Larry A. Hoover
University of Kansas
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Publication
Featured researches published by Larry A. Hoover.
Laryngoscope | 2003
Anand K. Devaiah; Christopher G. Larsen; Ossama Tawfik; Paul O'Boynick; Larry A. Hoover
Objectives/Hypothesis The objective was to illustrate the use of endoscopic techniques as an evolving surgical modality in excision of esthesioneuroblastoma. The authors advocate this method with excision with anterior craniotomy for removal of cribriform plate or anterior cranial fossa tumor extension.
Laryngoscope | 2006
Luke O. Buchmann; Christopher G. Larsen; Ania Pollack; Ossama Tawfik; Kevin J. Sykes; Larry A. Hoover
Objective: The objective of this study was to examine the role of endoscopic approaches to the resection of anterior skull base and paranasal sinus malignancies at one tertiary care medical center.
Hearing Research | 1999
Joseph L. Edmonds; Larry A. Hoover; Dianne Durham
Removal of functional presynaptic input can result in a variety of changes in postsynaptic neurons in the central nervous system, including altered metabolism, changes in neuronal cell size, and even death of the postsynaptic cell. Age-dependent neuronal cell death and shrinkage has been documented in second order auditory neurons in the chick brainstem (nucleus magnocellularis, NM) following cochlea removal (Born and Rubel, 1985. J. Comp. Neurol. 231, 435-445). Here we examined whether the extent of neuronal cell death and shrinkage is also breed-dependent. We performed unilateral cochlea removal on both hatchling and adult birds of either a broiler breed (Arbor Acres Cross) or egg layer breed (Hy-Line, H and N) and killed birds one week later. Changes in neuronal cell number and cross sectional area were determined from Nissl-stained sections. We observed 25% neuronal cell loss and a 15-20% decrease in neuronal cross sectional area after cochlea removal in either broiler or egg layer hatchling birds. In adult birds, however, neuronal cell loss is breed-dependent. Adult egg layer birds lose an average of 37% of NM neurons after cochlea removal, while adult broiler birds show no cell loss. In both breeds of adult birds, cochlea removal results in a 20% decrease in neuronal cross sectional area. These results suggest that analysis of differences between breeds as well as ages of birds will prove fruitful in determining how afferent input controls neuronal survival and metabolism.
Laryngoscope | 1992
Yao S. Fu; Larry A. Hoover; Michael Franklin; Lorna Cheng; Mark H. Stoler
Presence of human papillomavirus (HPV) as the etiologic agent in nearly all upper respiratory tract recurrent papillomas is well‐established. The technique of nucleic acid hybridization now allows specific typing of HPV with a high degree of accuracy. This article reports a series of nine consecutive patients treated for nasal papillomas over the past 9 years. Eight of these patients had a personal history of genital papillomas (seven patients) or exposure (one patient). With the use of in situ hybridization and autoradiographic technique on paraffin‐embedded tissue sections, HPV RNA type 6/11 was expressed in eight of nine nasal papillomas, and corresponding HPV types were also found in the two cases with which concurrent anogenital papilloma tissue was also available for analysis. Human papillomavirus RNA types 16 and 18 were not detected in any of the specimens. Signals of HPV messenger RNA type 6/11 were stronger in the fungiform areas than in the inverted areas of papillomas.
Otolaryngology-Head and Neck Surgery | 1995
Gary Y. Shaw; Jeff Searl; Larry A. Hoover
Cricothyroid adduction increases tension to the vocal folds, thus increasing fundamental frequency and upper pitch range. We treated 10 patients with cricothyroid muscle dysfunction using this technique. Preoperative electromyographic, acoustic, and perceptual analysis was performed. Intraoperatively the effect of increasing tension on the fundamental, falsetto, and basal frequencies was measured by using a strain gauge to the adducting suture at several tensions and a cervical microphone connected to a pitch meter. Postoperative acoustic and perceptual analysis was then performed up to 18 months later. Analysis of pitch vs. tension curves indicates a near-linear relationship until very high tensions are applied. Statistically significant improvement was achieved in both acoustic and perceptual analysis, although some deterioration was noted between early and late results. Cricothyroid adduction is indicated for a large range of vocal fold tension problems.
