L. Yasemin Koç
Ankara University
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Featured researches published by L. Yasemin Koç.
European Journal of Medicinal Chemistry | 2013
Hüseyin Akbaş; Aytuğ Okumuş; Zeynel Kılıç; Tuncer Hökelek; Yasemin Süzen; L. Yasemin Koç; Leyla Açık; Z. Betül Çelik
A number of partly (7-9) and fully (10a-12d, Scheme 1) substituted mono(4-fluorobenzyl)spiro cyclotriphosphazenes was prepared. The structures of the compounds were determined by MS, FTIR, 1D and 2D NMR techniques. The crystal structures of 9, 11b and 12b were verified by X-ray diffraction analysis. In vitro cytotoxic activity of the phosphazenes (10a-12d) against HeLa cervical cancer cell lines was evaluated. Compound 12c was found to be the most effective, as it is a cytotoxic reagent that might activate apoptosis by altering mitochondrial membrane potential. Compounds 10b, 11b and 12b showed very good activity against yeast strains Candida tropicalis and Candida albicans. BamHI and HindIII digestion results demonstrate that the compounds (10a-12a, 10b-12b, 10d-12d), and (9, 10c-12c) bind with G/G and A/A nucleotides, respectively.
Phosphorus Sulfur and Silicon and The Related Elements | 2013
Nuran Asmafiliz; Zeynel Kılıç; Aslı Öztürk; Yasemin Süzen; Tuncer Hökelek; Leyla Açık; Z. Betül Çelik; L. Yasemin Koç; Mehmet Lütfi Yola; Zafer Üstündağ
Abstract The condensation reactions of hexachlorocyclotriphosphazene (N3P3Cl6) with mono (1 and 2) and bisferrocenyldiamines (3–5 and 7) resulted in the formation of tetrachloro mono- (8 and 9) and bisferrocenylspirocyclotriphosphazenes (10–13). In addition the tetramorpholino mono- (8a and 9a) and bisferrocenylphosphazenes (10a–12a) were obtained from the reactions of the corresponding tetrachlorophosphazenes (8–12) with excess morpholine. The structures of all the phosphazenes were determined using FTIR, MS, 1H, 13C, and 31P NMR and 2-dimensional NMR techniques. The structures of 9a and 13 were determined by single crystal X-ray diffraction techniques. Cyclic voltammetric investigations of compounds 8a, 9a, and 11a revealed that ferrocene redox centers undergo reversible oxidation. These ferrocenylphosphazenes appear to be quite robust electrochemically. Interactions between the compounds 8a, 9a, 11a, and 12a and pBR322 plasmid DNA were investigated by agarose gel electrophoresis. [Supplementary materials are available for this article. Go to the publishers online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional text and figures.] GRAPHICAL ABSTRACT
Journal of Thermal Analysis and Calorimetry | 2016
Hüseyin Akbaş; Aytuğ Okumuş; Ahmet Karadağ; Zeynel Kılıç; Tuncer Hökelek; L. Yasemin Koç; Leyla Açık; Betül Aydın; Mustafa Türk
Inorganic Chemistry | 2009
Nuran Asmafiliz; Zeynel Kılıç; Aslı Öztürk; Tuncer Hökelek; L. Yasemin Koç; Leyla Açık; Ozgul Kisa; Ali Albay; Zafer Üstündağ; Ali Osman Solak
Journal of Molecular Structure | 2013
Yasemin Tümer; Nuran Asmafiliz; Zeynel Kılıç; Tuncer Hökelek; L. Yasemin Koç; Leyla Açık; Mehmet Lütfi Yola; Ali Osman Solak; Yağmur Öner; Devrim Dundar; Makbule Yavuz
Inorganic Chemistry | 2012
Gamze Elmas; Aytuğ Okumuş; Zeynel Kılıç; Tuncer Hökelek; Leyla Açık; Hakan Dal; Nagehan Ramazanoğlu; L. Yasemin Koç
Polyhedron | 2011
Aytuğ Okumuş; Zeynel Kılıç; Tuncer Hökelek; Hakan Dal; Leyla Açık; Yağmur Öner; L. Yasemin Koç
European Journal of Medicinal Chemistry | 2014
Gamze Elmas; Aytuğ Okumuş; L. Yasemin Koç; Hossien Soltanzade; Zeynel Kılıç; Tuncer Hökelek; Hakan Dal; Leyla Açık; Zafer Üstündağ; Devrim Dundar; Makbule Yavuz
Journal of Biological Inorganic Chemistry | 2015
Yasemin Tümer; L. Yasemin Koç; Nuran Asmafiliz; Zeynel Kılıç; Tuncer Hökelek; Hossien Soltanzade; Leyla Açık; Mehmet Lütfi Yola; Ali Osman Solak
Inorganica Chimica Acta | 2015
Gürcü Mutlu; Gamze Elmas; Zeynel Kılıç; Tuncer Hökelek; L. Yasemin Koç; Mustafa Türk; Leyla Açık; Betül Aydın; Hakan Dal