L. M. Schiffer

Erythropoietic and Reticuloendothelial Function in Bone Marrow in Dogs

Erythropoietic and reticuloendothelial functions in bone marrow were found to be identically distributed between various bones and within individual bones in the dog.

Studies on lymphocytes IX. The survival of autotransfused labeled lymphocytes in chronic lymphocytic leukemia

Resume 1.1. Les lymphocytes de 4 patients, atteints de leucemie lymphoide chronique, ont ete marques, in vitro, par la cytidine 3 H. Vingt-quatre a 48 heures apres autotransfusion de ces lymphocytes marques, on a retrouve, dans le sang circulant, 25–60% des cellules marques. Lindex de marquage etait considerablement plus bas dans la moelle osseuse et dans les ganglions quil ne letait, au meme moment, dans le sang. 2.2. On a observe, dans les premieres heures, une disparition rapide dune fraction des cellules marquees du sang, et on a interprete cette disparition comme resultant dun equilibre partiel des lymphocytes du sang avec un pool extravasculaire, ou dun equilibre total avec un pool intravasculaire non circulant. 3.3. Une partie des lymphocytes marques resta dans le sang, pendant toute la periode dobservation. Ceci semble indiquer un sejour prolonge, dans le sang, dune fraction, ou de la totalite, des lymphocytes de la leucemie lymphoide chronique. 4.4. Ces resultats sont discutes en raison dune eventuelle application de lirradiation extracorporelle au traitement de la leucemie lymphoide chronique.

Studies on Lymphopoiesis. VII. Size Distribution of Bovine Thoracic Duct Lymphocytes.

Summary Size distribution studies based upon cell volumes of pure thoracic duct lymphocytes of normal young calves indicate the existence of two populations of cells and delineate the size and range of each.

Attempts at Isolation of Lymphocytosis-Producing Factor from Supernatant Fluids of Bordetella pertussis Cultures

Summary The B. pertussis culture supernatant fluid possessing lymphocytosis-producing factor, histamine-sensitizing factor, lethal and hypoglycemia-producing factors was subjected to Sephadex G-10 and Bio Gel P-100 column chromatography. When chromatographic fractionation was carried out at 4° some fractions, found to retain the lym-phocytosis-producing property, had lost the lethal and hypoglycemia producing factors, and had partially lost the histaminesensitizing factor. Observations indicate that lymphocytosis-producing factor is distinct from other toxic factors. We wish to acknowledge the technical assistance of Mr. Gerd Borner.

Cytotoxic Antibody Response to Skin Allografts in Calves Effects of Extracorporeal Irradiation of Lymph

Summary The cytotoxic antibody response to skin allografts was examined in calves which received continuous ECIL for up to 28 days. In 3 calves, which maintained posterior skin grafts until ECIL was discontinued, the antibody response was markedly depressed. Following the termination of ECIL cytotoxicity of the sera increased. It was concluded that the antibody response is propagated throughout the body by radiosensitive cells entering the blood via efferent lymphatics.