Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Kuo-You Huang is active.

Publication


Featured researches published by Kuo-You Huang.


Medicine | 2016

Association of Tic Disorders and Enterovirus Infection: A Nationwide Population-Based Study

Ching-Shu Tsai; Yao-Hsu Yang; Kuo-You Huang; Yena Lee; Roger S. McIntyre; Vincent Chin-Hung Chen

AbstractThere has been growing interest in the association between infectious disease and mental disorders, but an association between enterovirus (EV) infection and tic disorders has not been sufficiently explored. Herein, we aim to investigate the association between EV infection and incidence of tic disorders in a nationwide population-based sample using Taiwans National Health Insurance Research Database.We identified individuals aged ⩽18 years prior to 2005 with an inpatient diagnosis of EV infection and/or history of EV infection. Tic disorder was operationalized using International Classification of Disease, Revision 9, Clinical Modification (ICD-9-CM) codes 307.20–307.23.A total of 47,998 individuals with history of EV infection were compared to 47,998 sex-, age-, and urbanization-matched controls on incidence of tic disorders. The mean ± standard deviation follow-up period for all subjects was 9.7 ± 3.6 years; the mean latency period between initial EV infection and incident diagnosis of tic disorder diagnosis was 5.4 ± 2.8 years. EV infection was significantly associated with greater incidence of tic disorders (hazard ratio [HR] = 1.24, 95% CI: 1.07–1.45). When subgrouped on the basis of central nervous system (CNS) involvement, EV infection with CNS involvement was not significantly associated with greater incidence of tic disorders when compared to controls (HR = 1.25, 95% CI: 0.64–2.43); EV infection without CNS involvement was significantly associated greater incidence of tic disorders when compared to controls (HR = 1.24, 95% CI: 1.07–1.45). In addition, hospitalization for an EV infection did not increase the hazard for greater incidence of tic disorders (HR = 1.32, 95% CI: 1.04–1.67 with hospitalization and 1.22, 95% CI: 1.04–1.44 without hospitalization).EV infection is temporally associated with incidence of tic disorders. Our observations add to the growing body of literature implicating immune-inflammatory system in the pathoetiology of brain disorders in a subpopulation of individuals and serve as a clarion call for surveillance of symptoms suggestive of tic disorders in individuals with history of EV infection.


American Journal on Addictions | 2017

Depression and severity of substance dependence among heroin dependent patients with ADHD symptoms

Yin-To Liao; Chi-Yen Chen; Mei-Hing Ng; Kuo-You Huang; Wen-Chuan Shao; Tsang-Yaw Lin; Vincent Chin-Hung Chen; Michael Gossop

BACKGROUND AND OBJECTIVES Comorbid attention deficit hyperactivity disorder (ADHD) symptoms are highly prevalent among heroin-dependent patients. We aim to investigate differences in dependence severity, depression, and quality of life between heroin-dependent patients with and without ADHD-screened positive. METHODS Heroin-dependent participants (n = 447) entering methadone maintenance treatment were divided into ADHD-screened positive (ADHD-P) and ADHD-screened negative (ADHD-N) groups according to scores of Adult ADHD Self-Report Scale (ASRS). Mini-International Neuropsychiatric Interview was used to identify current and lifetime depressive episodes and suicidality. Substance use disorder, depression, family support, and quality of life in two groups were also assessed. RESULTS About 7.8% (n = 35) scored 24 or higher of ASRS indicating highly likely Adult ADHD. More heroin-dependent patients of ADHD-P had a current depressive episode (p = .02). They had higher Center for Epidemiological Studies Depression (CESD) scores (p = .003), and more severe heroin dependence (p = .006). Poorer family support and quality of life in physical, and psychological domains were found in patients of ADHD-P compared to ADHD-N. DISCUSSION AND CONCLUSIONS Heroin-dependent patients of ADHD-P represent a vulnerable minority. They were comorbid with regard to depression, greater substance dependence severity, and poorer quality of life. SCIENTIFIC SIGNIFICANCE Assessment for ADHD symptoms in heroin-dependent patients may be indicated for the effective management of the complex problems of these patients. (Am J Addict 2017;26:26-33).


Medicine | 2016

Endometrial cancer and antidepressants: A nationwide population-based study.

