Kumar Balashanmuga Pabbisetty
Bristol-Myers Squibb
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Publication
Featured researches published by Kumar Balashanmuga Pabbisetty.
Bioorganic & Medicinal Chemistry Letters | 2016
Leon M Smith; Michael J. Orwat; Zilun Hu; Wei Han; Cailan Wang; Karen A. Rossi; Paul J. Gilligan; Kumar Balashanmuga Pabbisetty; Honey Osuna; James R. Corte; Alan R. Rendina; Joseph M. Luettgen; Pancras C. Wong; Ranga Narayanan; Timothy W. Harper; Jeffrey M. Bozarth; Earl J. Crain; Anzhi Wei; Vidhyashankar Ramamurthy; Paul E. Morin; Baomin Xin; Joanna Zheng; Dietmar Seiffert; Mimi L. Quan; Patrick Y.S. Lam; Ruth R. Wexler; Donald J. P. Pinto
The synthesis, structural activity relationships (SAR), and selectivity profile of a potent series of phenylalanine diamide FXIa inhibitors will be discussed. Exploration of P1 prime and P2 prime groups led to the discovery of compounds with high FXIa affinity, good potency in our clotting assay (aPPT), and high selectivity against a panel of relevant serine proteases as exemplified by compound 21. Compound 21 demonstrated good in vivo efficacy (EC50=2.8μM) in the rabbit electrically induced carotid arterial thrombosis model (ECAT).
ACS Medicinal Chemistry Letters | 2015
Zilun Hu; Pancras C. Wong; Paul J. Gilligan; Wei Han; Kumar Balashanmuga Pabbisetty; Jeffrey M. Bozarth; Earl J. Crain; Timothy W. Harper; Joseph M. Luettgen; Joseph E. Myers; Vidhyashankar Ramamurthy; Karen A. Rossi; Steven Sheriff; Carol A. Watson; Anzi Wei; Joanna J. Zheng; Dietmar A. Seiffert; Ruth R. Wexler; Mimi L. Quan
Archive | 2015
James R. Corte; Lucca Indawati De; Tianan Fang; Wu Yang; Yufeng Wang; Andrew K. Dilger; Kumar Balashanmuga Pabbisetty; William R. Ewing; Yeheng Zhu; Ruth R. Wexler; Donald J. P. Pinto; Michael J. Orwat; Leon M Smith
Archive | 2015
Andrew K. Dilger; James R. Corte; Lucca Indawati De; Tianan Fang; Wu Yang; Yufeng Wang; Kumar Balashanmuga Pabbisetty; William R. Ewing; Yeheng Zhu; Ruth R. Wexler; Donald J. P. Pinto; Michael J. Orwat; Ii Leon M. Smith
Archive | 2015
James R. Corte; Indawati De Lucca; Tianan Fang; Wu Yang; Yufeng Wang; Andrew K. Dilger; Kumar Balashanmuga Pabbisetty; William R. Ewing; Yeheng Zhu; Ruth R. Wexler; Donald J. P. Pinto; Michael J. Orwat; Leon M Smith
Archive | 2016
Andrew K. Dilger; James R. Corte; Indawati De Lucca; Tianan Fang; Wu Yang; Yufeng Wang; Kumar Balashanmuga Pabbisetty; William R. Ewing; Yeheng Zhu; Ruth R. Wexler; Donald J. P. Pinto; Michael J. Orwat; M. Smith Ii Leon
Archive | 2016
Nicholas R. Wurtz; Andrew Quoc Viet; Scott A. Shaw; Benjamin P. Vokits; Ellen K. Kick; Meriah Neissel Valente; Andrew K. Dilger; Kumar Balashanmuga Pabbisetty; Sutjano Jusuf
Archive | 2017
Wu Yang; James R. Corte; Paul J. Gilligan; Donald J. P. Pinto; William R. Ewing; Andrew K. Dilger; Yufeng Wang; Tianan Fang; Kumar Balashanmuga Pabbisetty; Ii Leon M. Smith
Archive | 2017
Andrew K. Dilger; Donald J. P. Pinto; James R. Corte; Kumar Balashanmuga Pabbisetty; Leon M Smith; Paul J. Gilligan; Tianan Fang; William R. Ewing; Wu Yang; Yufeng Wang
Archive | 2017
Ii Leon M. Smith; Vladimir Ladziata; Indawati Delucca; Donald J. P. Pinto; Michael J. Orwat; Andrew K. Dilger; Kumar Balashanmuga Pabbisetty; Wu Yang; Scott A. Shaw; Peter W. Glunz; Manoranjan Panda
