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Featured researches published by Laetitia Nyirazinyoye.


JAMA Pediatrics | 2008

Depressive Symptoms in Youth Heads of Household in Rwanda Correlates and Implications for Intervention

Neil W. Boris; Lisanne A. Brown; Tonya R. Thurman; Janet C. Rice; Leslie M. Snider; Joseph Ntaganira; Laetitia Nyirazinyoye

OBJECTIVE To examine the level of depressive symptoms and their predictors in youth from one region of Rwanda who function as heads of household (ie, those responsible for caring for other children) and care for younger orphans. DESIGN Cross-sectional survey SETTING Four adjoining districts in Gigonkoro, an impoverished rural province in southwestern Rwanda. PARTICIPANTS Trained interviewers met with the eldest member of each household (n = 539) in which a youth 24 years old or younger was caring for 1 child or more. MAIN EXPOSURE Serving as a youth head of household. MAIN OUTCOME MEASURES Rates and severity of depressive symptoms using the Center for Epidemiologic Studies Depression scale; measures of grief, adult support, social marginalization, and sociodemographic factors using scales developed for this study. RESULTS Of the 539 youth heads of household, 77% were subsistence farmers and only 7% had attended school for 6 years or more. Almost half (44%) reported eating only 1 meal a day in the last week, and 80% rated their health as fair or poor. The mean score on the Center for Epidemiologic Studies Depression scale was 24.4, exceeding the most conservative published cutoff score for adolescents. Multivariate analysis revealed that reports of depressive symptoms that exceeded the clinical cutoff were associated with having 3 basic household assets or fewer, such as a mattress and a spare set of clothes (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.06-2.70), eating less than 1 meal per day (OR, 1.68; 95% CI, 1.09-2.60), reporting fair health (OR, 1.32; 95% CI, 0.76-2.29) or poor health (OR, 2.33; 95% CI, 1.17-4.64), endorsing high levels of grief (OR, 2.67; 95% CI, 1.73-4.13), having at least 1 parent die in the genocide as opposed to all other causes of parental death (OR, 1.83; 95% CI, 1.10-3.04), and not having a close friend (OR, 1.91; 95% CI, 1.17-3.12). There was an interaction between marginalization from the community and alcohol use; youth who were highly marginalized and did not drink alcohol were more than 3 times more likely to report symptoms of depression (OR, 3.07; 95% CI, 1.73-5.42). When models were constructed by grouping theoretically related variables into blocks and controlling for other blocks, the emotional status block of variables (grief and marginalization) accounted for the most variance in depressive symptoms. CONCLUSIONS Orphaned youth who head households in rural Rwanda face many challenges and report high rates of depressive symptoms. Interventions designed to go beyond improving food security and increasing household assets may be needed to reduce social isolation of youth heads of household. The effect of head-of-household depressive symptoms on other children living in youth-headed households is unknown.


The Journal of Infectious Diseases | 2014

The Impact of Polio Eradication on Routine Immunization and Primary Health Care: A Mixed-Methods Study

Svea Closser; Kelly Cox; Thomas Parris; R. Matthew Landis; Judith Justice; Ranjani Gopinath; Kenneth Maes; Hailom Banteyerga Amaha; Ismaila Zango Mohammed; Aminu Mohammed Dukku; Patricia Omidian; Emma Varley; Pauley Tedoff; Adam D. Koon; Laetitia Nyirazinyoye; Matthew A. Luck; W. Frank Pont; Vanessa Neergheen; Anat Rosenthal; Peter Nsubuga; Naveen Thacker; Rashid Jooma; Elizabeth Nuttall

Background. After 2 decades of focused efforts to eradicate polio, the impact of eradication activities on health systems continues to be controversial. This study evaluated the impact of polio eradication activities on routine immunization (RI) and primary healthcare (PHC). Methods. Quantitative analysis assessed the effects of polio eradication campaigns on RI and maternal healthcare coverage. A systematic qualitative analysis in 7 countries in South Asia and sub-Saharan Africa assessed impacts of polio eradication activities on key health system functions, using data from interviews, participant observation, and document review. Results. Our quantitative analysis did not find compelling evidence of widespread and significant effects of polio eradication campaigns, either positive or negative, on measures of RI and maternal healthcare. Our qualitative analysis revealed context-specific positive impacts of polio eradication activities in many of our case studies, particularly disease surveillance and cold chain strengthening. These impacts were dependent on the initiative of policy makers. Negative impacts, including service interruption and public dissatisfaction, were observed primarily in districts with many campaigns per year. Conclusions. Polio eradication activities can provide support for RI and PHC, but many opportunities to do so remain missed. Increased commitment to scaling up best practices could lead to significant positive impacts.


