Kristína Czekóová

Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson’s disease: an fMRI study

The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson’s disease. We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on outcome evaluation following card selection, because we expected this aspect of decision-making to be impaired in PD patients. The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g., the limbic fronto-striatal circuit of the basal ganglia) during decision-making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement after a loss in PD patients in the ON state in comparison to a healthy population.

Exploring the development of the mirror neuron system: finding the right paradigm.

Due to its ability to map an observed action onto the observers own cortical motor circuits, the mirror neuron system (MNS) has been implicated in many facets of social cognition. As such, achieving an understanding of the typical development of this intriguing brain system seems obvious. Only now, however, are studies attempting to explore the processes and principles behind the emergence of the MNS. This article critically reviews a number of experimental paradigms employed in this endeavor. We conclude by suggesting that future neuroscientific investigations should incorporate a response-stimulus procedure, whereby action execution results in, not from, novel sensory stimuli.

Copying You Copying Me: Interpersonal Motor Co- Ordination Influences Automatic Imitation

Moving in a co-ordinated fashion with another individual changes our behaviour towards them; we tend to like them more, find them more attractive, and are more willing to co-operate with them. It is generally assumed that this effect on behaviour results from alterations in representations of self and others. Specifically, through neurophysiological perception-action matching mechanisms, interpersonal motor co-ordination (IMC) is believed to forge a neural coupling between actor and observer, which serves to blur boundaries in conceptual self-other representations and causes positive views of the self to be projected onto others. An investigation into this potential neural mechanism is lacking, however. Moreover, the specific components of IMC that might influence this mechanism have not yet been specified. In the present study we exploited a robust behavioural phenomenon – automatic imitation – to assess the degree to which IMC influences neural action observation-execution matching mechanisms. This revealed that automatic imitation is reduced when the actions of another individual are perceived to be synchronised in time, but are spatially incongruent, with our own. We interpret our findings as evidence that IMC does indeed exert an effect on neural perception-action matching mechanisms, but this serves to promote better self-other distinction. Our findings demonstrate that further investigation is required to understand the complex relationship between neural perception-action coupling, conceptual self-other representations, and social behaviour.

It's all in the past: temporal-context effects modulate subjective evaluations of emotional visual stimuli, regardless of presentation sequence

The aim of this study was to investigate if and how temporal context influences subjective affective responses to emotional images. To do so, we examined whether the subjective evaluation of a target image is influenced by the valence of its preceding image, and/or its overall position in a sequence of images. Furthermore, we assessed if these potentially confounding contextual effects can be moderated by a common procedural control: randomized stimulus presentation. Four groups of participants evaluated the same set of 120 pictures from the International Affective System (IAPS) presented in four different sequences. Our data reveal strong effects of both aspects of temporal context in all presentation sequences, modified only slightly in their nature and magnitude. Furthermore, this was true for both valence and arousal ratings. Subjective ratings of negative target images were influenced by temporal context most strongly across all sequences. We also observed important gender differences: females expressed greater sensitivity to temporal-context effects and design manipulations relative to males, especially for negative images. Our results have important implications for future emotion research that employs normative picture stimuli, and contributes to our understanding of context effects in general.

Orthogonal-compatibility effects confound automatic imitation: implications for measuring self–other distinction

Accurate distinction between self and other representations is fundamental to a range of social cognitive capacities, and understanding individual differences in this ability is an important aim for psychological research. This demands accurate measures of self–other distinction (SOD). The present study examined an experimental paradigm employed frequently to measure SOD in the action domain; specifically, we evaluated the rotated finger-action stimuli used increasingly to measure automatic imitation (AI). To assess the suitability of these stimuli, we compared AI elicited by different action stimuli to the performance on a perspective-taking task believed to measure SOD in the perception domain. In two separate experiments we reveal three important findings: firstly, we demonstrate a strong confounding influence of orthogonal-compatibility effects on AI elicited by certain rotated stimuli. Second, we demonstrate the potential for this confounding influence to mask important relationships between AI and other measures of SOD; we observed a relationship between AI and perspective-taking performance only when the former was measured in isolation of orthogonality compatibility. Thirdly, we observed a relationship between these two performance measures only in a sub-group of individuals exhibiting a pure form of AI. Furthermore, this relationship revealed a self-bias in SOD—reduced AI was associated with increased egocentric misattributions in perspective taking. Together, our findings identify an important methodological consideration for measures of AI and extend previous research by showing an egocentric style of SOD across action and perception domains.

