Lajos Kocsis

Endometrial adenocarcinoma with coexisting adenomatoid tumor of the uterus

BACKGROUND Uterine adenomatoid tumors may be present in up to 1% of hysterectomy specimens, and their infiltrative pattern may simulate that of adenocarcinomas. CASE This is a report on the coexistence of a uterine adenomatoid tumor and an endometrial adenocarcinoma, both chance findings in a 41-year-old woman undergoing hysterectomy because of a preoperative diagnosis of metrorrhagia due to leiomyomas. CONCLUSION Although uterine adenomatoid tumors are believed to be rare, they may pose a differential diagnostic problem in the pathologic staging of endometrial carcinomas, because they form gland-like lumina and infiltrate the myometrium. To our knowledge, no previous coexistence of these two tumors has been reported.

Treatment of oily wastewater by combining ozonation and microfiltration

AbstractIn process industries, a large amount of wastewater is generated in the form of oil-in-water emulsions, which cannot be treated effectively using traditional physical methods. The aim of our investigation was to examine the applicability of the membrane technique and the effect of pre-ozonation in oily wastewater treatment. Pre-ozonation followed by microfiltration (MF) was investigated to determine the main effects of ozonation on the oily water and the filtration parameters such as permeate flux, organic content retention and membrane fouling. Experiments were carried out with a laboratory-scale batch-stirred filtration device, using polyethersulphone MF membranes with a pore size 0.2 μm. The model oily wastewater that was used in these experiments contained petroleum. The results demonstrated that the chemical oxygen demand could be eliminated more effectively through the combination of ozone pre-treatment and membrane filtration, compared to membrane filtration alone.

The case of the purple colon

Purple discoloration of the large bowel at autopsy was related to beetroot ingestion and post-mortem changes.

Expression of growth hormone-releasing hormone receptors in apocrine adnexal tumours and apocrine glands of the skin

Encouraged by our previous finding of growth hormone-releasing hormone receptor (GHRH-R) expression in metaplastic and neoplastic apocrine breast epithelium, we examined a small series of skin adnexal tumours with various degrees of apocrine (oxyphilic) differentiation, as well as normal axillary and anogenital apocrine sweat glands, for the expression of GHRH-R. Sections of formalin-fixed paraffin-embedded tissue blocks were immunostained for gross cystic disease fluid protein-15 (GCDFP-15) and androgen receptor (AR), to prove apocrine differentiation and correlate it with areas of GHRH-R expression. All but one of 19 tumours with apocrine epithelium and all five benign apocrine glands stained with both anti-GHRH-R antibodies used, each labelling a different domain of the receptor. Non-apocrine areas of the tumours and four eccrine tumours without oxyphilic features did not stain, but most sebaceous glands and some eccrine glands were labelled. Our data suggest that anti-GHRH-R antibodies highlight apocrine differentiation at extramammary sites also. Although GHRH-R seems to have a sensitivity comparable to classic apocrine markers such as AR and GCDFP-15, it seems to be inferior in specificity. The GHRH-R labelling of apocrine glands and neoplastic epithelium might also interfere with the emerging anti-GHRH targeted treatment of some malignancies acting on these receptors.

Elastic staining does not assist detection of venous invasion in cutaneous melanoma

The aim of the present study was to determine the benefit of orcein elastic staining of primary cutaneous melanoma specimens in detecting venous invasion. Primary cutaneous melanomas in vertical growth phase were assessed for vascular invasion. All tumour blocks were stained with haematoxylin and eosin (H&E) and orcein. The cases were reviewed by two pathologists. Vascular invasion was not identified more frequently on orcein stained slides than on H&E stained ones. Elastosis and periappendiceal elastic fibres interfered with vascular invasion detection with elastic staining. Based on our study, we conclude that elastic stains such as orcein do not improve the detection rate of venous invasion in primary cutaneous melanomas.

Incidentally Discovered Diffuse Large B-Cell Lymphoma Limited to the Endocervical Mucosa in a Young Female Patient

Primary high-grade non-Hodgkin lymphoma of the female genital tract is extremely rare. Vaginal bleeding, abdominal pain or urinary complaints might be its most frequent symptoms. We report a 27-year-old multipara who underwent large loop excision of the transformation zone because of the repeated finding of a low-grade squamous intraepithelial lesion identified during routine cancer screening. Incidentally, CD20-positive, primary, diffuse large B-cell lymphoma infiltrating the mucosa of the endocervix was also diagnosed from this specimen. The case is unusual because the patient had no symptoms, specific colposcopic signs or visible mass. R-CHOP 21 immunochemotherapy was introduced and resulted in complete remission without hysterectomy. The patient is without any evidence of disease after 49 months of follow-up. Primary cervical lymphomas are mainly subepithelial initially, and therefore they may be under-recognized due to the inefficiency of smears to diagnose such lesions. Early diagnosis and available targeted treatment allowed a cure in the reported example.