Larry P. Tackett

Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae)

By means of bioassay-guided separation methods, the cancer cell growth inhibitory constituents residing in the bark, stem and leaves of the Mauritius medicinal plant Terminalia arjuna (Combretaceae) were examined. The cancer cell line active components were found to be gallic acid, ethyl gallate, and the flavone luteolin. Only gallic acid was previously known to occur in this plant. Luteolin has a well established record of inhibiting various cancer cell lines and may account for most of the rationale underlying the use of T. arjuna in traditional cancer treatments. Luteolin was also found to exhibit specific activity against the pathogenic bacterium Neisseria gonorrhoeae.

Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).

Bioassay-guided fractionation of extracts of various plants, marine organisms, and microorganisms has led to the discovery of new natural sources of a number of known compounds that have significant biological activity. The isolation of interesting and valuable cancer cell growth inhibitors including majusculamide C ( 1), axinastatin 5 ( 5), bengazoles A ( 6), B ( 7), and E ( 8), manzamine A ( 10), jaspamide ( 11), and neoechinulin A ( 19) has been summarized.

Isolation and structure of phakellistatin 2 from the eastern indian ocean marine sponge phakellia carteri

Abstract The marine sponge Phakellia carteri indigenous to the Republic of the Comoros was found to contain a new cell growth inhibitory (P388 cell line ED50 0.34 μg/ml) cyclo -heptapeptide named phakellistatin 2.

Isolation and X-ray crystal structure of racemic xestospongin D from the Singapore marine sponge Niphates SP1

Abstract (±)-Xestospongin D (2) has been isolated from the Singapore marine sponge Niphates sp . The natural product was found to be racemic in contrast to earlier isolations of (+)-xestospongin D from Xestospongia and Haliclona species. The (±)-xestospongin D was found to inhibit growth of certain human cancer cell lines comprising the NCI panel ( e.g. , leukemia subpanel, mean GI 50 3.62 ± 2.02 × 10 −6 M; breast subpanel, mean GI 50 4.53 ± 1.98 × 10 −6 M) as well as the murine P388 lymphocytic leukemia (ED 50 1.7 μg/mL) and the bacterium Micrococcus luteus .