BMC Health Services Research | 2014

Clinical mentorship to improve pediatric quality of care at the health centers in rural Rwanda: a qualitative study of perceptions and acceptability of health care workers

Anatole Manzi; Hema Magge; Bethany L. Hedt-Gauthier; Annie Michaelis; Felix Rwabukwisi Cyamatare; Laetitia Nyirazinyoye; Lisa R. Hirschhorn; Joseph Ntaganira

BackgroundDespite evidence supporting Integrated Management of Childhood Illness (IMCI) as a strategy to improve pediatric care in countries with high child mortality, its implementation faces challenges related to lack of or poor post-didactic training supervision and gaps in necessary supporting systems. These constraints lead to health care workers’ inability to consistently translate IMCI knowledge and skills into practice. A program providing mentoring and enhanced supervision at health centers (MESH), focusing on clinical and systems improvement was implemented in rural Rwanda as a strategy to address these issues, with the ultimate goal of improving the quality of pediatric care at rural health centers. We explored perceptions of MESH from the perspective of IMCI clinical mentors, mentees, and district clinical leadership.MethodsWe conducted focus group discussions with 40 health care workers from 21 MESH-supported health centers. Two FGDs in each district were carried out, including one for nurses and one for director of health centers. District medical directors and clinical mentors had individual in-depth interviews. We performed a hermeneutic analysis using Atlas.ti v5.2.ResultsStudy participants highlighted program components in five key areas that contributed to acceptability and impact, including: 1) Interactive, collaborative capacity-building, 2) active listening and relationships, 3) supporting not policing, 4) systems improvement, and 5) real-time feedback. Staff turn-over, stock-outs, and other facility/systems gaps were identified as barriers to MESH and IMCI implementation.ConclusionHealth care workers reported high acceptance and positive perceptions of the MESH model as an effective strategy to build their capacity, bridge the gap between knowledge and practice in pediatric care, and address facility and systems issues. This approach also improved relationships between the district supervisory team and health center-based care providers. Despite some challenges, many perceived a strong benefit on clinical performance and outcomes. This study can inform program implementers and policy makers of key components needed for developing similar health facility-based mentorship interventions and potential barriers and resistance which can be proactively addressed to ensure success.


Vulnerable Children and Youth Studies | 2009

Impact of a mentoring program on psychosocial wellbeing of youth in Rwanda: Results of a quasi-experimental study

Lisanne Brown; Tonya R. Thurman; Janet C. Rice; Neil W. Boris; Joseph Ntaganira; Laetitia Nyirazinyoye; Jean De Dieu; Leslie Snider

Addressing the psychosocial needs of vulnerable children and youth is viewed increasingly as a priority of humanitarian programs, particularly in Africa, where the scale of the problem necessitates community-based solutions. This quasi-experimental study tested a model of adult mentorship and support to improve psychosocial outcomes among youth-headed households in a rural area of Rwanda. Two rounds of data were collected from youth who served as heads of their households. Following the baseline survey in 2004 (n = 692), an adult mentorship program was implemented among half the sample. A follow-up survey was conducted after 18 months of intervention exposure (n = 593). Through regular home visits, mentors developed a stable, caring relationship with youth in their community living without an adult caregiver. Each mentor was assigned 2–3 youth-headed households located within their own community to visit at least once a month for 2–3 hours in the home. Over an 18-month period, 156 trained adult mentors (60% male, 40% female) visited and supported 441 households. Multivariable analyses explored linkages between exposure to the intervention and four key psychosocial outcomes: perceptions of adult support, marginalization, grief and symptoms of depression. Over time, youth with a mentor reported a significant increase in perceptions of available adult support and decreases in marginalization. While grief in the comparison group grew significantly over time, grief levels in the intervention group remained stable, suggesting that the mentorship program may have mitigated grief among youth in the intervention areas. Intervention respondents also reported a slight, but significant, decrease in depressive symptoms. Findings suggest that the mentoring program enhanced available support and community connectedness among youth in this study. However, program impact on emotional wellbeing was more modest. More intensive interventions may be needed to reduce grief symptoms and for those with high levels of depressive symptoms.


