Lars Ole Goffeng
National Institute of Occupational Health
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Featured researches published by Lars Ole Goffeng.
Neurotoxicology and Teratology | 2008
Lars Ole Goffeng; Mona Skard Heier; Helge Kjuus; Hans Sjöholm; Kjell Aage Sørensen; Vidar Skaug
The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post exposure), with 49 tunnel workers with no history of exposure to acrylamide. Nerve conduction velocities (NCV), distal delay, F-response and amplitude in median and ulnar nerves of the right arm, peroneal, sural and tibial nerves of the right leg, visual evoked response (VER) and electroretinography (ERG) were measured. VER and ERG were also performed in 24 subjects more recently exposed to acrylamide grout (16 months post exposure). Exposure to acrylamide containing grouts was assessed by questionnaires. A statistically significant reduction in the mean sensory NCV of the sural nerve (p=0.005), as well as a non-significant reduction of sural amplitude was found in the previously exposed group compared to the control group. VER latencies to the onset of the occipital potential (N75) were prolonged in both exposed groups compared to the control group (p<0.05). ERG 30 Hz flicker amplitude was reduced in the recently exposed group compared to the referents (p<0.05). The results indicate slight subclinical, but persistent toxic effects in the sural nerve and the visual system in tunnel workers exposed to N-methylolacrylamide and acrylamide during grouting operations.
Scandinavian Journal of Work, Environment & Health | 2011
Lars Ole Goffeng; Monica Alvestrand; Bente Ulvestad; Kjell Aage Sørensen; Vidar Skaug; Helge Kjuus
OBJECTIVE The aim of this study was to examine possible exposure-related symptoms and neuropsychological changes among tunnel workers previously exposed to grout containing acrylamide and N-methylolacrylamide. METHODS In a cross sectional study, 44 male tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting operations were exam-in-ed with neuropsychological tests, 2-10 years after last exposure. The control group consisted of 49 male tunnel workers with no history of acrylamide exposure. Questionnaires were used to assess retrospectively recalled symptoms during work and current symptoms at the time of the examination. RESULTS The prevalence of paresthesia in hands and legs, and leg cramps during work peri-ods were higher in the exposed than control group. Self-reported prevalence of skin irritation, peeling of skin on the hands, white-finger attacks, headache, and breathlessness was also higher among the exposed workers. The Q-16 questionnaire on current symptoms indicated higher symptom prevalence among the exposed of impaired memory and concentration, emotional change, sleep disturbances, tiredness, headache, and sensory or motor changes. In contrast, no association was found between neuropsychological test results and acrylamide exposure, adjusting for relevant confounders. However, selected motor symptoms were associated with the corresponding results on tests for motor function. CONCLUSIONS Despite higher prevalences of self-reported current symptoms among the acrylamide-exposed compared to the control group, we did not find an association between occupational acrylamide exposure and health out-comes as measured by the chosen neuropsychological tests. Observed associations between chemical exposure and self-reported symptoms should be interpreted with great caution.
Industrial Health | 2017
Elisabeth M. Goffeng; Karl-Christian Nordby; Mika P. Tarvainen; Susanna Järvelin-Pasanen; Anthony Wagstaff; Lars Ole Goffeng; Merete Drevvatne Bugge; Øivind Skare; Jenny-Anne Sigstad Lie
The aim of this study was to investigate fluctuations in heart rate variability (HRV), which reflect autonomic nervous system (ANS) function and potential psychological and physical strain, among 24 health care workers during work and sleep during four consecutive extended work shifts. Data included 24/36/12 h of HRV measurements, two logbooks, and a questionnaire. A cross-shift/cross-week design was applied. HRV was measured during work, leisure time, and sleep. The HRV data included time-domain [mean RR, SD of normal to normal R-R intervals (SDNN), and root mean square of the successive differences (RMSSD)] and frequency-domain [low frequency (LF)/high frequency (HF) ratio] parameters. HRV parameters revealed significant differences among work, leisure time, and sleep. Mean RR, RMSSD, and SDNN values were lower and the LF/HF ratio was higher on the first versus last day of the work period; however, the differences were most prominent in the morning hours. The results indicate higher levels of cardiovascular stress on the first versus fourth day of the working period, and measurements at night indicate a satisfactory recovery from the extended shifts.
American Journal of Industrial Medicine | 1994
Rita Bast-Pettersen; Per Arne Drabløs; Lars Ole Goffeng; Yngvar Thomassen; Carl G. Torres
Scandinavian Journal of Work, Environment & Health | 2004
Helge Kjuus; Lars Ole Goffeng; Mona Skard Heier; Hans Sjöholm; Ovrebø S; Skaug; Paulsson B; Törnqvist M; Stein Brudal
Scandinavian Journal of Work, Environment & Health | 2005
Helge Kjuus; Inger-Lise Hansteen; Ryberg D; Lars Ole Goffeng; Ovrebø S; Skaug
Neurotoxicology | 2008
Lars Ole Goffeng; Helge Kjuus; Mona Skard Heier; Monica Alvestrand; Bente Ulvestad; Vidar Skaug
Scandinavian Journal of Work, Environment & Health | 2001
Knut Skulberg; Knut Skyberg; Wijnand Eduard; Lars Ole Goffeng; Arnt Inge Vistnes; Finn Levy; Helge Kjuus
Archive | 2002
Helge Kjuus; Lars Ole Goffeng; Mona Skard Heier; Steinar Øvrebø; Vidar Skaug; David Ryberg; Hans Sjöholm; Inger-Lise Hansteen; Margretha Törnqvist; Paulsson B; Bjørn T. Langeland; Stein Brudal; Ørn Terje Foss
44 | 2016
Kari Emilie Heldal; Lene Madsø; Elín Einarsdóttir Thornér; Lars Ole Goffeng; Karl-Christian Nordby; Åse Dalseth Austigard; Kristin Svendsen