L. K. Vasyanina

Sterically oriented synthesis and structure of new perphosphorylated resorcinarenes

Tetraarylresorcinarenes in a chair conformation of C2h symmetry were synthesized by sterically oriented condensation of aromatic aldehydes with resorcinol and 2-methylresorcinol. By further phosphorylation of resorcinarenes with phosphorous amides perphosphorylated derivatives were obtained with rctt configuration of substituents at internuclear methylidene bridges. Structure of these compounds was proved using NMR spectroscopy and X-ray diffraction analysis.

β-cyclodextrin and its silyl derivative inclusion complexes and conjugates with medicine preparation “Ibuprofen” and its synthetic precursors

A possibility of formation of various inclusion complexes and conjugates of β-cyclodextrin and its silyl derivatives with the medicine preparation “Ibuprofen” and its synthetic precursors in dependence of nature of solvent and size of cyclodextrin cavity is demonstrated.

Cyclic bis-amidophosphites based on 1,6-dihydroxynaphthalene

Phosphorylation of 1,6-dihydroxynaphthalene with various triamidophosphites gives 2: 2 cyclic adducts with the 1,6′,1′,6-bonding of the naphthalenediyl moieties through the amidophosphite bridges.

Exhaustive acylation of dihydroquercetin

Reaction of dihydroquercetin with acid chlorides of higher and functionalized carboxylic acids was studied with the purpose of creation of new pharmaceuticals.

dihydroquercetin in the reactions with phosphorous acid hexaethyltriamide

The possibility was demonstrated and conditions were developed of a directional phosphorylation of dihydroquercetin flavonoid with phosphorous hexaethyltriamide. The chemical properties of the obtained compounds of trivalent phosphorus are currently under investigation.

Dioxaphosphacyclanes. Synthesis and Chemical Properties

Abstract1,5- and 2,7-dihydroxynaphthalenes were reacted with P(III) amides to obtain naphthocyclophanes. The structures and chemical properties of the products were studied.

NMR study of inclusion complexes formation between amphiphilic dimeric β-cyclodextrin derivative and some pharmacologically important compounds

With the use of monotosyl β-cyclodextrin derivative and 1,6-hexanediamine the new dimeric (bridged) amphiphilic derivative was obtained, and the opportunity to form on its base inclusion complexes of “guest–host” type with some pharmacologically important compounds was demonstrated by 1H and 13C NMR spectroscopy.

Synthesis of dinaphthylmethane derivatives containing carbamothioyloxy and carbamoylsulfanyl groups

Chemical modification of 1,1′-methylenedinaphthalen-2-ol and 1,1′-methylenedinaphthalen-2,7-diol, including thiocarbamoylation, Newman-Kwart rearrangement, and hydride reduction, afforded dinaphthylmethane derivatives containing carbamothioyloxy, carbamoylsulfanyl, and sulfanyl groups.

Pre-organized oligomodified resorcinarene ligands. Preparation, structure, and complex formation

Interaction of various conformations of resorcinarenes with carbamoyl chloride, thiocarbamoyl chloride, and trifluoromethanesulfonic acid anhydride has resulted in a series of derivatives with certain pre-organization of the macrocyclic scaffold and the immobilized electron-donating groups. Complex formation of the selected prepared compounds towards Pd(II) derivatives has been studied.

Aminomethylation of dihydroquercetin

At present, it is necessary to develop the synthesis of a large number of aminomethylated dihydroquerce tin derivatives of various structure to conduct extended biological testing. We used secondary amines (diisopropylamine and N methylbenzylamine) and primary amine, amy lamine, as the amine components in the Mannich reaction. It should be noted that primary and secondary amines form strong complexes with dihydroquercetin as pale yellow powders. The structure of the complexes was confirmed by 1H and 13C NMR, while the compo sition was corroborated by elemental analysis. It is interesting that the complexes always include only one amine molecule at any flavonoid : amine molar ratios.