Chiao-Fan Lin; Hsiang-Lin Chan; Yi-Hsuan Hsieh; Hsin-Yi Liang; Wei-Che Chiu; Kuo-You Huang; Yena Lee; Roger S. McIntyre; Vincent Chin-Hung Chen

AbstractTo our knowledge, the association between antidepressant exposure and endometrial cancer has not been previously explored. Herein, we aim to investigate the association between antidepressant prescription, including novel antidepressants, and the risk for endometrial cancer in a population-based study.Data for the analysis were derived from National Health Insurance Research Database. We identified 8392 cases with a diagnosis of endometrial cancer and 82,432 matched controls. A conditional logistic regression model was used, with adjusting for potentially confounding variables (e.g., comorbid psychiatric diseases, comorbid physical diseases, and other medications). Risk for endometrial cancer in the population-based study sample was categorized by, and assessed as a function of, antidepressant prescription and cumulative dosage.We report no association between endometrial cancer incidence and antidepressant prescription, including those prescribed either selective serotonin reuptake inhibitors (adjusted odds ratio [OR] = 0.98; 95% confidence interval [CI], 0.84–1.15) or serotonin norepinephrine reuptake inhibitors (adjusted OR = 1.14; 95% CI, 0.76–1.71). We also did not identify an association between higher cumulative doses of antidepressant prescription and endometrial cancer.There was no association between antidepressant prescription and endometrial cancer.


Psycho-oncology | 2018

SSRIs Associated with Decreased Risk of Hepatocellular Carcinoma: A Population-based Case-control Study

Hsiang-Lin Chan; Wei-Che Chiu; Vincent Chin-Hung Chen; Kuo-You Huang; Tsu-Nai Wang; Yena Lee; Roger S. McIntyre; Tsai-Ching Hsu; Charles Tzu-Chi Lee; Bor-Show Tzang

Hepatocellular carcinoma (HCC) is the second leading cancer‐related cause of mortality worldwide. Antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), are commonly used worldwide. Available evidence investigating the association between SSRIs use and HCC risk is limited.


PLOS ONE | 2017

The association between methylphenidate treatment and the risk for fracture among young ADHD patients: A nationwide population-based study in Taiwan

Vincent Chin-Hung Chen; Yao-Hsu Yang; Yin-To Liao; Ting-Yu Kuo; Hsin-Yi Liang; Kuo-You Huang; Yin-Cheng Huang; Yena Lee; Roger S. McIntyre; Tzu-Chin Lin

[This corrects the article DOI: 10.1371/journal.pone.0173762.].


Oncotarget | 2017

Hepatocellular carcinoma and antidepressants: a nationwide population-based study.

Vincent C. Chen; Chiao-Fan Lin; Yi-Hsuan Hsieh; Hsin-Yi Liang; Kuo-You Huang; Wei-Che Chiu; Yena Lee; Roger S. McIntyre; Hsiang-Lin Chan

Hepatocellular carcinoma (HCC) is highly prevalent in Asia. Antidepressants have been associated with increase in hepatocellular carcinoma. This is the first Asian population-based study to evaluate the association between antidepressant use and risk of HCC. Based on Taiwans National Health Insurance Research Database, we conducted a nationwide population-based study. A total of 49,998 cases with HCC were identified and paired with 244,236 randomly selected controls. The data was analyzed via the conditional logistic regression model adjusting for several confounding factors. Use of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) was associated with lower risk for HCC. No apparent association was found between use of other classes of antidepressants and HCC, including monoamine oxidase inhibitors (MAOIs), serotonin norepinephrine reuptake inhibitors (SNRIs), trazodone, mirtazapine and bupropion. The findings of a protective effect of TCAs and SSRIs for HCC should be interpreted with caution and warrants further research.


The Journal of Clinical Psychiatry | 2017

Herpes Zoster and Dementia: A Nationwide Population-Based Cohort Study.

Vincent Chin-Hung Chen; Shu-I Wu; Kuo-You Huang; Yao-Hsu Yang; Ting-Yu Kuo; Hsin-Yi Liang; Kuan-Lun Huang; Michael Gossop

OBJECTIVE Some infectious diseases have been found to be associated with cognitive impairment and dementia. However, the relationship between herpes zoster and dementia has received little attention. This study aimed to investigate this association as well as associations of antiviral treatments for herpes zoster and incident dementia using a large national sample. METHODS Cases were identified from the Taiwan National Health Insurance Research Database with a new diagnosis of herpes zoster (ICD-9-CM code: 053) between 1997 and 2013. Each identified individual with a case of herpes zoster was compared with 1 sex-, age-, and residence-matched control subject. Both groups were followed until the first diagnosis of dementia (ICD-9-CM codes: 290.0 to 290.4, 294.1, 331.0 to 331.2, and 331.82), withdrawal from the registry, or the end of 2013. Cox regression analyses and competing risk model were applied, adjusting for sex, age, residence, depression, autoimmune disease, ischemic stroke, traumatic brain injury, alcohol use disorder, and antiviral treatments for herpes zoster to evaluate the risk of interest. RESULTS A total of 39,205 cases with herpes zoster were identified. Of the 78,410 study and comparison subjects, 4,204 were diagnosed as having dementia during a mean (SD) follow-up period of 6.22 (4.05) years. Herpes zoster was associated with a slightly increased risk of dementia in the fully adjusted model (hazard ratio [HR] = 1.11; 95% CI, 1.04-1.17). Prescriptions of antiviral therapy were associated with a reduced risk of developing dementia following the diagnosis of herpes zoster (HR = 0.55; 95% CI, 0.40-0.77). CONCLUSIONS Herpes zoster was associated with an increased risk of dementia, independent of potential confounding factors. Antiviral treatment might be protective in preventing dementia in patients with herpes zoster.


