Kunihiko Ozaki

Synthesis of taxoids 4. Novel and versatile methods for preparation of new taxoids by employing cis- or trans-phenyl glycidic acid

Abstract A novel route to the synthesis of docetaxel using esterification of (2R,3R)- or (2R, 3S)-glycidic acid with 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III is described. Related novel taxoids which have new side chains were synthesized from these synthetic intermediates.

SYNTHESIS OF TAXOIDS 3. A NOVEL AND EFFICIENT METHOD FOR PREPARATION OF TAXOIDS BY EMPLOYING CIS-GLYCIDIC ACID

Abstract A novel route for the synthesis of docetaxel ( 2 ) using esterification of (2 R , 3 R )-glycidic acid with 7,10-bis- O -(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III is described. Subsequent stereo- and regio-selective conversion afforded 2 and related novel compounds.