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Dive into the research topics where L. Heemstra is active.

Publication


Featured researches published by L. Heemstra.


Value in Health | 2015

Payer/Hta Requirements In Metastatic Breast Cancer

S. Holmstrom; Pj Kooreman; A. Van Engen; L. Heemstra; A Novak; Shevani Naidoo

INTRODUCTION • Triple-negative breast cancer (TNBC) represents 10%–20% of invasive breast cancers1 and has a very poor prognosis.2 There is a particular unmet need in TNBC, with a lack of clinically established targeted therapies3; chemotherapy is the only option for metastatic TNBC.4 • To facilitate access to new treatments, it is increasingly important to understand payer evidence needs in addition to regulatory evidence requirements.5 • Traditionally, payers focus on hard endpoints such as overall survival (OS), and recommendations for reimbursement would ideally be supported by statistically significant improvement in OS. However, this is sometimes difficult due to long follow-up durations and post-study treatment.


Value in Health | 2015

Hierarchy of clinical endpoints in HTA decision making in Oncology

J Kreeftmeijer; J. Ryan; A. Van Engen; L. Heemstra


Value in Health | 2013

Dealing with Zero Cells in Sparse Networks in Bayesian Network Meta-Analysis

Cristina Ivanescu; K. Skaltsa; L. Heemstra; A. Van Engen


Value in Health | 2015

Predictive Analysis of Factors Influencing Health Technology Assessment Recommendation: A Literature Review

N Bossers; A. Van Engen; L. Heemstra


Value in Health | 2015

The Impact of Neutralizing Antibody Testing on The Cost-Effectiveness of Injectable Disease Modifying Treatments for Relapsing Remitting Multiple Sclerosis

M. Andreykiv; A Plich; A. Prüfert; L. Heemstra; A. Van Engen


Value in Health | 2015

Impact of tolerability profiles on HTA decision making in Oncology

J Kreeftmeijer; J. Ryan; A. Van Engen; L. Heemstra


Value in Health | 2015

To What Extent Do Payers' Assessment Of Clinically Relevant Outcomes Align With Clinicians In Oncology?

J. Ryan; A. Van Engen; L. Heemstra; J Kreeftmeijer


Value in Health | 2015

Understanding Key Drivers of Successful Hta Submission - Developing a Model.

N Bossers; A. Van Engen; L. Heemstra


Value in Health | 2014

Will Value Based Assessment (VBA) Revolutionise The Nice Assessment

L. Heemstra; J.L. Purchase; Engen A. Van


Value in Health | 2014

Does Not Reaching an Agreement on the Final Nice Scope Have Any Impact on The Final Apraisal Outcome

M. Casamayor; L. Heemstra; Engen A. Van

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