Medical Anthropology Quarterly | 2016

The Global Context of Vaccine Refusal: Insights from a Systematic Comparative Ethnography of the Global Polio Eradication Initiative.

Svea Closser; Anat Rosenthal; Kenneth Maes; Judith Justice; Kelly Cox; Patricia Omidian; Ismaila Zango Mohammed; Aminu Mohammed Dukku; Adam D. Koon; Laetitia Nyirazinyoye

Many of medical anthropologys most pressing research questions require an understanding how infections, money, and ideas move around the globe. The Global Polio Eradication Initiative (GPEI) is a


Trials | 2017

Can an educational podcast improve the ability of parents of primary school children to assess the reliability of claims made about the benefits and harms of treatments: study protocol for a randomised controlled trial

Daniel Semakula; Allen Nsangi; Matthew Prescott Oxman; Astrid Austvoll-Dahlgren; Sarah Rosenbaum; Margaret Kaseje; Laetitia Nyirazinyoye; Atle Fretheim; Iain Chalmers; Andrew D Oxman; Nelson Sewankambo

9 billion project that has delivered 20 billion doses of oral polio vaccine in campaigns across the world. With its array of global activities, it cannot be comprehensively explored by the traditional anthropological method of research at one field site. This article describes an ethnographic study of the GPEI, a collaborative effort between researchers at eight sites in seven countries. We developed a methodology grounded in nuanced understandings of local context but structured to allow analysis of global trends. Here, we examine polio vaccine acceptance and refusal to understand how global phenomena-in this case, policy decisions by donors and global health organizations to support vaccination campaigns rather than building health systems-shape local behavior.


Risk Management and Healthcare Policy | 2014

Effect of shortened Integrated Management of Childhood Illness training on classification and treatment of under-five children seeking care in Rwanda

Jean-Modeste Harerimana; Laetitia Nyirazinyoye; Jean-Bosco Ahoranayezu; Ferdinand Bikorimana; Bethany L. Hedt-Gauthier; Katherine A. Muldoon; Edward J Mills; Joseph Ntaganira

BackgroundClaims made about the effects of treatments are very common in the media and in the population more generally. The ability of individuals to understand and assess such claims can affect their decisions and health outcomes. Many people in both low- and high-income countries have inadequate aptitude to assess information about the effects of treatments. As part of the Informed Healthcare Choices project, we have prepared a series of podcast episodes to help improve people’s ability to assess claims made about treatment effects. We will evaluate the effect of the Informed Healthcare Choices podcast on people’s ability to assess claims made about the benefits and harms of treatments. Our study population will be parents of primary school children in schools with limited educational and financial resources in Uganda.MethodsThis will be a two-arm, parallel-group, individual-randomised trial. We will randomly allocate consenting participants who meet the inclusion criteria for the trial to either listen to nine episodes of the Informed Healthcare Choices podcast (intervention) or to listen to nine typical public service announcements about health issues (control). Each podcast includes a story about a treatment claim, a message about one key concept that we believe is important for people to be able to understand to assess treatment claims, an explanation of how that concept applies to the claim, and a second example illustrating the concept.We designed the Claim Evaluation Tools to measure people’s ability to apply key concepts related to assessing claims made about the effects of treatments and making informed health care choices. The Claim Evaluation Tools that we will use include multiple-choice questions addressing each of the nine concepts covered by the podcast. Using the Claim Evaluation Tools, we will measure two primary outcomes: (1) the proportion that ‘pass’, based on an absolute standard and (2) the average score.DiscussionAs far as we are aware this is the first randomised trial to assess the use of mass media to promote understanding of the key concepts needed to judge claims made about the effects of treatments.Trial registrationPan African Clinical Trials Registry, PACTR201606001676150. Registered on 12 June 2016. http://www.pactr.org/ATMWeb/appmanager/atm/atmregistry?dar=true&tNo=PACTR201606001676150.


