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L. Atwell

United States Public Health Service

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Journal of Medicinal Chemistry | 1981

Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines.

Rösner M; Capraro Hg; Arthur E. Jacobson; L. Atwell; Arnold Brossi; Maria A. Iorio; Williams Th; Sik Rh; Colin F. Chignell

Journal of Medicinal Chemistry | 1984

Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones.

Helmut Schmidhammer; Lislott Aeppli; L. Atwell; Florian Fritsch; Arthur E. Jacobson; Michaela Nebuchla; Guenther Sperk

Journal of Medicinal Chemistry | 1983

Biological effects of modified colchicines. 2. Evaluation of catecholic colchicines, colchifolines, colchicide, and novel N-acyl- and N-aroyldeacetylcolchicines.

Arnold Brossi; Padam N. Sharma; L. Atwell; Arthur E. Jacobson; Maria A. Iorio; Marisa Molinari; Colin F. Chignell

Journal of Pharmaceutical Sciences | 1972

Analgesic Activity as Determined by the Nilsen Method

Theodore D. Perrine; L. Atwell; Ira B. Tice; Arthur E. Jacobson; Everette L. May

ChemInform | 1981

STRUCTURE-ACTIVITY RELATIONSHIPS OF OXYGENATED MORPHINANS. II. SYNTHESIS AND BIOLOGICAL PROPERTIES OF 4-METHOXYMORPHINAN-6-ONES WITH NARCOTIC ANTAGONIST SIDE-CHAINS ON NITROGEN

Arnold Brossi; Helmut Schmidhammer; Arthur E. Jacobson; L. Atwell

NIDA research monograph | 1982

Structure-activity relationships of oxygenated morphinans. III. An exploration of the effect of the aromatic oxygen and 6-keto group on antinociceptive activity, receptor affinity, and narcotic antagonism.

Arthur E. Jacobson; Helmut Schmidhammer; Hsu Fl; Rozwadowska; L. Atwell; Arnold Brossi; Aceto; Louis S. Harris; Katz Jl; James H. Woods; Fedor Medzihradsky

ChemInform | 1981

STRUCTURE-ACTIVITY RELATIONSHIPS OF OXYGENATED MORPHINANS. I. 4-MONO- AND 3,4-DIMETHOXY-N-METHYLMORPHINANS AND -N-METHYLMORPHINAN-6-ONES WITH UNUSUALLY HIGH ANTINOCICEPTIVE POTENCY

Arthur E. Jacobson; Fu-Lian Hsu; M. D. Rozwadowska; Helmut Schmidhammer; L. Atwell; Arnold Brossi; F. Medzihradsky

ChemInform | 1985

SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS. 1. HIGHLY POTENT OPIOID AGONISTS IN THE SERIES OF (-)-14-METHOXY-N-METHYLMORPHINAN-6-ONES

Helmut Schmidhammer; L. Aeppli; L. Atwell; F. Fritsch; Arthur E. Jacobson; M. Nebuchla; G. Sperk

ChemInform | 1984

BIOLOGICAL EFFECTS OF MODIFIED COLCHICINES. 2. EVALUATION OF CATECHOLIC COLCHICINES, COLCHIFOLINES, COLCHICIDE, AND NOVEL N-ACYL- AND N-AROYLDEACETYLCOLCHICINES

Arnold Brossi; P. N. Sharma; L. Atwell; Arthur E. Jacobson; M. A. Iorio; M. Molinari; C. F. Chignell

ChemInform | 1983

STRUCTURE-ACTIVITY RELATIONSHIP OF OXYGENATED MORPHINANS. VII. 5-METHYLATED AND 14-HYDROXY-SUBSTITUTED AGONISTS AND ANTAGONISTS OF THE 4-HYDROXY- AND 3,4-DIOXYGENATED 6-MORPHINANONE SERIES

Arnold Brossi; L. Atwell; Arthur E. Jacobson; M. D. Rozwadowska; Helmut Schmidhammer; J. L. Flippen-Anderson; Richard Gilardi

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Arthur E. Jacobson

National Institutes of Health

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Arnold Brossi

National Institutes of Health

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Helmut Schmidhammer

University of Innsbruck

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Colin F. Chignell

National Institutes of Health

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Maria A. Iorio

Istituto Superiore di Sanità

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Everette L. May

United States Public Health Service

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Fedor Medzihradsky

University of Michigan

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Fu-Lian Hsu

National Institutes of Health

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Ira B. Tice

United States Public Health Service

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James H. Woods

University of Michigan

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