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Dive into the research topics where Kunio Takanohashi is active.

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Featured researches published by Kunio Takanohashi.


Heterocycles | 1993

Synthesis of a key intermediate for D-biotin via 1,3-cycloaddition of a thiocarbonyl ylide and sila-Pummerer rearrangement

Toru Yamano; Mitsutaka Tanaka; Kunio Takanohashi

An efficient preparation of a d-biotin intermediate, (±)-(3aα,4α,6aα)-1,3-dibenzyl-3a,4,6,6a-tetrahydro-4-hydroxy-1H-thieno[3,4-d]imidazol-2(3H)-one was accomplished by use of 1,3-cycloaddition of a thiocarbonyl ylide, Curtius rearrangement and sila-Pummerer rearrangement. Addition of p-toluenesulfonic acid was found to be effective to promote sila-Pummerer rearrangement of sterically unfavorable anti-2-trimethylsilyl sulfoxide


Journal of Organic Chemistry | 1969

Phosphorylation. IV. Selective phosphorylation of the primary hydroxyl group in nucleosides

Kinichi Imai; Shoichiro Fujii; Kunio Takanohashi; Yoshiyasu Furukawa; Toru Masuda; Mikio Honjo


The Journal of Antibiotics | 1987

ORALLY ACTIVE 1-(CYCLOHEXYLOXYCARBONYLOXY)ALKYL ESTER PRODRUGS OF CEFOTIAM

Tatsuo Nishimura; Yoshinobu Yoshimura; Akio Miyake; Masayoshi Yamaoka; Kunio Takanohashi; Naoru Hamaguchi; Shin-Ichiro Hirai; Takatsuka Yashiki; Mitsuo Numata


Archive | 1994

Process for producing vitamin A derivatives

Mitsutaka Tanaka; Tadashi Hanaoka; Kunio Takanohashi


Archive | 1993

Production of L-ascorbic acid

Kunio Takanohashi; Mitsutaka Tanaka; Toru Yamano


Chemistry Letters | 1993

Optical resolution of a d-biotin chiral intermediate by use of lipoprotein lipase

Shinji Tokuyama; Toru Yamano; Isao Aoki; Kunio Takanohashi; Kazuo Nakahama


Archive | 1992

Intermediates for d-biotin synthesis and their production

Toru Yamano; Kazuo Nakahama; Kunio Takanohashi


Journal of Nutritional Science and Vitaminology | 1993

Direct Optical Resolution of (.+-.)-Biotin and (.+-.)-Epibiotin by a Reversed-Phase High-Performance Liquid Chromatography.

Toru Yamano; Isao Aoki; Kunio Takanohashi


Bulletin of the Chemical Society of Japan | 1993

Synthesis of d-Biotin Chiral Intermediates via a Biochemical Method

Toru Yamano; Shinji Tokuyama; Isao Aoki; Yumiko Nishiguchi; Kazuo Nakahama; Kunio Takanohashi


Archive | 1980

Crystallized cephalosporin salts

Yoshinobu Yoshimura; Nobuhide Morikawa; Kunio Takanohashi

Collaboration


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Toru Yamano

Takeda Pharmaceutical Company

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Mitsutaka Tanaka

Takeda Pharmaceutical Company

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Shoichiro Fujii

Takeda Pharmaceutical Company

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Yoshinobu Yoshimura

Takeda Pharmaceutical Company

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Mitsuo Numata

Takeda Pharmaceutical Company

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Nobuhide Morikawa

Takeda Pharmaceutical Company

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Isao Aoki

Takeda Pharmaceutical Company

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Kazuo Nakahama

Takeda Pharmaceutical Company

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Tomoyuki Fujii

Takeda Pharmaceutical Company

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Shinji Tokuyama

Takeda Pharmaceutical Company

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