L. Hanlon

OMC: An Optical Monitoring Camera for INTEGRAL Instrument description and performance

The Optical Monitoring Camera (OMC) will observe the optical emission from the prime targets of the gamma- ray instruments onboard the ESA mission INTEGRAL, with the support of the JEM-X monitor in the X-ray domain. This capability will provide invaluable diagnostic information on the nature and the physics of the sources over a broad wavelength range. Its main scientific objectives are: (1) to monitor the optical emission from the sources observed by the gamma- and X-ray instruments, measuring the time and intensity structure of the optical emission for comparison with variability at high energies, and (2) to provide the brightness and position of the optical counterpart of any gamma- or X-ray transient taking place within its field of view. The OMC is based on a refractive optics with an aperture of 50 mm focused onto a large format CCD (1024 2048 pixels) working in frame transfer mode (1024 1024 pixels imaging area). With a field of view of 5 5 it will be able to monitor sources down to magnitude V = 18. Typical observations will perform a sequence of dierent integration times, allowing for photometric uncertainties below 0.1 mag for objects with V 16.

Tumor delineation using PET in head and neck cancers: Threshold contouring and lesion volumes

Tumor boundary delineation using positron emission tomography (PET) is a promising tool for radiation therapy applications. In this study we quantify the uncertainties in tumor boundary delineation as a function of the reconstruction method, smoothing, and lesion size in head and neck cancer patients using FDG-PET images and evaluate the dosimetric impact on radiotherapy plans. FDG-PET images were acquired for eight patients with a GE Advance PET scanner. In addition, a 20 cm diameter cylindrical phantom with six FDG-filled spheres with volumes of 1.2 to 26.5 cm3 was imaged. PET emission scans were reconstructed with the OSEM and FBP algorithms with different smoothing parameters. PET-based tumor regions were delineated using an automatic contouring function set at progressively higher threshold contour levels and the resulting volumes were calculated. CT-based tumor volumes were also contoured by a physician on coregistered PET/CT patient images. The intensity value of the threshold contour level that returns 100% of the actual volume, I(V100), was measured. We generated intensity-modulated radiotherapy (IMRT) plans for an example head and neck patient, treating 66 Gy to CT-based gross disease and 54 Gy to nodal regions at risk, followed by a boost to the FDG-PET-based tumor. The volumes of PET-based tumors are a sensitive function of threshold contour level for all patients and phantom datasets. A 5% change in threshold contour level can translate into a 200% increase in volume. Phantom data indicate that I(V100) can be set as a fraction, f, of the maximum measured uptake. Fractional threshold values in the cylindrical water phantom range from 0.23 to 0.51. Both the fractional threshold and the threshold-volume curve are dependent on lesion size, with lesions smaller than approximately 5 cm3 displaying a more pronounced sensitivity and larger fractional threshold values. The threshold-volume curves and fractional threshold values also depend on the reconstruction algorithm and smoothing filter with more smoothing requiring a higher fractional threshold contour level. The threshold contour level affects the tumor size, and therefore the ultimate boost dose that is achievable with IMRT. In an example head and neck IMRT plan, the D95 of the planning target volume decreased from 7770 to 7230 cGy for 42% vs. 55% contour threshold levels. PET-based tumor volumes are strongly affected by the choice of threshold level. This can have a significant dosimetric impact. The appropriate threshold level depends on lesion size and image reconstruction parameters. These effects should be carefully considered when using PET contour and/or volume information for radiotherapy applications.

INTEGRAL upper limits on gamma-ray emission associated with the gravitational wave event GW150914

Using observations of the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL), we place upper limits on the gamma-ray and hard X-ray prompt emission associated with the gravitational wave event GW150914, which was discovered by the LIGO/Virgo Collaboration. The omnidirectional view of the INTEGRAL/SPI-ACS has allowed us to constrain the fraction of energy emitted in the hard X-ray electromagnetic component for the full high-probability sky region of LIGO triggers. Our upper limits on the hard X-ray fluence at the time of the event range from

Temporal properties of gamma ray bursts as signatures of jets from the central engine

{F}_{\gamma }=2\times {10}^{-8}

Gamma-Ray-Burst Spectral Shapes from 2 keV to 500 MeV

erg cm(−)(2) to

The e-ASTROGAM mission

{F}_{\gamma }={10}^{-6}

INTEGRAL spectrometer SPI’s GRB detection capabilities : GRBs detected inside SPI’s FoV and with the anticoincidence system ACS

erg cm(−)(2) in the 75 keV–2 MeV energy range for typical spectral models. Our results constrain the ratio of the energy promptly released in gamma-rays in the direction of the observer to the gravitational wave energy E

Global characteristics of GRBs observed with INTEGRAL and the inferred large population of low-luminosity GRBs ,

{}_{\gamma }/

Temporal properties of the short gamma-ray bursts

E

Flares from a candidate Galactic magnetar suggest a missing link to dim isolated neutron stars

{}_{\mathrm{GW}}\lt {10}^{-6}