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Featured researches published by Lan Jia.


Colloids and Surfaces B: Biointerfaces | 2011

Polyamidoamine dendrimers surface-engineered with biomimetic phosphorylcholine as potential drug delivery carriers.

Lan Jia; Jian-Ping Xu; Hai Wang; Jian Ji

Biomimetic acryloyloxyethyl phosphorylcholine (APC) was used to react with generation 5 poly(amido amine) (PAMAM) dendrimers (G5) via the Michael addition reaction between primary amino group of PAMAM dendrimers and acrylic functional group of APC. FTIR and (1)H NMR confirmed the success of surface modification of G5. The primary amino and phosphorylcholine (PC) group numbers of the surface engineered PAMAM dendrimers (G5-PC) were calculated to be 56 and 50 via (1)H NMR and potentiometric titration. Cell viability and cell morphology studies indicated that biomimetic phosphorylcholine surface engineering successfully lowered the cytotoxicity of G5 PAMAM dendrimers. The hydrophobic interior of G5-PC was used to incorporate anti-cancer drug Adriamycin (ADR) and the G5-PC showed sustained releasing behavior for ADR. Cell morphology and viability tests indicated that the drug-loaded G5-PC conjugate could effectively enter the cancer cells and inhibit the growth of cancer cells. Biomimetic phosphorylcholine surface engineered PAMAM dendrimers with lowered cytotoxicity and high cellular penetrating ability showed great potential for the biomedical applications as nanocarrier system.


Analyst | 2010

Highly soluble PEGylated pyrene–gold nanoparticles dyads for sensitive turn-on fluorescent detection of biothiols

Jian-Ping Xu; Lan Jia; Yuan Fang; Li-Ping Lv; Zhe-Gang Song; Jian Ji

Highly soluble fluorescent pyrene derivative with substantially improved fluorescence intensity in aqueous buffer was obtained via PEGylation strategy. The highly soluble PEGylated pyrene (PEO-Py) non-covalently adsorbed onto the surface of gold nanoparticles (Au NPs) to form dyads with quenched fluorescence due to highly efficient energy transfer between PEO-Py and Au NPs. The PEO-Py/Au NPs dyads were used for the sensitive turn-on fluorescent detection of biothiols. The fluorescence of PEO-Py was restored by the addition of cysteine (Cys), indicating that Cys can modulate the energy transfer between PEO-Py and Au NPs. This phenomenon then allowed for the sensitive detection of Cys with a limit of detection (LOD) of 11.4 nM. The linear range of determination of Cys was from 1.25 x 10(-8) to 2.25 x 10(-7) M. None of the other amino acids found in proteins showed obvious interference with the determination. It was important to note that the detection sensitivity of the PEO-Py/Au NPs system was more than 5-fold improved compared with the Py/Au NPs system. In addition, other biothiol molecules, such as glutathione, could also be detected by this sensor system. The method was also successfully applied to the determination of the total content of aminothiols in human plasma. Therefore an easily prepared, inexpensive, high solubility fluorescent probe has been realized and is also expected to detect other biological analytes of interest.


Chemical Communications | 2010

Fluorescence detection of alkaline phosphatase activity with β-cyclodextrin-modified quantum dots

Lan Jia; Jian-Ping Xu; Di Li; Shaopeng Pang; Yuan Fang; Zhe-Gang Song; Jian Ji


Analyst | 2010

Label-free fluorescence detection of mercury(II) and glutathione based on Hg2+-DNA complexes stimulating aggregation-induced emission of a tetraphenylethene derivative

Jian-Ping Xu; Zhe-Gang Song; Yuan Fang; Ju Mei; Lan Jia; An Jun Qin; Jing Zhi Sun; Jian Ji; Ben Zhong Tang


Analyst | 2011

BSA–tetraphenylethene derivative conjugates with aggregation-induced emission properties: Fluorescent probes for label-free and homogeneous detection of protease and α1-antitrypsin

Jian-Ping Xu; Yuan Fang; Zhe-Gang Song; Ju Mei; Lan Jia; An Jun Qin; Jing Zhi Sun; Jian Ji; Ben Zhong Tang


Analyst | 2011

Aggregation-induced emission of tetraphenylethene derivative as a fluorescence method for probing the assembling/disassembling of amphiphilic molecules.

Congshan Zhu; Shaopeng Pang; Jian-Ping Xu; Lan Jia; Fangming Xu; Ju Mei; Anjun Qin; Jing Zhi Sun; Jian Ji; Ben Zhong Tang


Chinese Journal of Chemistry | 2014

Label-free Fluorescent Sensor for Probing Heparin-Protein Interaction Based on Supramolecular Assemblies

Lan Jia; Lingyun Xu; Zhaohui Wang; Jian-Ping Xu; Jian Ji


Journal of Nanoparticle Research | 2011

Phosphorylcholine functionalized dendrimers for the formation of highly stable and reactive gold nanoparticles and their glucose conjugation for biosensing

Lan Jia; Li-Ping Lv; Jian-Ping Xu; Jian Ji


Archive | 2010

Fluorescence probe for detecting thio-modified biomoleculesa, preparation and application methods thereof

Jian Ji; Lan Jia; Jian-Ping Xu


Archive | 2009

Anti-cancer medicine release system using cellular membrane biomimetic modification polyamide-amide as carrier and preparation method thereof

Jian Ji; Jian-Ping Xu; Lan Jia

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Ju Mei

Zhejiang University

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Ben Zhong Tang

Hong Kong University of Science and Technology

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