Kyoko Yokoi
Nagoya City University
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Featured researches published by Kyoko Yokoi.
Brain & Development | 2010
Sumio Fukuda; Kyoko Yokoi; Kyoko Kitajima; Yuko Tsunoda; Naofumi Hayashi; Seiki Shimizu; Tomoya Yoshida; Naoki Hamajima; Isamu Watanabe; Haruo Goto
Cerebral white matter injury, usually called periventricular leukomalacia (PVL), is the most common form of injury to preterm infants that is associated with adverse motor and cognitive outcomes. Intrauterine infection may be an important etiological factor in PVL, and premature rupture of the membranes (PROM) can be identified antepartum. In order to investigate the pathophysiology of cerebral white matter injury induced by PROM, the cerebral blood flow (CBF) of the internal carotid artery and the vertebral artery was measured by neck ultrasonography. The CBF was determined in 84 low-birth-weight infants with gestational ages ranging from 24 to 35 weeks, including 71 infants without PROM and 13 infants with PROM. The mean blood flow velocity and diameter of each vessel were measured on postnatal days 0-70. The intravascular flow volume was determined by calculating the mean blood flow velocity and the cross-sectional area. The mean blood pressures were recorded, and the ejection fraction was determined. The total cerebral blood flow (CBF) was significantly lower in infants with PROM than in infants without PROM from day 10 to day 70. The ejection fraction was significantly higher in infants with PROM than in infants without PROM on days 0, 5, 10, 21, and 42. There was no difference in the mean blood pressure between infants with PROM and infants without PROM. The results of the present study suggest that PROM may decrease cerebral blood flow after the birth.
Brain & Development | 2016
Yuka Ashikari; Satoru Kobayashi; Akari Tago; Mizuki Yoneyama; Midori Ito; Keiko Fukuda; Yoshifumi Mizuno; Yuko Tsunoda; Seiki Shimizu; Kyoko Yokoi; Naomi Kamioka; Naoki Hamajima; Satoshi Suzuki
Here, we report a 5-year-old girl with Guillain-Barré syndrome who presented with a chief complaint of pain in the extremities, which was followed by neck stiffness. Bladder dysfunction was found, which required catheterization. Magnetic resonance imaging revealed marked enhancement of the nerve roots in the cauda equina on T1-weighted imaging after gadolinium injection, and nerve conduction studies led to a diagnosis of Guillain-Barré syndrome. Her symptoms improved after intravenous immunoglobulin therapy, but her neck stiffness remained 16 days after admission. Four weeks after admission, she could walk without support. As patients with signs of meningeal irritation may be diagnosed with other diseases, such as meningitis, it is important to recognize atypical cases of pediatric Guillain-Barré syndrome to achieve early diagnosis and treatment.
Brain & Development | 2011
Sumio Fukuda; Kyoko Yokoi; Satoshi Suzuki; Haruo Goto
Periventricular leukomalacia is a major form of neuropathology in preterm infants that is associated with adverse motor and cognitive outcomes. The volume of periventricular white matter and corpus callosum has been reported to be diminished in infants with PVL, and the degree of the volume loss is correlated with the severity of neurological impairment. The thalamic index was calculated from the length, height, width of the thalamus, and thalamic volume was calculated using the formula for an ovoid in 62 low birth weight infants with gestational ages of 24-35weeks, 51 control infants (cerebral palsy, 1 case), and 11 infants diagnosed with PVL (cerebral palsy, 7 cases) at postnatal days0-70. The indices of the right thalamus were lower in infants with PVL than in control infants from day0 to day70, and there were significant differences on days 21, 28, 35, 42, 49, 56, 63, and 70. The indices of the left thalamus were lower in infants with PVL than in control infants from day0 to day70, and there were significant differences on days 21, 28, 35, 42, 49, 56, 63, and 70. The results of the present study suggest that the volume of the thalami is reduced and that thalamic injury is associated with white matter lesions in infants with PVL.
