inflammatory disorders

Zhuyan Guo; Peter Orth; Zhaoning Zhu; Robert D. Mazzola; Tin Yau Chan; Henry A. Vaccaro; Kittrick Brian Mc; Joseph A. Kozlowski; Brian J. Lavey; Guowei Zhou; Sunil Paliwal; Shing-Chun Wong; Neng-Yang Shih; Pauline C. Ting; Kristin E. Rosner; Gerald W. Shipps; M. Arshad Siddiqui; David B. Belanger; Chaoyang Dai; Dansu Li; Vinay M. Girijavallabhan; Janeta Popovici-Muller; Wensheng Yu; Lianyun Zhao


Bioorganic & Medicinal Chemistry Letters | 2005

Aminothiazole inhibitors of HCV RNA polymerase

Gerald W. Shipps; Yongqi Deng; Tong Wang; Janeta Popovici-Muller; Patrick J. Curran; Kristin E. Rosner; Alan B. Cooper; Viyyoor M. Girijavallabhan; Nancy Butkiewicz; Michael Cable


Archive | 2001

Methods for forming combinatorial libraries combining amide bond formation with epoxide opening

Gerald W. Shipps; Kristin E. Rosner; Gergely M. Makara; Edward A. Wintner; Huw M. Nash; Jason S. Felsch; Kollol Pal; George R. Lenz


Archive | 2010

Modulatoren von zellzyklus-kontrollpunkten und ihre verwendung in kombination mit kontrollpunkt-kinasehemmern

Janeta Popovici-Muller; Kristin E. Rosner; Timothy J. Guzi


Archive | 2010

Modulateurs de points de contrôle du cycle cellulaire et leur utilisation en combinaison avec des inhibiteurs de kinase de point de contrôle

Janeta Popovici-Muller; Kristin E. Rosner; Timothy J. Guzi

Collaboration


Dive into the Kristin E. Rosner's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge