Kristin E. Rosner
Schering-Plough
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Publication
Featured researches published by Kristin E. Rosner.
Bioorganic & Medicinal Chemistry Letters | 2010
Kristin E. Rosner; Zhuyan Guo; Peter Orth; Gerald W. Shipps; David B. Belanger; Tin Yau Chan; Patrick J. Curran; Chaoyang Dai; Yongqi Deng; Vinay M. Girijavallabhan; Liwu Hong; Brian J. Lavey; Joe F. Lee; Dansu Li; Zhidan Liu; Janeta Popovici-Muller; Pauline C. Ting; Henry A. Vaccaro; Li Wang; Tong Wang; Wensheng Yu; Guowei Zhou; Xiaoda Niu; Jing Sun; Joseph A. Kozlowski; Daniel Lundell; Vincent Madison; Brian Mckittrick; John J. Piwinski; Neng Yang Shih
A novel series of TNF-alpha convertase (TACE) inhibitors which are non-hydroxamate have been discovered. These compounds are bis-amides of L-tartaric acid (tartrate) and coordinate to the active site zinc in a tridentate manner. They are selective for TACE over other MMPs. We report the first X-ray crystal structure for a tartrate-based TACE inhibitor.
Bioorganic & Medicinal Chemistry Letters | 2009
Janeta Popovici-Muller; Gerald W. Shipps; Kristin E. Rosner; Yongqi Deng; Tong Wang; Patrick J. Curran; Meredith A. Brown; M. Arshad Siddiqui; Alan B. Cooper; Jose S. Duca; Michael Cable; Viyyoor M. Girijavallabhan
The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives.
Bioorganic & Medicinal Chemistry Letters | 2009
Yongqi Deng; Gerald W. Shipps; Tong Wang; Janeta Popovici-Muller; Kristin E. Rosner; M. Arshad Siddiqui; Jose S. Duca; Alan B. Cooper; Michael Cable
A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase. A number of these compounds exhibited potent activity in enzymatic assay. The synthesis and structure-activity relationship are also described.
Archive | 2003
Gerald W. Shipps; Kristin E. Rosner; Janeta Popovici-Muller; Yongqi Deng; Tong Wang; Patrick J. Curran
International Journal of Mass Spectrometry | 2004
D. Allen Annis; John Athanasopoulos; Patrick J. Curran; Jason S. Felsch; Krishna Kalghatgi; William H. Lee; Huw M. Nash; Jean Paul A. Orminati; Kristin E. Rosner; Gerald W. Shipps; G. R.A. Thaddupathy; Andrew N. Tyler; Lev Vilenchik; Carston R. Wagner; Edward A. Wintner
Archive | 2005
Zhuyan Guo; Peter Orth; Zhaoning Zhu; Robert D. Mazzola; Tin Yau Chan; Henry A. Vaccaro; Kittrick Brian Mc; Joseph A. Kozlowski; Brian J. Lavey; Guowei Zhou; Sunil Paliwal; Shing-Chun Wong; Neng-Yang Shih; Pauline C. Ting; Kristin E. Rosner; Gerald W. Shipps; M. Arshad Siddiqui; David B. Belanger; Chaoyang Dai; Dansu Li; Vinay M. Girijavallabhan; Janeta Popovici-Muller; Wensheng Yu; Lianyun Zhao
Bioorganic & Medicinal Chemistry Letters | 2005
Gerald W. Shipps; Yongqi Deng; Tong Wang; Janeta Popovici-Muller; Patrick J. Curran; Kristin E. Rosner; Alan B. Cooper; Viyyoor M. Girijavallabhan; Nancy Butkiewicz; Michael Cable
Archive | 2001
Gerald W. Shipps; Kristin E. Rosner; Gergely M. Makara; Edward A. Wintner; Huw M. Nash; Jason S. Felsch; Kollol Pal; George R. Lenz
Archive | 2010
Janeta Popovici-Muller; Kristin E. Rosner; Timothy J. Guzi
Archive | 2010
Janeta Popovici-Muller; Kristin E. Rosner; Timothy J. Guzi