L Van Dyck
Université catholique de Louvain
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Featured researches published by L Van Dyck.
The EMBO Journal | 1994
H. Feldmann; Michel Aigle; G. Aljinovic; Bruno André; M.C. Baclet; C. Barthe; Axel Baur; Bécam Am; N. Biteau; Eckhard Boles; T. Brandt; M. Brendel; M. Brueckner; F. Bussereau; C. Christiansen; R. Contreras; M. Crouzet; C. Cziepluch; N. Demolis; T. Delaveau; F. Doignon; H. Domdey; S. Duesterhus; Evelyne Dubois; Bernard Dujon; M. El Bakkoury; K.-D. Entian; M. Feuermann; W. Fiers; G.M. Fobo
In the framework of the EU genome‐sequencing programmes, the complete DNA sequence of the yeast Saccharomyces cerevisiae chromosome II (807 188 bp) has been determined. At present, this is the largest eukaryotic chromosome entirely sequenced. A total of 410 open reading frames (ORFs) were identified, covering 72% of the sequence. Similarity searches revealed that 124 ORFs (30%) correspond to genes of known function, 51 ORFs (12.5%) appear to be homologues of genes whose functions are known, 52 others (12.5%) have homologues the functions of which are not well defined and another 33 of the novel putative genes (8%) exhibit a degree of similarity which is insufficient to confidently assign function. Of the genes on chromosome II, 37‐45% are thus of unpredicted function. Among the novel putative genes, we found several that are related to genes that perform differentiated functions in multicellular organisms of are involved in malignancy. In addition to a compact arrangement of potential protein coding sequences, the analysis of this chromosome confirmed general chromosome patterns but also revealed particular novel features of chromosomal organization. Alternating regional variations in average base composition correlate with variations in local gene density along chromosome II, as observed in chromosomes XI and III. We propose that functional ARS elements are preferably located in the AT‐rich regions that have a spacing of approximately 110 kb. Similarly, the 13 tRNA genes and the three Ty elements of chromosome II are found in AT‐rich regions. In chromosome II, the distribution of coding sequences between the two strands is biased, with a ratio of 1.3:1. An interesting aspect regarding the evolution of the eukaryotic genome is the finding that chromosome II has a high degree of internal genetic redundancy, amounting to 16% of the coding capacity.
Yeast | 1997
L Van Dyck; H Tettelin; Bénédicte Purnelle; André Goffeau
An 18·3 kb DNA segment from yeast Saccharomyces cerevisiae chromosome VII encompasses the previously characterized MEP1, NUP57 and PPT1 genes as well as seven new open reading frames (ORFs) of at least 100 residues. G6358 is an ubiquitous glutamine‐dependant asparagine synthase. G6362 is a membrane protein highly homologous to a protein of unknown function in the yeast Schizosaccharomyces pombe. Three ORFs (G6324, G6335 and G6365) have no significant homology with previously reported proteins or characteristic motifs. G6321 and G6359, enclosed in longer ORFs, are not likely to be coding. The segment also contains tRNA genes for Asn, Arg and Ile as well as a sigma element and two solo deltas. ORFs and genetic elements are named according to a preliminary working nomenclature. The sequence is recorded in GenBankTM/EMBL under Accession Number X83099.©1997 John Wiley & Sons, Ltd.
Journal of Biological Chemistry | 1994
Elisabetta Balzi; M Wang; Serge Leterme; L Van Dyck; André Goffeau
Journal of Biological Chemistry | 1994
L Van Dyck; D A Pearce; F Sherman
Yeast | 1992
L Van Dyck; Bénédicte Purnelle; J. Skala; André Goffeau
Yeast | 1992
Bénédicte Purnelle; J. Skala; L Van Dyck; André Goffeau
Yeast | 1994
L Van Dyck; Jean-Luc Jonniaux; T de Melo Barreiros; K Kleine; André Goffeau
Yeast | 1992
J. Skala; L Van Dyck; Bénédicte Purnelle; André Goffeau
Yeast | 1995
Françoise Coster; L Van Dyck; Jean-Luc Jonniaux; Bénédicte Purnelle; André Goffeau
Yeast | 1995
L Van Dyck; A Pascual-Ahuir; Bénédicte Purnelle; André Goffeau