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Dive into the research topics where L Van Dyck is active.

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Featured researches published by L Van Dyck.


The EMBO Journal | 1994

Complete DNA sequence of yeast chromosome II

H. Feldmann; Michel Aigle; G. Aljinovic; Bruno André; M.C. Baclet; C. Barthe; Axel Baur; Bécam Am; N. Biteau; Eckhard Boles; T. Brandt; M. Brendel; M. Brueckner; F. Bussereau; C. Christiansen; R. Contreras; M. Crouzet; C. Cziepluch; N. Demolis; T. Delaveau; F. Doignon; H. Domdey; S. Duesterhus; Evelyne Dubois; Bernard Dujon; M. El Bakkoury; K.-D. Entian; M. Feuermann; W. Fiers; G.M. Fobo

In the framework of the EU genome‐sequencing programmes, the complete DNA sequence of the yeast Saccharomyces cerevisiae chromosome II (807 188 bp) has been determined. At present, this is the largest eukaryotic chromosome entirely sequenced. A total of 410 open reading frames (ORFs) were identified, covering 72% of the sequence. Similarity searches revealed that 124 ORFs (30%) correspond to genes of known function, 51 ORFs (12.5%) appear to be homologues of genes whose functions are known, 52 others (12.5%) have homologues the functions of which are not well defined and another 33 of the novel putative genes (8%) exhibit a degree of similarity which is insufficient to confidently assign function. Of the genes on chromosome II, 37‐45% are thus of unpredicted function. Among the novel putative genes, we found several that are related to genes that perform differentiated functions in multicellular organisms of are involved in malignancy. In addition to a compact arrangement of potential protein coding sequences, the analysis of this chromosome confirmed general chromosome patterns but also revealed particular novel features of chromosomal organization. Alternating regional variations in average base composition correlate with variations in local gene density along chromosome II, as observed in chromosomes XI and III. We propose that functional ARS elements are preferably located in the AT‐rich regions that have a spacing of approximately 110 kb. Similarly, the 13 tRNA genes and the three Ty elements of chromosome II are found in AT‐rich regions. In chromosome II, the distribution of coding sequences between the two strands is biased, with a ratio of 1.3:1. An interesting aspect regarding the evolution of the eukaryotic genome is the finding that chromosome II has a high degree of internal genetic redundancy, amounting to 16% of the coding capacity.


Yeast | 1997

An 18.3 kb DNA fragment from yeast chromosome VII carries four unknown open reading frames, the gene for an Asn synthase, remnants of Ty and three tRNA genes.

L Van Dyck; H Tettelin; Bénédicte Purnelle; André Goffeau

An 18·3 kb DNA segment from yeast Saccharomyces cerevisiae chromosome VII encompasses the previously characterized MEP1, NUP57 and PPT1 genes as well as seven new open reading frames (ORFs) of at least 100 residues. G6358 is an ubiquitous glutamine‐dependant asparagine synthase. G6362 is a membrane protein highly homologous to a protein of unknown function in the yeast Schizosaccharomyces pombe. Three ORFs (G6324, G6335 and G6365) have no significant homology with previously reported proteins or characteristic motifs. G6321 and G6359, enclosed in longer ORFs, are not likely to be coding. The segment also contains tRNA genes for Asn, Arg and Ile as well as a sigma element and two solo deltas. ORFs and genetic elements are named according to a preliminary working nomenclature. The sequence is recorded in GenBankTM/EMBL under Accession Number X83099.©1997 John Wiley & Sons, Ltd.


Journal of Biological Chemistry | 1994

PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

Elisabetta Balzi; M Wang; Serge Leterme; L Van Dyck; André Goffeau


Journal of Biological Chemistry | 1994

PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae.

L Van Dyck; D A Pearce; F Sherman


Yeast | 1992

An 11.4 kb DNA segment on the left arm of yeast chromosome II carries the carboxypeptidase Y sorting gene PEP1, as well as ACH1, FUS3 and a putative ARS.

L Van Dyck; Bénédicte Purnelle; J. Skala; André Goffeau


Yeast | 1992

The sequence of a 12 kb fragment on the left arm of yeast chromosome XI reveals five new open reading frames, including a zinc finger protein and a homolog of the UDP-glucose pyrophosphorylase from potato.

Bénédicte Purnelle; J. Skala; L Van Dyck; André Goffeau


Yeast | 1994

Analysis of a 17.4 kb DNA segment of yeast chromosome II encompassing the ribosomal protein L19 as well as proteins with homologies to components of the hnRNP and snRNP complexes and to the human proliferation-associated p120 antigen.

L Van Dyck; Jean-Luc Jonniaux; T de Melo Barreiros; K Kleine; André Goffeau


Yeast | 1992

The sequence of an 8 kb segment on the left arm of chromosome II from Saccharomyces cerevisiae identifies five new open reading frames of unknown functions, two tRNA genes and two transposable elements.

J. Skala; L Van Dyck; Bénédicte Purnelle; André Goffeau


Yeast | 1995

The sequence of a 13·5 kb DNA segment from the left arm of yeast chromosome XIV reveals MER1; RAP1; a new putative member of the DNA replication complex and a new putative serine/threonine phosphatase gene

Françoise Coster; L Van Dyck; Jean-Luc Jonniaux; Bénédicte Purnelle; André Goffeau


Yeast | 1995

An 8.2 kb DNA segment from chromosome XIV carries the RPD3 and PAS8 genes as well as the Saccharomyces cerevisiae homologue of the thiamine-repressed nmt1 gene and a chromosome III-duplicated gene for a putative aryl-alcohol dehydrogenase.

L Van Dyck; A Pascual-Ahuir; Bénédicte Purnelle; André Goffeau

Collaboration


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André Goffeau

Université catholique de Louvain

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Bénédicte Purnelle

Université catholique de Louvain

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J. Skala

Université catholique de Louvain

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H Tettelin

Université catholique de Louvain

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Jean-Luc Jonniaux

Université catholique de Louvain

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A Pascual-Ahuir

Université catholique de Louvain

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Bruno André

Université libre de Bruxelles

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Elisabetta Balzi

Université catholique de Louvain

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Evelyne Dubois

Université libre de Bruxelles

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Françoise Coster

Université catholique de Louvain

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