Kyung Sook Choi

Cancer Worry Experiences among Colorectal Cancer Patients and Families who have a Family History of Colorectal Cancer

주요어: 대장암, 조기 암 검진, 암 예방, 가족 *본 논문은 2011년도 정부의 재원으로 한국 연구재단의 지원에 의하여 연구되었음. * This work was supported the National Research Foundation of Korea funded by the Korea government (2012-0006861). Address reprint requests to: Jun, Myunghee College of Nursing, University of Wisconsin-Milwaukee, Milwaukee, USA Tel: +1-414-639-5562 Fax: +82-2-824-7961 E-mail: jun2@uwm.edu 투 고 일: 2013년 10월 8일 심사완료일: 2013년 11월 24일 게재확정일: 2013년 12월 4일 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 가족력을 지닌 대장암 환자와 가족의 암 염려 경험

Experiences of Prenatal Genetic Screening and Diagnostic Testing Among Pregnant Korean Women of Advanced Maternal Age

Purpose: This study explored the experiences of Korean women of advanced maternal age undergoing prenatal genetic screening and diagnostic testing. Design: A descriptive, qualitative design was used to guide the study. Method: Ten participants were purposely recruited from a large metropolitan Korean hospital for clinical observations and individual, semistructured interviews. The content analysis method was used to analyze field notes and interview transcripts. Findings: Three themes emerged: reacting to an unfavorable screening result, dealing with the anticipated consequences of diagnostic testing, and realistically embracing the unborn child. Conclusions: The findings of this study inform the development of tailored interventions aimed at reducing the heavy emotional burdens placed on pregnant women and the stigma of bearing children with genetic conditions. Clear reciprocal communication and shared decision making should be promoted in the day-to-day practice of delivering health care for pregnant Korean women.

Identifying Perceptions of Health Professionals Regarding Deathbed Visions and Spiritual Care in End-of-Life Care: A Delphi Consensus Study

The final hours before death can be the most significant time for the dying. Adequate preparation for death can help reduce patients’ fears. Research on end-of-life experiences suggests that deathbed visions are not uncommon, but many doctors and nurses find this a difficult subject to approach. A 2-round Delphi method was used to gain a reliable consensus on deathbed visions from experts in end-of-life care. A purposive sample of nurses (n = 18) and doctors (n = 13) was invited from across hospitals and nursing homes to participate in this study. In this Delphi evaluation, the health professionals’ perceptions of the deathbed visions experienced by patients were identified, as well as how these phenomena should be integrated into spiritual care. The research found that healthcare professionals who are experts in end-of-life care tend to remain at the end-of-life care setting while acknowledging human spirituality as part of a peaceful death. However, they tend to not make conclusions about how death visions should be classified. This Delphi study was an attempt to identify a consensus on spiritual care including deathbed visions in end-of-life care among healthcare professionals.

15P Change of mTOR, p6, NBR1 and LC3A/B-I/II in A549 cells treated with graphene oxides.

Background: Measuring levels of ligands in peripheral blood representing systemic circulation and in blood isolated from tumour vascular bed accompanied by evaluation of binding receptor expression in tumour tissue gives insight into cancerogenesis. We have incorporated this research strategy into surgical practice to investigate the role of CXC chemokines as potential biomarkers of lung cancer. Methods: The study recruited 40 patients (mean age 62±10.4) with primary NSCLC ranging from stage IA to IIB undergoing anatomical pulmonary resection between June 2010 and October 2014. Blood samples from peripheral vein and from pulmonary vein draining tumour vascular bed were collected at the time of surgery. Levels of CXC chemokine ligands (CXCL) potentially involved in cancerogenesis – CXCL1, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8, CXCL9, CXCL10, CXCL11 and CXCL12 were measured using ELISA. CXCL gradients were calculated. Corresponding CXC chemokine receptor (CXCR) expression – CXCR1, CXCR2, CXCR3 and CXCR4 was evaluated in resected tumour by immunohistochemistry and analysed semiquantitatively (expression intensity scale 0–3). Prognostic value of CXCL levels and CXCR expression was assessed evaluating relapse time. Paired two-tailed t-test was used to compare CXCL levels and Pearson test was used to assess statistical relationship between CXCL levels and CXCR expression. Results: Statistically significant difference between circulating CXC levels was found for CXCL4 (p < 0.001), CXCL5 (p < 0.05), CXCL7 (p < 0.001). Moderate statistically significant correlation was found between CXCL10, CXCL11 gradient and stromal expression of CXCR3. CXCL1, CXCL4 and CXCL10 gradients correlated with relapse (r = 0.38, r = 0.39, r = 0.35, p < 0.05). CXCR2 expression in tumour tissue correlated with relapse (r = 0.44, p < 0.05) and mortality (r = 0.45, p < 0.05). Conclusions: Our approach has facilitated identifying chemokine ligands and receptors potentially involved in NSCLC tumour metabolism and improved understanding of a complex and variable background of proteomic profile in lung cancer leading to biomarker discovery. Legal entity responsible for the study: Pauls Stradins Clinical University Hospital Funding: Pauls Stradins Clinical University Hospital Disclosure: All authors have declared no conflicts of interest.