African Journal of Primary Health Care & Family Medicine | 2018

‘He should feel your pain’: Patient insights on patient–provider communication in Rwanda

Vincent Kalumire Cubaka; Michael Schriver; Janvier B. Kayitare; Phil Cotton; Helle Terkildsen Maindal; Laetitia Nyirazinyoye; Per Kallestrup

Background Integrated Management of Childhood Illness (IMCI) is an effective 11-day standard training; however, due to budgetary expenses and human resource constraints, many health professionals cannot take 11 days off work. As a result, shortened training curriculums (6-day) have been proposed. We used a cross-sectional study to evaluate the effect of this shortened training on appropriate IMCI classification and treatment of under-five childhood illness management in Rwanda. Methods A cross-sectional study was conducted in 22 health centers in Rwanda, comparing data from 121 nurses, where 55 nurses completed the 11-day and 66 nurses completed the 6-day training. Among 768 children, we evaluated clinical outcomes from May 2011 to April 2012. Descriptive statistics were used to display the sociodemographic characteristics of health providers; including level of education, sex, age, and professional experiences. Bivariable and multivariable analyses were used to test for differences between nurses in the 6-day versus 11-day training on the appropriate classification and treatment of childhood illness. Results Our findings show that at the bivariable level and after controlling for confounders in the multivariable analysis, the only significant differences detected between nurses in the long and short training was the classification of fever (adjusted odds ratio [aOR] 0.7, 95% confidence interval [CI] 0.64–0.75) and treatment of pneumonia (aOR 0.8, 95% CI 0.70–0.89). Nurses in the short training had lower odds of inappropriate misclassification and treatment for these two conditions. Conclusion There was no difference in classification and treatment of childhood illness among nurses who completed the standard and short IMCI training courses. Short-training could be a more cost-saving option for health facilities without compromising the key outcomes related to case management.


Tropical Medicine & International Health | 2017

Exogenous factors matter when interpreting the results of an impact evaluation: A case study of rainfall and child health program intervention in Rwanda

Assumpta Mukabutera; Dana R. Thomson; Bethany L. Hedt-Gauthier; Sidney Atwood; Paulin Basinga; Laetitia Nyirazinyoye; Kevin P. Savage; Marcellin Habimana; Megan Murray

Background Patient–provider communication is an interpersonal interaction between a patient and a health care provider. Objective This study explored patients’ communication preferences and perceptions on what factors influence the patient–provider communication in primary health care settings in Rwanda. Methods In-depth semi-structured interviews with 15 individuals including 8 with limited literacy. A thematic inductive analysis was used. Results Patients valued communication with providers and expressed the need for interacting with caring, empathic providers who can share all the information they want and involve them in their own care. Health literacy and power issues were factors that may influence patient–provider communication. Patients with limited literacy appeared to rely highly on health care providers for making decisions about and managing their health care. Conclusion The expressed preferences, including those of patients with limited literacy, aligned well with the patient-centred care model. There were indications of a power imbalance weighing on the provider’s side. Although patients with limited literacy were reliant on providers for decision-making, they were ready to be more involved in the care, suggesting a potential for improved patient involvement even for patients with paternalistic care preferences. These patients’ insights can impact policies and curricula to optimise clinical practice. Generated knowledge will contribute to the indispensable yet underdeveloped field of health communication in sub-Saharan Africa. Practice implications Findings call for more inclusion of patient perspectives in the patient–provider encounter. This could require more training of professionals and research on the topic, both in Rwanda and in other regions.


American Journal of Public Health | 2017

Per Diems in Polio Eradication: Perspectives From Community Health Workers and Officials

Svea Closser; Anat Rosenthal; Judith Justice; Kenneth Maes; Marium Sultan; Sarah Banerji; Hailom Banteyerga Amaha; Ranjani Gopinath; Patricia Omidian; Laetitia Nyirazinyoye

Public health interventions are often implemented at large scale, and their evaluation seems to be difficult because they are usually multiple and their pathways to effect are complex and subject to modification by contextual factors. We assessed whether controlling for rainfall‐related variables altered estimates of the efficacy of a health programme in rural Rwanda and have a quantifiable effect on an intervention evaluation outcomes.

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Joseph Ntaganira

National University of Rwanda

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Assumpta Mukabutera

National University of Rwanda

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Hema Magge

Brigham and Women's Hospital

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Judith Justice

University of California

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Kenneth Maes

Oregon State University

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