Kyoichi Sakakibara
University of Tokyo
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Featured researches published by Kyoichi Sakakibara.
Japanese Journal of Cancer Research | 1997
Motohiro Kobayashi; Tsugitaka Natsume; Satoru Tamaoki; Jun-ichi Watanabe; Hajime Asano; Takashi Mikami; Katsuhiko Miyasaka; Koichi Miyazaki; Masaaki Gondo; Kyoichi Sakakibara; Shigeru Tsukagoshi
Dolastatin 10, a pentapeptide isolated from the marine mollusk Dolabella auricularia, has antitumor activity. TZT‐1027, a dolastatin 10 derivative, is a newly synthesized antitumor compound. We evaluated its antitumor activity against a variety of transplantable tumors in mice. Intermittent injections of TZT‐1027 were more effective than single or repeated injections in rake with P388 leukemia and B16 melanoma. Consequently, TZT‐1027 shows schedule dependency. TZT‐1027 was effective against P388 leukemia not only when administered i.p., but also when given i.v. However, although TZT‐1027 given i.v. was active against murine solid tumors, TZT‐1027 administered i.p. was ineffective against all the tumors tested with the exception of colon 26 adenocarcinoma. The i.v. injection of TZT‐1027 at a dose of 2.0 mg/Ag remarkably inhibited the growth of three murine solid tumors; colon 26 adenocarcinoma, B16 melanoma and M5076 sarcoma, with T/C values of less than 6%. The antitumor activities of TZT‐1027 against these tumors were superior or comparable to those of the reference agents; dolastatin 10, cisplatin, vincristine, 5‐fluorouracil (5‐FU) and E7010. In experiments with drug‐resistant P388 leukemia, TZT‐1027 showed good activity against cisplatin‐resistant P388 and moderate activity against vincristine‐ and 5‐fluorouracil‐resistant P388, but no activity against adriamycin‐resistant P388. TZT‐1027 was also effective against human xenografts, that is, tumor regression was observed in mice bearing MX‐1 breast and LX‐1 lμng carcinomas. TZT‐1027 at 10 μM almost completely inhibited the assembly of porcine brain microtubules. Therefore, its mechanism of antitumor action seems to he, at least in part, ascrihable to the inhibition of microtubule assembly. Because of its good preclinical activity, TZT‐1027 has been entered into phase I clinical trials.
Archive | 1992
Kyoichi Sakakibara; Masaaki Sunstage-Ryokuentoshi Gondo; Koichi Miyazaki
Archive | 1995
Kyoichi Sakakibara; Masaaki Gondo; Koichi Miyazaki
Archive | 1994
Kyoichi Sakakibara; Masaaki Sunstage-Ryokuentoshi Gondo; Koichi Miyazaki; Takeshi Ito; Akihiro Sugimura; Motohiro Kobayashi
Archive | 1979
Kyoichi Sakakibara; Hideaki Manita; Masaaki Gondo; Haruo Yamashita
Archive | 1992
Kyoichi Sakakibara; Masaaki Gondo; Koichi Miyazaki
Chemical & Pharmaceutical Bulletin | 1988
Haruo Yamashita; Nobuyoshi Minami; Kyoichi Sakakibara; Susumu Kobayashi; Masaji Ohno
Archive | 1979
Kyoichi Sakakibara; Hideaki Manita; Masaaki Gondo; Haruo Yamashita
Archive | 1996
Kyoichi Sakakibara; Masaaki Sunstage-Ryokuentoshi Gondo; Koichi Miyazaki; Takeshi Ito; Akihiro Sugimura; Motohiro Kobayashi
The Journal of Antibiotics | 1987
Haruo Yamashita; Nobuyoshi Minami; Kyoichi Sakakibara; Susumu Kobayashi; Masaji Ohno; Masa Hamada; Hamao Umezawa