Kristofer Olofsson

Microwave methods in organic synthesis

P. Appukkuttan and E. Van der Eycken: Microwave-Assisted Natural Product Chemistry.- E. Suna, I. Mutule: Microwave-Assisted Heterocyclic Chemistry.- P. Nilsson, K. Olofsson, M. Larhed: Microwave-Assisted and Metal-Catalyzed Coupling Reactions.- W. Zhang: Microwave-Enhanced High-Speed Fluorous Synthesis.- J. Wannberg, K. Ersmark, M. Larhed: Microwave-Accelerated Synthesis of Protease Inhibitors.- C.R. Strauss and R.S. Varma: Microwaves in Green and Sustainable Chemistry.- J.M. Kremsner, A. Stadler, C.O. Kappe: The Scale-Up of Microwave-Assisted Organic Synthesis

Catalytic direct acetoxylation of indoles.

3-Acetoxyindole-2-carboxylates could be readily synthesized in a Pd(OAc)(2)- or PtCl(2)-catalyzed direct C-3 acetoxylation of indole-2-carboxylates using PhI(OAc)(2) as a terminal oxidant.

N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase.

High-throughput screening was used to find selective inhibitors of human 15-lipoxygenase-1 (15-LOX-1). One hit, a 1-benzoyl substituted pyrazole-3-carboxanilide (1a), was used as a starting point in a program to develop potent and selective 15-LOX-1 inhibitors.