Social cognition and idiopathic isolated cervical dystonia

For a long time, cervical dystonia (CD) has been characterised only by disturbances in motor functioning. Despite accumulating evidence for symptomatology in various non-motor domains, to date no study has investigated social cognition in CD. The aim of this study was to compare performance of CD patients and healthy controls in neurocognitive and socio-cognitive domain. Twenty-five non-depressed patients with CD and 26 healthy controls underwent neuropsychological testing. This involved assessment of cognitive status (general intellect, verbal memory, and executive function), and socio-cognitive functions using a Theory of mind task and self-report on empathy and emotion regulation. In comparison to controls, CD patients displayed significantly decreased cognitive abilities, particularly in executive function and verbal memory tasks. Difficulties in inferring mental states on both cognitive and affective levels were also observed. The largest discrepancies were detected in understanding intentionality in others. Poorer performance in cognitive and socio-cognitive tasks was unrelated to severity of the disease. This is the first evidence of compromised socio-cognitive functions in CD patients, highlighting this domain as another facet of non-motor symptoms of this disease. Future studies should advance our understanding of the extent, nature, and time course of these deficits in other aspects of social cognition in this patient population.

Personality systems, spirituality, and existential well-being : a person-centered perspective

Recent research on the salutogenic benefits of spirituality and religiosity has yielded inconsistent findings. It is suggested that such discrepancies reflect individual differences in personality, but this cannot be investigated with variable-driven approaches. The present study measured the influence of personality on the relationship between spirituality and existential well-being (EWB) from the perspective of Personality Systems Interaction theory—an approach focused on functional relationships between cognitive and affective systems, using Latent Profile Analysis. Three major results emerged: First, we identified discrete Analytical, Intuitive, and Flexible personality profiles resembling closely the prototypes reported elsewhere. Second, while preferences for intuitive cognitive processing resulted in high scores on all dimensions of spirituality and EWB, the reverse was true for individuals prone to analytical information processing, replicating previous research. Third, EWB operates independently from other spirituality dimensions, and relates differentially to distinct personality profiles.

A dual-fMRI investigation of the iterated Ultimatum Game reveals that reciprocal behaviour is associated with neural alignment

Dyadic interactions often involve a dynamic process of mutual reciprocity; to steer a series of exchanges towards a desired outcome, both interactants must adapt their own behaviour according to that of their interaction partner. Understanding the brain processes behind such bidirectional reciprocity is therefore central to social neuroscience, but this requires measurement of both individuals’ brains during real-world exchanges. We achieved this by performing functional magnetic resonance imaging (fMRI) on pairs of male individuals simultaneously while they interacted in a modified iterated Ultimatum Game (iUG). In this modification, both players could express their intent and maximise their own monetary gain by reciprocating their partner’s behaviour – they could promote generosity through cooperation and/or discourage unfair play with retaliation. By developing a novel model of reciprocity adapted from behavioural economics, we then show that each player’s choices can be predicted accurately by estimating expected utility (EU) not only in terms of immediate payoff, but also as a reaction to their opponent’s prior behaviour. Finally, for the first time we reveal that brain signals implicated in social decision making are modulated by these estimates of EU, and become correlated more strongly between interacting players who reciprocate one another.

Neurobehavioural evaluation of rehabilitation programs for dangerous drivers

Study aim to advance understanding of empathy in different driver samples, and to identify ways of modifying such social behaviour in dangerous drivers. This is achieved by evaluating empathy – related driver – rehabilitation programs with a novel neurobehavioral technique. Statistics show that almost 85% of road – traffic accidents in the Czech Republic are caused by the drivers themselves, and approximately 63% of these accidents are due to dangerous driving behaviour (e. g. Speeding, aggressive driving). Developing an effective rehabilitation requires an objective method of evaluation. Our rehabilitation program for dangerous drivers consists of empathy induction. Many studies have revealed associations between reduced empathic awareness and various forms of antisocial behavior. Further research also shows that empathic skills can be enhanced during group therapy. Empathy and anti – social behaviour are associated with specific patterns of brain function and structure. Present study focuses on way, how to evaluate the drivers ‘rehabilitation program. We used for this evaluation MRI data combining functional (e.g. partial least squares) and effective connectivity analyses (e.g. dynamic causal modelling) with measures of structural covariance. Combining these multidimensional network level analyses of neuroimaging data with measures of trait empathy and behavioral performance on socio – emotional tasks allow us better comprehensive into brain relationships.

What's the meaning of this? A behavioral and neurophysiological investigation into the principles behind the classification of visual emotional stimuli.

Two experiments were performed to investigate the principles by which emotional stimuli are classified on the dimensions of valence and arousal. In Experiment 1, a large sample of healthy participants rated emotional stimuli according to both broad dimensions. Hierarchical cluster analyses performed on these ratings revealed that stimuli were clustered according to their semantic content at the beginning of the agglomerative process. Example semantic themes include food, violence, nudes, death, and objects. Importantly, this pattern occurred in a parallel fashion for ratings on both dimensions. In Experiment 2, we investigated if the same semantic clusters were differentiated at the neurophysiological level. Intracerebral EEG was recorded from 18 patients with intractable epilepsy who viewed the same set of stimuli. Not only did electrocortical responses differentiate between these data-defined semantic clusters, they converged with the behavioral measurements to highlight the importance of categories associated with survival and reproduction. These findings provide strong evidence that the semantic content of affective material influences their classification along the broad dimensions of valence and arousal, and this principle of categorization exerts an effect on the evoked emotional response. Future studies should consider data-driven techniques rather than normative ratings to identify more specific, semantically related emotional images.