Medicine | 2015

Invasive Cervical Cancer and Antidepressants: A Nationwide Population-Based Study

Hsiang-Lin Chan; Yi-Hsuan Hsieh; Chiao-Fan Lin; Hsin-Yi Liang; Kuo-You Huang; Wei-Che Chiu; Yena Lee; Roger S. McIntyre; Vincent Chin-Hung Chen

Abstract To our knowledge, no prior population-based study has been published wherein the primary aim was to evaluate whether an association between psychotropic drug prescription and cervical cancer exists. Herein we have conducted the first study that primarily aimed to determine the association between antidepressants use and risk of invasive cervical cancer in the general population. This is a population-based study utilizing Taiwans National Health Insurance Research Database. We identified 26,262 cases with invasive cervical cancer and 129,490 controls. We adopted the conditional logistic regression model as the statistical method and adjusted for potential confounding factors. The prescription of selective serotonin reuptake inhibitors (SSRIs) (adjusted OR = 0.93, 95% CI = 0.84–1.04), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), serotonin norepinephrine reuptake inhibitors (SNRIs), mirtazapine and bupropion, adjusting for cumulative dose, was not associated with an increased, or decreased, risk for invasive cervical cancer. An association between trazodone prescription and invasive cervical cancer was observed (adjusted OR = 1.22, 95% CI = 1.03–1.43). An association between the major classes of antidepressants and invasive cervical cancer was not observed herein. Our preliminary finding regarding a possible association between trazodone and cervical cancer requires replication.


Journal of Affective Disorders | 2018

Risks of road injuries in patients with bipolar disorder and associations with drug treatments: A population-based matched cohort study

Vincent Chin-Hung Chen; Yao-Hsu Yang; Lee Ch; Jennifer Wong; Lynn E. Ponton; Yena Lee; Roger S. McIntyre; Kuo-You Huang; Shu-I Wu

OBJECTIVE Using a nation-wide, population-based dataset, we aimed to investigate the risk of road injury among individuals with bipolar disorder (BD) compared to individuals without BD. In addition, we investigated the putative moderating effects of prescription for lithium, anticonvulsants, antidepressants, and/or first- or second-generation antipsychotic agents on the association between BD and risk of road injury. METHOD As part of an16-year longitudinal cohort study, we compared the risk of road injuries among study subjects aged 16 and above with a diagnosis of BD, with ten age- and sex-matched sample of individuals without BD. Individuals were compared on measures of incidence on road injuries using medical claims data based on the ICD-9-CM codes: E800~807, E810~817, E819~830, E840~848. Time dependent Cox regression models were used to adjust for time-varying covariates such as age, and medication uses. Hazard ratios before and after adjusting for age, sex, other comorbidities, and drug use were calculated. RESULTS 3953 people with BD were matched with 39,530 controls from general population. Adjusted hazard ratios revealed a 1.66-fold (95% CI 1.40-1.97) increase in risk of road injuries among bipolar subjects when compared to controls. Female gender, older age (i.e. over 80), residence in areas of highest levels of urbanization, and use of antidepressants were associated with a lower risk of road injuries. CONCLUSIONS In this large, national, population-based cohort, BD was associated with an elevated risk of road injuries. However, prescriptions of antidepressants might help mitigate the foregoing risk.


European Child & Adolescent Psychiatry | 2018

Dosage of methylphenidate and traumatic brain injury in ADHD: a population-based study in Taiwan

Yin-To Liao; Yao-Hsu Yang; Ting-Yu Kuo; Hsin-Yi Liang; Kuo-You Huang; Tsu-Nai Wang; Yena Lee; Roger S. McIntyre; Vincent Chin-Hung Chen

Collaboration


Dive into the Kuo-You Huang's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Yena Lee

University Health Network

View shared research outputs
Top Co-Authors

Avatar

Hsin-Yi Liang

Memorial Hospital of South Bend

View shared research outputs
Top Co-Authors

Avatar

Yao-Hsu Yang

Memorial Hospital of South Bend

View shared research outputs
Top Co-Authors

Avatar

Wei-Che Chiu

Fu Jen Catholic University

View shared research outputs
Top Co-Authors

Avatar

Hsiang-Lin Chan

Memorial Hospital of South Bend

View shared research outputs
Top Co-Authors

Avatar

Ting-Yu Kuo

Memorial Hospital of South Bend

View shared research outputs
Top Co-Authors

Avatar

Chiao-Fan Lin

Memorial Hospital of South Bend

View shared research outputs
Top Co-Authors

Avatar

Yi-Hsuan Hsieh

Memorial Hospital of South Bend

View shared research outputs
Researchain Logo
Decentralizing Knowledge