Kristin Lundy DeMello

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Featured researches published by Kristin Lundy DeMello.

Bioorganic & Medicinal Chemistry Letters | 2006

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog

Subas M. Sakya; Kristin Lundy DeMello; Martha L. Minich; Bryson Rast; Andrei Shavnya; Robert J. Rafka; David A. Koss; Hengmiao Cheng; Jin Li; Burton H. Jaynes; Carl Bernard Ziegler; Donald W. Mann; Carol F. Petras; Scott B. Seibel; Annette M. Silvia; David M. George; Lisa A. Lund; Suzanne H. St. Denis; Anne Hickman; Michelle L. Haven; Michael P. Lynch

Bioorganic & Medicinal Chemistry Letters | 2006

Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors.

Hengmiao Cheng; Kristin Lundy DeMello; Jin Li; Subas M. Sakya; Kazuo Ando; Kiyoshi Kawamura; Tomoki Kato; Robert J. Rafka; Burton H. Jaynes; Carl Bernard Ziegler; Rod Stevens; Lisa A. Lund; Donald W. Mann; Carolyn Rose Kilroy; Michelle L. Haven; Erik L. Nimz; Jason K. Dutra; Chao Li; Martha L. Minich; Nicole L. Kolosko; Carol F. Petras; Annette M. Silvia; Scott B. Seibel

Archive | 2003

Cox-2 selective carprofen for treating pain and inflammation in dogs

Kristin Lundy DeMello; Anthony Paul Ricketts

Bioorganic & Medicinal Chemistry Letters | 2004

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.

Jin Li; Kristin Lundy DeMello; Henry Cheng; Subas M. Sakya; Brian Scott Bronk; Robert J. Rafka; Burton H. Jaynes; Carl Bernard Ziegler; Carolyn Rose Kilroy; Donald W. Mann; Eric L. Nimz; Michael P. Lynch; Michelle L. Haven; Nicole L. Kolosko; Martha L. Minich; Chao Li; Jason K. Dutra; Bryson Rast; Rhonda Marie Crosson; Barry James Morton; Glen W. Kirk; Kathleen M. Callaghan; David A. Koss; Andrei Shavnya; Lisa A. Lund; Scott B. Seibel; Carol F. Petras; Annette M. Silvia

Bioorganic & Medicinal Chemistry Letters | 2007

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1 -(5 -methylsulfonyl )pyrid -2 -yl and 4-nitrile

Subas M. Sakya; Xinjun Hou; Martha L. Minich; Bryson Rast; Andrei Shavnya; Kristin Lundy DeMello; Hengmiao Cheng; Jin Li; Burton H. Jaynes; Donald W. Mann; Carol F. Petras; Scott B. Seibel; Michelle L. Haven

Bioorganic & Medicinal Chemistry Letters | 2006

5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers

Subas M. Sakya; Hengmiao Cheng; Kristin Lundy DeMello; Andrei Shavnya; Martha L. Minich; Bryson Rast; Jason K. Dutra; Chao Li; Robert J. Rafka; David A. Koss; Jin Li; Burton H. Jaynes; Carl Bernard Ziegler; Donald W. Mann; Carol F. Petras; Scott B. Seibel; Annette M. Silvia; David M. George; Anne Hickman; Michelle L. Haven; Michael P. Lynch

Tetrahedron Letters | 2005

Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles

Andrei Shavnya; Subas M. Sakya; Martha L. Minich; Bryson Rast; Kristin Lundy DeMello; Burton H. Jaynes

Bioorganic & Medicinal Chemistry | 2005

In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor

Jin Li; Michael P. Lynch; Kristin Lundy DeMello; Subas M. Sakya; Hengmiao Cheng; Robert J. Rafka; Brian Scott Bronk; Burton H. Jaynes; Carolyn Rose Kilroy; Donald W. Mann; Michelle L. Haven; Nicole L. Kolosko; Carol F. Petras; Scott B. Seibel; Lisa A. Lund

Archive | 2003