Krystyna Skupinska | Researchain

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Featured researches published by Krystyna Skupinska.

Bioorganic & Medicinal Chemistry Letters | 2011

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication

Renato Skerlj; Gary J. Bridger; Ernie Mceachern; Curtis Harwig; Christopher Ronald Smith; Trevor Wilson; Duane Veale; Helen Yee; Jason Crawford; Krystyna Skupinska; Rossana Wauthy; Wen Yang; Yongbao Zhu; David Bogucki; Maria Rosaria Di. Fluri; Jonathon Langille; Dana Huskens; Erik De Clercq; Dominique Schols

An early lead from the AMD070 program was optimized and a structure-activity relationship was developed for a novel series of heterocyclic containing compounds. Potent CXCR4 antagonists were identified based on anti-HIV-1 activity and Ca(2+) flux inhibition that displayed good pharmacokinetics in rat and dog.

Bioorganic & Medicinal Chemistry Letters | 2011

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

Renato Skerlj; Gary J. Bridger; Ernest J. McEachern; Curtis Harwig; Christopher Ronald Smith; Alan Kaller; Duane Veale; Helen Yee; Krystyna Skupinska; Rossana Wauthy; Letian Wang; Ian R. Baird; Yongbao Zhu; Kate Burrage; Wen Yang; Michael Sartori; Dana Huskens; Erik De Clercq; Dominique Schols

A novel series of CXCR4 antagonists were identified based on the substantial redesign of AMD070. These compounds possessed potent anti-HIV-1 activity and showed excellent pharmacokinetics in rat and dog.

Journal of Organic Chemistry | 2003

Enzymatic resolution of bicyclic 1-heteroarylamines using Candida antarctica lipase B.

Krystyna Skupinska; Ernest J. McEachern; Ian R. Baird; Renato T. Skerlj; Gary J. Bridger

Archive | 2004

CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS

Gary Bridger; Ernest J. Mceachern; Renato Skerlj; Dominique Schols; Ian R. Baird; Alan Kaller; Curtis Harwig; Yongbao Zhu; Gang Chen; Krystyna Skupinska

Journal of Organic Chemistry | 2002

Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines

Krystyna Skupinska; Ernest J. McEachern; Renato T. Skerlj; Gary J. Bridger

Archive | 2002

Synthesis of enantiomerically pure amino-substituted fused bicyclic rings

Ernest J. McEachern; Gary J. Bridger; Krystyna Skupinska; Renato T. Skerlj

Heterocycles | 2006

Facile Preparation of Substituted Benz- imidazole-2-carboxylates

Ernest J. McEachern; Yongbao Zhu; Krystyna Skupinska

Archive | 2004

Composes de liaison aux recepteurs de chimiokine cxcr4

Gary J. Bridger; Ernest J. McEachern; Renato T. Skerlj; Dominique Schols; Ian R. Baird; Al Kaller; Curtis Harwig; Yongbao Zhu; Gang Chen; Krystyna Skupinska

Archive | 2004

Composes heterocycliques se liant aux recepteurs des chimiokines et qui presentent une efficacite accrue

Gary J. Bridger; Ernest J. McEachern; Renato T. Skerlj; Dominique Schols; Krystyna Skupinska; Gang Chen; Yongbao Zhu; Curtis Harwig; Al Kaller; Ian R. Baird; Markus Metz

Archive | 2004

Cxcr4-chemokinrezeptor-bindende verbindungen

Gary J. Bridger; Ernest J. McEachern; Renato T. Skerlj; Dominique Schols; Ian R. Baird; Al Kaller; Curtis Harwig; Yongbao Zhu; Gang Chen; Krystyna Skupinska

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