Lars O. Hansson | Researchain

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Life Sciences | 1997

NEUROTRANSMITTER ABERRATIONS IN SCHIZOPHRENIA : NEW PERSPECTIVES AND THERAPEUTIC IMPLICATIONS

Arvid Carlsson; Lars O. Hansson; Nicholas Waters; Maria Carlsson

The dopamine hypothesis has dominated schizophrenia research for decades but is now yielding to a more diversified view, where the interaction of several neurotransmitters in complex circuitries is under scrutiny. Especially, glutamatergic and serotonergic mechanisms are attracting attention. However, the role of dopamine also needs further exploration and may still turn out to have novel therapeutic applications. In the present minireview an attempt is made to integrate preclinical and clinical data on neurotransmitter aberrations in schizophrenia and to discuss their therapeutic implications.

Archive | 1996

2-aminoindans as selective dopamine d3 ligands

Susanne R. Haadsma-Svensson; Bengt Ronny Andersson; Clas A. Sonesson; Chiu-Hong Lin; R. Nicholas Waters; Kjell Anders Ivan Svensson; Per Arvid Emil Carlsson; Lars O. Hansson; N. Peter Stjernlof

Archive | 1992

Centrally acting substituted phenylazacycloalkanes

Kjell Anders Ivan Svensson; Hakan Vilhelm Wikstrom; Per Arvid Emil Carlsson; Anna Maria Persdotter Boije; R. Nicholas Waters; Clas A. Sonesson; Nils Peter Stjernlof; Bengt Ronny Andersson; Lars O. Hansson

Journal of Medicinal Chemistry | 1995

On the quantitative structure-activity relationships of meta-substituted (S)-phenylpiperidines, a class of preferential dopamine D2 autoreceptor ligands : modeling of dopamine synthesis and release in vivo by means of partial least squares regression

Lars O. Hansson; Nicholas Waters; Susanna Holm; Clas Sonesson

Archive | 1994

Indoletetralins having dopaminergic activity

Bengt Ronny Andersson; Per Arvid Emil Carlsson; Lars O. Hansson; Clas A. Sonesson; N. Peter Stjernlof; Kjell Anders Ivan Svensson; R. Nicholas Waters; Susanne R. Haadsma-Svensson

Archive | 1992

Substituted (s)-3-phenylpiperidine derivatives, their preparation and their use as dopamine autoreceptor antagonists

Bengt Ronny Andersson; Anna Maria Persdotter Boije; Per Arvid Emil Carlsson; Lars O. Hansson; Clas A. Sonesson; Nils Peter Stjerulof; Kjell Anders Ivan Svensson; Ross Nicholas Waters; H kan Vilhem Wikström

Archive | 2001

Substituierte (s)-3-phenylpiperidin derivate, deren herstellung und deren verwendung als dopamin autorezeptor antagonisten

Bengt Ronny Andersson; Anna Maria Persdotter Boije; Per Arvid Emil Carlsson; Lars O. Hansson; Clas Sonesson; Nils Peter Stjerulof; Kjell Svensson; Ross Nicholas Waters; H»kan Wikström

Schizophrenia Research | 1997

Effects of antipsychotics on brain biochemistry in the normal and hypoglutamatergic state-identification of antipsychotic mechanisms: A multivariate approach

Nicholas Waters; Susanna Holm Waters; Lars O. Hansson; Maria Carlsson; Peter Martin; Arvid Carlsson

Schizophrenia Research | 1997

4. Neuropathology, biochemical79 - Biochemical heterogeneity in schizophrenia due to gender: A multivariate study of post-mortem brain biochemistry

Arvid Carlsson; Nicholas Waters; Susanna Holm Waters; Maria Carlsson; Carl-Gerhard Gottfries; Peter Martin; Lars O. Hansson

Archive | 1992

Substituted phenylazacycloalkanes as cns agents

Kjell Svensson; Håkan Wikström; Per Arvid Emil Carlsson; Anna Maria Persdotter Boije; Ross Nicholas Waters; Clas Sonesson; Nils Peter Stjerulof; Bengt Ronny Andersson; Lars O. Hansson

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