Kyoko Iida
University of Tsukuba
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Featured researches published by Kyoko Iida.
International Archives of Allergy and Immunology | 1978
Kazuyoshi Nagaki; Kyoko Iida; Mieko Okubo; Shinya Inai
The reaction mechanisms of β 1H were studied. The generation of alternative pathway C3 and C5 convertases on the cell surface as well as in the fluid phase was inhibited by
Immunochemistry | 1976
Kyoko Iida; Teizo Fujita; Shinya Inai; Makoto Sasaki; Taiji Kato; Kunihiko Kobayashi
Abstract Complement fixing abilities of IgA and its fragments chemically aggregated were tested. Both IgA1 and IgA2 myeloma proteins fixed considerable amount of human complement. IgA2 fixed complement more efficiently than IgA1 did. Fc and F(ab′) 2 of IgA1 were more active than undigestived IgA1, and their activities were comparable to that of Fc of IgG, whereas the activity of F(ab′) 2 of IgA2 was weak. Complement component profiles of human serum treated either IgA or its fragments revealed that the classical pathway of the complement system was activated.
Journal of Immunological Methods | 1974
Kazuyoshi Nagaki; Kyoko Iida; Shinya Inai
Abstract By reacting EA with serum in the presence of triethylenetetramine-N,N,N′,N″,N‴,N‴-hexa-acetic acid (TTHA), active and stable cellular intermediate of immune hemolysis, EAC14, was successfully prepared. This method does not require isolated components of complement and is applicable to prepare EAC14hu.
Journal of Immunological Methods | 1987
Kyoko Iida; Katsuyuki Mitomo; Teizo Fujita; Noboru Tamura
A solid-phase anti-C3 assay detecting immune complexes associated with C3 fragments is described. Two monoclonal antibodies against C3 fragments are used; one recognizes an epitope expressed on C3b, C3c and C3i, the other recognizes an epitope expressed on C3dg and iC3b. Combining these monoclonal anti-C3s with antibodies against class-specific immunoglobulins in enzyme-linked immunosorbent assay (ELISA), immune complexes (ICs) are detected in six distinguished forms; C3b-IgG-IC, iC3b/C3dg-IgG-IC, C3b-IgA-IC, iC3b/C3dg-IgA-IC, C3b-IgM-IC and iC3b/C3dg-IgM-IC. About three-fourths of the plasma samples from patients with active SLE or IgA-nephritis were found positive in one or more types of ICs. IgA-type ICs were found very frequently in patients with autoimmune or renal diseases.
Clinical Immunology and Immunopathology | 1986
Kyoko Iida; Akio Koyama; Hideko Nakamura; Inage H; Mitsuhara Narita; Shizuo Tojyo; Javier Kamisato; Teizo Fujita; Noboru Tamura
The number of complement receptor for C3b (CR1) molecules in erythrocytes from patients with renal diseases was measured by an immunoradiometric assay using monoclonal antibodies against CR1. IgA nephritis patients with high serum creatinine value (Scr) showed markedly elevated levels of CR1, whereas patients with normal Scr had normal CR1 levels. A similar increase in CR1 number was observed in membranoproliferative glomerular nephritis with high Scr. CR1 of these patients functioned normally as a cofactor of C3b inactivator in cleaving immune complex-bound C3b. In contrast, a high frequency (5/6) of negative staining of glomerular CR1 was observed in IgA nephritis patients with high Scr by immunofluorescence study. We postulate that the disease-associated, acquired factors at least in part contribute to the abnormal expression of CR1: elevated levels in erythrocytes and defective expression on glomeruli.
International Archives of Allergy and Immunology | 1978
Jinan Sheena; Christopher J. Meade; Peyton A. Eggleston; Owen Hendley; Jack M. Gwaltney; Eggleston Aw; Byrd S. Leavell; Vali Kermani-Arab; Janet L. Roberts; Gerrie A. Leslie; Arja Uotila; Anne Hamblin; D.C. Dumonde; Kai Krohn; Kazuyoshi Nagaki; Kyoko Iida; Mieko Okubo; Shinya Inai; Reginald M. Lambert; James R. Dolan; Kathryn R. Zelenski; Chandra G. Agrawal; Swami P. Gupta; U. C. Chaturvedi; Mitra Mk; Gupta Nn; T.M. Lin; Frederik Sperling; Tsue-Ming Lin; Seymour P. Halbert
This article gives the decisions of the WHO nomenclature committee on leukocyte antigens, in particular concerning (a) the upgrading of certain HLA-A and HLA-B specificities to full HLA status, (b) the designation of new provisional specificities of the HLA-B, HLA-C, and HLA-D loci, and (c) the establishment of a nomenclature for the new specificities identified by serological techniques on B lymphocytes.
International Archives of Allergy and Immunology | 1974
Kazuyoshi Nagaki; Kyoko Iida; Shinya Inai
Journal of Biochemistry | 1977
Yuji Fukumoto; Shinya Inai; Kazuyoshi Nagaki; Kyoko Iida; Eiji Yamagami; Yasuhiko Masuho; Tsuneo Watanabe
International Archives of Allergy and Immunology | 1978
Kazuyoshi Nagaki; Kyoko Iida; Mieko Okubo; Shinya Inai
International Archives of Allergy and Immunology | 1974
I.R. Tizard; W.L. Holmes; Ernst H. Beutner; Eric W. Beutner; Samuel M. Peck; J.R. Frey; R.H. Persellin; R.J. Chang; Burton Zweiman; Michael F. Miller; Gerrie A. Leslie; Louis N. Martin; M. M. Roberts; Ann Stevenson; Eleanor M. Bass; B.A.J. Walters; J.E.D. Chick; W.J. Halliday; Margaret Ward Orsini; A.A. Blazkovec; R.St.C. Dwyer; J.L. Turk; S. Darougar; F. Hahn; A. Jobke; Kazuyoshi Nagaki; Kyoko Iida; Shinya Inai; J.D. Kelly; R.J. Love