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Kwang-Hwan Jhee

National Institutes of Health

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Featured researches published by Kwang-Hwan Jhee.

Archive | 2000

Structure and Function of Tryptophan Synthase

Edith Wilson Miles; Ying-Xin Fan; Kwang-Hwan Jhee; Hyeon-Su Ro; Peter McPhie; Sangkee Rhee; David R. Davies

Crystal structures of the tryptophan synthase α2β2complex show binding sites in the β subunit for pyridoxal phosphate, for substrates, and for a monovalent cation. Cations, including guanidine at low concentration, activate tryptophan synthase. Molecular modeling indicates that guanidine could bind to the cation site in the β subunit. Our results demonstrate that the conformational states of the tryptophan synthase α2β2 complex are regulated by monovalentcations, chaotropic agents, pH, α subunit ligands, and temperature.

Journal of Biological Chemistry | 2004

Production of the Neuromodulator H2S by Cystathionine β-Synthase via the Condensation of Cysteine and Homocysteine

Xulin Chen; Kwang-Hwan Jhee; Warren D. Kruger

Antioxidants & Redox Signaling | 2005

The Role of Cystathionine β-Synthase in Homocysteine Metabolism

Kwang-Hwan Jhee; Warren D. Kruger

Biochemistry | 2000

Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation.

Kwang-Hwan Jhee; Peter McPhie; Edith Wilson Miles

Journal of Biological Chemistry | 2000

Yeast Cystathionine β-Synthase Is a Pyridoxal Phosphate Enzyme but, Unlike the Human Enzyme, Is Not a Heme Protein

Kwang-Hwan Jhee; Peter McPhie; Edith Wilson Miles

Journal of Biochemistry | 2000

Three-dimensional structure of 4-amino-4-deoxychorismate lyase from Escherichia coli.

Tadashi Nakai; Hisashi Mizutani; Ikuko Miyahara; Ken Hirotsu; Sou Takeda; Kwang-Hwan Jhee; Tohru Yoshimura; Nobuyoshi Esaki

Biochemistry | 2001

The Reaction of Yeast Cystathionine β-Synthase Is Rate-Limited by the Conversion of Aminoacrylate to Cystathionine†

Kwang-Hwan Jhee; Dimitri Niks; Peter McPhie; Michael F. Dunn; Edith Wilson Miles

Biochemistry | 1998

Mutations in the contact region between the alpha and beta subunits of tryptophan synthase alter subunit interaction and intersubunit communication.

Roger S. Rowlett; Li-Hong Yang; S. Ashraf Ahmed; Peter McPhie; Kwang-Hwan Jhee; Edith Wilson Miles

Bioscience, Biotechnology, and Biochemistry | 1996

Stereospecificity for the Hydrogen Transfer and Molecular Evolution of Pyridoxal Enzymes

Tohru Yoshimura; Kwang-Hwan Jhee; Kenji Soda

Journal of Biological Chemistry | 1998

MUTATION OF AN ACTIVE SITE RESIDUE OF TRYPTOPHAN SYNTHASE (BETA -SERINE 377) ALTERS COFACTOR CHEMISTRY

Kwang-Hwan Jhee; Yang Lh; Ahmed Sa; Peter McPhie; Rowlett R; Edith Wilson Miles

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Edith Wilson Miles

National Institutes of Health

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Peter McPhie

National Institutes of Health

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Kenji Soda

Kansai University

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Nobuyoshi Esaki

Kyoto University

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Tohru Yoshimura

Nagoya University

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Warren D. Kruger

Fox Chase Cancer Center

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Dimitri Niks

University of California

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Hyeon-Su Ro

National Institutes of Health

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Michael F. Dunn

University of California

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Ikuko Miyahara

Osaka City University

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