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Dive into the research topics where Lars Schiøtt Sørensen is active.

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Featured researches published by Lars Schiøtt Sørensen.


Chemosphere | 2018

Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model

Marie Frederiksen; Heather M. Stapleton; Katrin Vorkamp; Thomas F. Webster; Niels Martin Jensen; Jens Ahm Sørensen; Flemming Nielsen; Lisbeth E. Knudsen; Lars Schiøtt Sørensen; Per Axel Clausen; Jesper Bo Nielsen

Organophosphate esters (OPEs) are used as flame retardants, plasticizers, and as hydraulic fluids. They are present in indoor environments in high concentrations compared with other flame retardants, and human exposure is ubiquitous. In this study we provide data for estimating dermal uptake for eight OPEs and ranking in OPEs risk assessment. Dermal uptake and percutaneous penetration of the OPEs were studied in a Franz diffusion cell system using human skin dosed with a mixture of OPEs in an ethanol:toluene (4:1) solution. Large variation in penetration profiles was observed between the OPEs. The chlorinated OPEs tris(2-chloroisopropyl) phosphate (TCIPP), and in particular tris(2-chloroethyl) phosphate (TCEP), penetrated the skin quite rapidly while tris(1,3-dichlor-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP) tended to build up in the skin tissue and only smaller amounts permeated through the skin. For tris(isobutyl) phosphate (TIBP), tris(n-butyl) phosphate (TNBP), and tris(methylphenyl) phosphate (TMPP) the mass balance was not stable over time indicating possible degradation during the experimental period of 72 h. The rates at which OPEs permeated through the skin decreased in the order TCEP > TCIPP ≥ TBOEP > TIBP ≥ TNBP > TDCIPP > TPHP > TMPP. Generally, the permeation coefficient, kp, decreased with increasing log Kow, whereas lag time and skin deposition increased with log Kow. The present data indicate that dermal uptake is a non-negligible human exposure pathway for the majority of the studied OPEs.


Journal of Structural Fire Engineering | 2017

Fire resistance of extruded hollow-core slabs

Kristian Dahl Hertz; Luisa Giuliani; Lars Schiøtt Sørensen

Purpose Prefabricated extruded hollow-core slabs are preferred building components for floor structures in several countries. It is therefore important to be able to document the fire resistance of these slabs proving fulfilment of standard fire resistance requirements of 60 and 120 min found in most national building regulations. The paper aims to present a detailed analysis of the mechanisms responsible for the loss of load-bearing capacity of hollow-core slabs when exposed to fire. Design/methodology/approach Furthermore, it compares theoretical calculation and assessment according to the structural codes with data derived from a standard fire test and from a thorough examination of the comprehensive test documentation available on fire exposed hollow-core slabs. Findings Mechanisms for loss of load-bearing capacity are clarified, and evidence of the fire resistance is found. Originality value For the first time, the mechanisms responsible for loss of load-bearing capacity are identified, and test results and calculation approach are for the first time applied in accordance with each other for assessment of fire resistance of the structure.


Journal of civil engineering and architecture | 2015

Sensitivity Analysis of a Simplified Fire Dynamic Model

Lars Schiøtt Sørensen; Anker Nielsen

This paper discusses a method for performing a sensitivity analysis of parameters used in a simplified fire model for temperature estimates in the upper smoke layer during a fire. The results from the sensitivity analysis can be used when individual parameters affecting fire safety are assessed. If the variation of a single parameter is found to have a major impact on fire safety, it may be necessary to conservatively select this parameter in order to incorporate additional safety. We compare fire scenarios in rooms surrounded by lightweight as well as heavy walls in order to investigate which parameters are the most significant in each case. We apply the Sobol method, which is a quantitative method that gives the percentage of the total output variance that each parameter accounts for. The most important parameter is found to be the energy release rate that explains 92% of the uncertainty in the calculated results for the period before thermal penetration (tP) has occurred. The analysis is also done for all combinations of two parameters in order to find the combination with the largest effect. The Sobol total for pairs had the highest value for the combination of energy release rate and area of opening, which explains 96% of the uncertainty. After thermal penetration, the energy release rate is still the most important parameter, but now only explains 49% of the variation. The second parameter is the thickness of the surface material, which explains 43%.


Fire Safety Journal | 2005

Test method for spalling of fire exposed concrete

Kristian Dahl Hertz; Lars Schiøtt Sørensen


Chemosphere | 2016

Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model

Marie Frederiksen; Katrin Vorkamp; Niels Martin Jensen; Jens Ahm Sørensen; Lisbeth E. Knudsen; Lars Schiøtt Sørensen; Thomas F. Webster; Jesper Bo Nielsen


Sustainability | 2010

Energy Renovation of Buildings Utilizing the U-value Meter, a New Heat Loss Measuring Device

Lars Schiøtt Sørensen


DIOXIN2014: 34th international Symposium on Halogenated Persistent Organic Pollutants | 2014

Human exposure to novel flame retardants - from materials to humans

Marie Frederiksen; Katrin Vorkamp; Jesper Bo Nielsen; Lars Schiøtt Sørensen; Thomas F. Webster; Marios Vazakas; Jens Ahm Sørensen; Lisbeth E. Knudsen


Sustainability | 2013

Heat Transmission Coefficient Measurements in Buildings Utilizing a Heat Loss Measuring Device

Lars Schiøtt Sørensen


Energy Procedia | 2017

Can crawl space temperature and moisture conditions be calculated with a whole-building hygrothermal simulation tool?

Lies Vanhoutteghem; Martin Morelli; Lars Schiøtt Sørensen


Archive | 2014

Fire-safety engineering and performance-based codes

Lars Schiøtt Sørensen

Collaboration


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Jesper Bo Nielsen

University of Southern Denmark

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Kristian Dahl Hertz

Technical University of Denmark

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Luisa Giuliani

Technical University of Denmark

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