Kunio Ida

Effects of physical exercise prescribed by a medical support team on elderly lower extremity osteoarthritis combined with metabolic syndrome and/or type 2 diabetes

Aim:  The aims of the present study were to investigate the effectiveness of exercise intervention provided by a medical support team specializing in lifestyle‐related diseases in the treatment of elderly lower extremity osteoarthritis and to examine the influence of bodyweight decrease on changes in the evaluation indexes.

The evaluation of intertrochanteric osteotomy in relation to osteotomized angle and leg-length discrepancy for osteoarthritis of the hip.

A series of 103 joints in 93 patients with secondary osteoarthritis were treated by intertrochanteric osteotomy, and investigated on a nationwide basis. The types of osteotomy were classified as varus, 35 joints (62.5%); valgus, 22 joints (55%). The total number of cases with a combined error of 5 degrees was 48 with varus (85.7%) and 31 with valgus (77.5%) corrections. This indicates that a slight deficiency or excess of angulation does not significantly influence the clinical results. Cases with increased center-edge angle after varus osteotomy or with decreased AHI after valgus osteotomy demonstrated a relatively high rating of clinical improvement. Postoperative discrepancies of the leg length were more serious after varus osteotomy (with angulation of 25 degrees or more) than valgus osteotomies. The clinical results after either type, graded by the method of Tanaka were generally satisfactory.

Arthrodiatasis for chondrolysis with hinge abduction: a case report.

&NA; A 13‐year‐old boy with bilateral chronic slipped capital femoral epiphysis was referred to the Nagoya University Hospital. Chondrolysis occurred on the left side 3 months after a subcapital wedge osteotomy and a concavity of the femoral head appeared, which formed hinge abduction. Increase of the joint space and resolution of the hinge were achieved by arthrodiatasis. As arthrodiatasis can resolve hinge abduction by distraction and reduce mechanical stress, it may be taken into consideration as an option for diseases with hinge abduction.

Intertrochanteric osteotomy and total hip replacement for bilateral osteoarthritis of the hip: consideration of the nonoperated-on hip.

In early stages of osteoarthritis, osteotomy produced a satisfactory result with no adverse effects and significant improvement in the nonoperated-on contralateral hip. In many cases of unilateral osteotomy in a group with preoperative radiologic scores above 70, the function was either improved or unchanged in the nonoperated-on hip. In many cases with scores below 70, there was deterioration of joint structure. Bilateral osteotomy is recommended only in the cases with preoperative radiologic scores below 70. Osteotomy was prescribed on the contralateral hip within a short period of time after aarthroplasty. Deterioration occurred in some contralateral nonoperated-on hips when the preoperative clinical scores were high, while improvement generally occurred when preoperative scores were low.

Argyrophilic dark neurons appear diffusely in the brain after over hours treadmill running and swimming in the rat

Acute systemic administration of 3-nitropropionic acid (3-NPA, a mitochondrial toxin) produces striatum specific lesions and motor symptoms similar to those in Huntington’s disease. In the present study, we developed subacutely intoxicated animal models and tried to restore damaged neuronal circuit by neulal transpIantation. One month after repeated intoxication with 3NPA (10 mgikg, i.p. 10 injections over 20 days), the body weight of the animals decreased to 90 % of control’s, passive avoidance task was disturbed but there was no disturbance in rotorod walking. Two months after intoxication, there was a slight loss of neurons and glias in the lateral striatum but both behaviors were almost normalized. Striatal cell suspension derived from El6 fetal rats was transplanted into bilateral striatum of intoxicated animals at one month after intoxication. Neurons and glias survived well in the host striatum and good vascularization to the graft was detected at least two months after transplantation. Data suggest that fetal striatal graft to 3-NPA lesioned striatum may enhance neuronal reconstruction.