Laryngoscope | 1999
Ann B. Robinson; Sanjoy K. Das; Daniel E. Bruegger; Larry A. Hoover; Thomas Sanford
Objectives: Demonstrate the induction of cyclooxygenase‐2 (COX‐2) in laryngeal papilloma. Discuss the possible causal role of COX‐2 in papilloma formation. Consider the potential for treatment of papilloma using selective COX‐2 inhibitors. Study Design: Molecular biological analysis of COX‐1 and COX‐2 in laryngeal papilloma. Methods: Tissue samples from five patients with recurrent respiratory papillomatosis (RRP) were analyzed by in situ hybridization, immunohistochemical staining, and reverse transcription polymerase chain reaction (RTPCR) techniques. Results: In situ hybridization to COX‐2 mRNA showed strong autoradiographic signal surrounding fibrovascular cores. COX‐1 autoradiographic signal was low intensity or nondetectable. Normal buccal mucosa biopsies showed low‐density or nondetectable autoradiographic signal for both COX‐1 and COX‐2 mRNAs. In situ hybridization results were corroborated by RT‐PCR studies. Levels of COX‐2 mRNA were 13‐fold more than those in normal mucosa. Immunohistochemical staining for COX‐1 and COX‐2 showed a similar pattern to that seen with in situ hybridization in both normal and papilloma tissues. Conclusions: There is an elevation of COX‐2 expression in papilloma tissues. This may represent a causal role of COX‐2 in the formation and proliferation of laryngeal papilloma. There may also be a role for selective COX‐2 inhibition for the treatment of RRP.
Laryngoscope | 2017
Naweed I. Chowdhury; Sameer Alvi; Kyle Kimura; Ossama Tawfik; Pradip Manna; D. David Beahm; Ann B. Robinson; Spencer Kerley; Larry A. Hoover
Human papilloma virus (HPV) infection has been shown to play an integral role in the development and prognosis of various head and neck cancers. Generational changes in sexual behavior may have led to an increased incidence of positivity in recent years. HPV positivity in both benign and malignant lesions of the sinonasal cavities has been shown in previous studies (estimates range from 20%–30% for malignancy). We intend to investigate if HPV positivity affected survival outcomes in our patient cohort.
Annals of Otology, Rhinology, and Laryngology | 1999
Matthew Glynn; Thomas Sanford; Larry A. Hoover; William Kinsey; Larry Dobbs; Daniel E. Bruegger
The role of human papillomavirus (HPV) in airway papillomas has been well defined in recent literature. The chronicity and recurrence of papillomas has been postulated to be a result of residual viral genome in tissue treated with standard laser techniques. Thirteen patients with airway papillomas were selected for study with polymerase chain reaction (PCR) methods to detect viral DNA. Specimens taken prior to laser therapy and specimens taken at laser margins were consistently positive for HPV DNA by PCR. The HPV DNA is apparently present in tissues after macroscopic disease has been ablated by laser techniques. Histologic analysis of laser biopsies demonstrated fragments of squamous epithelium with cytologic features of HPV infection. Laser treatment is ineffective in eradicating HPV-infected tissues from airway papillomas, and this finding supports the notion that recurrence is a product of HPV incorporated into tissue not ablated by laser irradiation. Specific methods, results, and clinical correlation will be discussed.
International Forum of Allergy & Rhinology | 2018
Vidur Bhalla; Adam McCann; Kevin J. Sykes; Larry A. Hoover; D. David Beahm; Alexander G. Chiu
Patients often have received some modality of head imaging prior to being evaluated for chronic sinonasal complaints, and the clinical significance of these scans on current sinonasal symptomatology is unknown.
International Forum of Allergy & Rhinology | 2017
Tran Le; Jacob New; Joel W. Jones; Shireen Usman; Sreeya Yalamanchali; Ossama Tawfik; Larry A. Hoover; Dan E. Bruegger; Sufi M. Thomas
Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor that presents in adolescent males. Although surgical excision is the mainstay of treatment, recurrences complicate treatment. There is a need to develop less invasive approaches for management. JNA tumors are composed of fibroblasts and vascular endothelial cells. We identified fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor (VEGF) expression in JNA‐derived fibroblasts. FGFR influences fibroblast proliferation and VEGF is necessary for angiogenesis. We hypothesized that targeting FGFR would mitigate JNA fibroblast proliferation, invasion, and migration, and that targeting the VEGF receptor would attenuate endothelial tubule formation.