Pediatrics International | 2017
Toshihiko Nakamura; Hideomi Asanuma; Satoshi Kusuda; Ken Imai; Shigeharu Hosono; Ryota Kato; Satoshi Suzuki; Kyoko Yokoi; Minoru Kokubo; Shingo Yamada; Takashi Kamohara
We measured changes in the blood level of high‐mobility group box‐1 (HMGB‐1) at 24 h intervals in neonates treated with brain/body hypothermia (body hypothermia therapy: BHT) for hypoxic–ischemic encephalopathy (HIE), to evaluate the usefulness of HMGB‐1 level for determining outcomes.
Pediatrics International | 2017
Atsushi Nakayama; Makoto Oshiro; Yasumasa Yamada; Tetsuo Hattori; Yasuhiro Wakano; Seiji Hayashi; Minoru Kokubo; Koji Takemoto; Shigeru Honda; Kuniko Ieda; Hikaru Yamamoto; Masanori Kouwaki; Kyoko Yokoi; Osamu Shinohara; Takenori Kato; Masafumi Miyata; Taihei Tanaka; Masahiro Hayakawa
Hydrops fetalis (HF) has a low survival rate, particularly in the case of preterm birth. In addition, the severity index of HF has not been fully investigated yet. The aim of this study was to clarify the prognostic factors of HF with pleural effusion.
Brain & Development | 2017
Yuka Ashikari; Satoru Kobayashi; Akari Tago; Mizuki Yoneyama; Midori Ito; Keiko Fukuda; Yoshifumi Mizuno; Yuko Tsunoda; Seiki Shimizu; Kyoko Yokoi; Naomi Kamioka; Naoki Hamajima; Satoshi Suzuki
We thank Dr. Rebai and colleagues for their interest in our case report ‘‘A case of Guillain–Barré syndrome with meningeal irritation” [1]. They presented a 2-yearold girl diagnosed with Guillain–Barré syndrome (GBS) and presenting with an extremely painful stiff neck with retrocollis, tetraparesis, and generalized areflexia on neurological examination. In their case, enhancement of the medullary cone and cauda equine was revealed by gadolinium images, and the cerebrospinal fluid was high in protein and had a normal cell count, which were compatible with GBS. Although atypical signs of GBS, such as meningeal irritation, have been reported [2,3], a case of GBS with meningeal irritation might be suspected to be bacterial meningitis at first, such as in our case. Neck stiffness is uncommon in GBS in the pediatric population, despite previous reports of it being present in 16 of 46 cases [4], as well as in 38% of children aged <6 years old [5] who were diagnosed with GBS with accompanying neck stiffness. For early diagnosis and treatment, case reports of GBS with neck stiffness, such as that by Dr. Rebai and our report, might be important.
Pediatrics International | 2016
Yoshifumi Mizuno; Kyoko Yokoi; Satoshi Suzuki
There was a rubella epidemic in Japan in 2012–2013, which led to an increased number infants being born with congenital rubella syndrome (CRS). Symptoms of CRS are varied and include cataracts, congenital heart disease, and hearing impairment, but case reports of CRS complicated by interstitial pneumonia are rare. We report the case of a patient with CRS who died of respiratory failure caused by interstitial pneumonia. Thrombocytopenia had been present for approximately 1 month after birth, and the patient presented with sudden lung hemorrhage at 64 days old. Thereafter, respiratory condition deteriorated, and the patient died at 107 days old. Given that infants with CRS who have thrombocytopenia and interstitial pneumonia have a high risk of death, they should be monitored carefully for potential complications.
Rapid Communications in Mass Spectrometry | 2007
Yasuhiro Maeda; Tetsuya Ito; Atsuko Suzuki; Yukihisa Kurono; Akihito Ueta; Kyoko Yokoi; Satoshi Sumi; Hajime Togari; Naruji Sugiyama
Journal of Chromatography B | 2008
Yasuhiro Maeda; Tetsuya Ito; Hironori Ohmi; Kyoko Yokoi; Yoko Nakajima; Akihito Ueta; Yukihisa Kurono; Hajime Togari; Naruji Sugiyama
Tohoku Journal of Experimental Medicine | 2007
Kyoko Yokoi; Tetsuya Ito; Yasuhiro Maeda; Yoko Nakajima; Akihito Ueta; Takayasu Nomura; Norihisa Koyama; Ineko Kato; Satoshi Suzuki; Yukihisa Kurono; Naruji Sugiyama; Hajime Togari