L. P. van Minnen
University of Groningen
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Featured researches published by L. P. van Minnen.
Pancreas | 2006
L. P. van Minnen; Vincent B. Nieuwenhuijs; Mt de Bruijn; Andre Verheem; Visser; Je van Dijk; Lma Akkermans; H. G. Gooszen
Objectives: The colon is considered a major source of bacteria causing infection of pancreatic necrosis in acute pancreatitis (AP). Subtotal colectomy before AP in rats reduces mortality, but its role in affecting small bowel flora, bacterial translocation, and infection of pancreatic necrosis is unknown. Our aim was to study these phenomena in rats with AP. Methods: Fifty rats, allocated in 4 groups, underwent 2 laparotomies: group 1, sham laparotomy and saline biliopancreatic duct infusion; group 2, subtotal colectomy and saline infusion; group 3, sham laparotomy and AP (ductal infusion of glycodeoxycholic acid and intravenous cerulein); group 4, subtotal colectomy and AP. Seventy-two hours later, samples were collected for microbiological analysis. Results: Subtotal colectomy caused small bowel bacterial overgrowth with gram-positive cocci (group 1 versus group 2, duodenum: P = 0.030, ileum: P = 0.029). Bacterial counts of gram-negative rods/anaerobes in the duodenum and ileum and pancreatic bacterial counts of rats with colectomy and AP were significantly higher than in rats with AP only (group 3 versus group 4, duodenum: P = 0.040, ileum: P = 0.029, pancreas: P = 0.017). Duodenal bacterial overgrowth and pancreatic infection correlate significantly (r = 0.45, P = 0.004). Conclusions: Subtotal colectomy induces small bowel bacterial overgrowth, which is associated with increased bacterial translocation to the pancreas.
Journal of Plastic Reconstructive and Aesthetic Surgery | 2011
Jaap G.H. Poerink; Moshe Kon; L. P. van Minnen
The current report describes a case of a 16-year-old girl with a rare combination of nasal dysmorphology, anonychia and brachydactyly of hands and feet. The combination of hand and nasal malformations suggested a type B brachydactyly. Genetic investigation, however, revealed Cooks syndrome with unexplained facial dysmorphology. Concerning her cosmetic complaints, options for surgical treatment were discussed. It was decided to treat only the nasal deformity by open rhinoplasty, leaving the nail deformities undisturbed.
European Journal of Gastroenterology & Hepatology | 2006
Femke Lutgendorff; L. P. van Minnen; Harro M. Timmerman; H. G. Gooszen; Lma Akermans
Pancreas | 2007
Femke Lutgendorff; Lena M. Trulsson; L. P. van Minnen; Ger T. Rijkers; Harro M. Timmerman; Hein G. Gooszen; Johan D. Söderholm; L. M. A. Akkermans; Per Sandström
Pancreas | 2007
Femke Lutgendorff; Lena M. Trulsson; L. P. van Minnen; Ger T. Rijkers; Harro M. Timmerman; Hein G. Gooszen; Johan D. Söderholm; L. M. A. Akkermans; Per Sandström
Pancreas | 2007
Femke Lutgendorff; Per Sandström; Lena M. Trulsson; L. P. van Minnen; Ger T. Rijkers; Harro M. Timmerman; Hein G. Gooszen; L. M. A. Akkermans; Johan D. Söderholm
European Journal of Gastroenterology & Hepatology | 2007
L. P. van Minnen; Harro M. Timmerman; W de Jager; Sergey R. Konstantinov; Femke Lutgendorff; A. Verheem; W. Harmsen; M. R. Visser; Hauke Smidt; Hein G. Gooszen; L. M. A. Akkermans; Ger T. Rijkers
Pancreas | 2006
L. P. van Minnen; Andre Verheem; Femke Lutgendorff; Harro M. Timmerman; Ger T. Rijkers; Jakub W. Rychter; H. G. Gooszen; L. M. A. Akkermans; Alfons B.A. Kroese
Gastroenterology | 2006
L. P. van Minnen; Harro M. Timmerman; Femke Lutgendorff; Andre Verheem; Wil Harmsen; Sergey R. Konstantinov; Hauke Smidt; Maarten R. Visser; Ger T. Rijkers; Hein G. Gooszen; L. M. A. Akkermans
European Journal of Gastroenterology & Hepatology | 2005
L. P. van Minnen; Niels G. Venneman; Je van Dijk; H. G. Gooszen; Lma Akkermans; K.J. van Erpecum