Kung-Hsuan Lin

Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

Ultrafast carrier dynamics in ZnO nanorods

Free exciton and above-band-gap free carrier dynamics in ZnO nanorods have been investigated at room temperature with a femtosecond transient transmission measurement. Following the photoexcitation of above-band-gap free carriers, an extremely fast external thermalization time on the order of 200 fs can be observed. Under high excitation, hot phonon effects were found to delay the carrier cooling process. While the photoexcitation energy was tuned to match the free exciton transition, stable exciton formation can be uncovered while no evident exciton ionization process can be found unless the photoexcited exciton density exceeded the Mott density.

Spatial manipulation of nanoacoustic waves with nanoscale spot sizes

Coherent acoustic phonons are generated at terahertz frequencies when semiconductor quantum-well nanostructures are illuminated by femtosecond laser pulses. These phonons-also known as nanoacoustic waves-typically have wavelengths of tens of nanometres, which could prove useful in applications such as non-invasive ultrasonic imaging and sound amplification by the stimulated emission of radiation. However, optical diffraction effects mean that the nanoacoustic waves are produced with spot sizes on the micrometre scale. Near-field optical techniques can produce waves with smaller spot sizes, but they only work near surfaces. Here, we show that a far-field optical technique--which suffers no such restrictions--can be used to spatially manipulate the phonon generation process so that nanoacoustic waves are emitted with lateral dimensions that are much smaller than the laser wavelength. We demonstrate that nanoacoustic waves with wavelengths and spot sizes of the order of 10 nm and 100 nm, respectively, can be generated and detected.

Transmission of light through quantum heterostructures modulated by coherent acoustic phonons

We investigate the optical transmission oscillation of multiple quantum wells (MQWs) under the modulation of coherent acoustic phonons. We treat the coherent acoustic phonons as a semiclassical wave obeying continuum elastic equations. Starting from the microscopic electron–phonon interaction Hamiltonian, we obtain expressions for optical absorption modulation of the MQWs due to coherent acoustic phonons. The acoustic phonons introduce a renormalization to single-particle energy and furthermore modify the resonant condition of photon absorption. The optical transmission modulation can be conveniently expressed with the use of sensitivity functions. We derive the analytical expressions for the sensitivity functions by which we calculate the optical transient transmission changes. The calculated results are in good agreement with the experimental observations.

Generation of multicycle terahertz phonon-polariton waves in a planar waveguide by tilted optical pulse fronts

We demonstrate generation of frequency-tunable, multicycle terahertz phonon-polariton waves in a LiNbO3 slab waveguide. Because the waveguide modes show considerable phase-velocity dispersion, we are able to enhance frequency-selected narrowband terahertz waves by using femtosecond optical pulses whose intensity fronts are tilted at angles that meet the appropriate noncollinear phase-matching conditions. The pump light is spread across a large area of the crystalline waveguide within which coherent terahertz wave generation occurs, averting material damage, while yielding peak-to-peak terahertz field amplitudes in the waveguide of 50 kV/cm.

Two-dimensional nanoultrasonic imaging by using acoustic nanowaves

Two-dimensional ultrasonic imaging is demonstrated by using acoustic nanowaves. With a 14nm acoustic wavelength, both axial and transverse resolutions of a few tens of nanometers are thus achieved. This ultrasonic-based nondestructive technique not only images but also reconstructs the subsurface nanostructures including the depth positions of the buried interfaces. By demonstrating two-dimensional nanoultrasonic scans in depth and transverse (or z-x) axes, we show that acoustic nanowaves can be a promising tool for future subsurface three-dimensional noninvasive imaging with nanometer resolutions.

Optical piezoelectric transducer for nano-ultrasonics

Piezoelectric semiconductor strained layers can be treated as piezoelectric transducers to generate nanometer-wavelength and THz-frequency acoustic waves. The mechanism of nano-acoustic wave (NAW) generation in strained piezoelectric layers, induced by femtosecond optical pulses, can be modeled by a macroscopic elastic continuum theory. The optical absorption change of the strained layers modulated by NAW through quantum-confined Franz-Keldysh (QCFK) effects allows optical detection of the propagating NAW. Based on these piezoelectric-based optical principles, we have designed an optical piezoelectric transducer (OPT) to generate NAW. The optically generated NAW is then applied to one-dimensional (1-D) ultrasonic scan for thickness measurement, which is the first step toward multidimensional nano-ultrasonic imaging. By launching a NAW pulse and resolving the returned acoustic echo signal with femtosecond optical pulses, the thickness of the studied layer can be measured with <1 nm resolution. This nano-structured OPT technique will provide the key toward the realization of nano-ultrasonics, which is analogous to the typical ultrasonic techniques but in a nanometer scale.

Biomolecular imaging based on far-red fluorescent protein with a high two-photon excitation action cross section

Received October 14, 2005; revised January 7, 2006; accepted January 9, 2006; posted January 12, 2006 (Doc. ID 65391) The two-photon excitation action cross section of Hc-Red fluorescent proteins (Hc-RFPs) is measured and found to be of the same order as that of enhanced green fluorescent proteins. With a 618 nm emission wavelength in the far-red region and with an excitation wavelength around 1200 nm, Hc-RPF-based two-photon fluorescence microscopy (2PFM) can offer deep penetration capability inside live samples and is ideal for in vivo gene expression study and biomolecular imaging in live objects. In vivo 2PFM of the developing heart deep inside a transgenic zebrafish embryo tagged by Hc-RFP is also successfully demonstrated.

Generation of picosecond acoustic pulses using a p‐n junction with piezoelectric effects

We demonstrate the generation of picosecond acoustic pulses using a piezoelectric-semiconductor-based p‐n junction structure. This p‐n junction picosecond ultrasonic experiment confirms that the piezoelectric effect dominates the thermal expansion and deformation-potential coupling in the generation of picosecond acoustic pulses. The characteristics of the p‐n initiated acoustic pulses are determined by the width and the field strength inside the depletion region. Our study indicates the future possibility to electrically control the acoustic pulse characteristics if we could apply an external bias to modulate the depletion region width.

Comparison of phase-sensitive imaging techniques for studying terahertz waves in structured LiNbO 3

Four phase-sensitive imaging methods (Talbot, phase contrast, Sagnac, and polarization gating) used for detecting terahertz-frequency waves in structured lithium niobate slabs are compared analytically and experimentally. It is demonstrated that both phase contrast and a self-compensating polarization gating geometry can generate in-focus images of the sample and quantitatively measure the terahertz electric field. Of these two methods polarization gating has better signal-to-noise ratio and so is preferred for most situations, while phase contrast imaging has better spatial resolution and so is preferred for measurements involving fine structures or near-field effects.