László Csabay

Follow-up studies of newborn-babies with congenital ventriculomegaly

Abstract The authors present the results of their follow-up studies of data from the last four years on patients with congenital ventriculomegaly. Objective: To study the psychomotor and mental developmental outcome of neonates with congenital ventriculomegaly diagnosed prenatally. In addition, patients were also classified into subgroups with subgrouping based on the etiology and complications of congenital ventriculomegaly and on the absence of ventriculoperitoneal shunt placement, and the findings compared between the different subgroups. Methods: Level 3 fetal ultrasonography was used for the prenatal diagnosis of congenital ventriculomegaly in 30 infants. Using neurological examination and the modified Brunet-Lézine infant test performed postnatal follow-up of motor and sensory development and intelligence, respectively. Results: The results show thirteen symptomless, well-developing patients, ten moderately handicapped patients and seven severely handicapped patients. Newborns with isolated, moderate ventriculomegaly have the best outcome.

Assessment of uterine circulation in ectopic pregnancy by transvaginal color Doppler

OBJECTIVE The aim of our study was to determine the effect of abnormal implantation on uterine circulation and to evaluate whether the assessment of uterinal blood flow can provide additional information for the diagnosis of tubal pregnancies. METHODS Forty-nine patients with ectopic pregnancy were examined by transvaginal color Doppler immediately before surgery. Resistance and pulsatility indices of blood flow in the uterine and tubal arteries were measured. RESULTS The blood flow parameters of the uterine and tubal arteries did not change with gestational age. There was a significant increase in blood flow on the side with the tubal gestation. Differences between sides were higher in the tubal arteries than in the main uterine arteries and showed no dependence on gestational age. CONCLUSION The abnormal implantation and tubal trophoblast invasion in ectopic pregnancy (EP) can cause more marked blood flow changes in the adjacent supplying vessels than in the main uterine arteries.

Sonographic measurement of the fetal iliac angle in trisomy 21, 18 and 13

Objective: To determine whether iliac wing angle measurement in second trimester fetuses is a useful sonographic marker for the detection of trisomy 21, 18 and 13. Methods: During the period between September 1998 and September 2001, 406 fetal iliac angle measurements were performed in women in the second trimester of their pregnancies. The iliac angle measurements in fetuses with trisomy 21 (n = 25), trisomy 18 (n = 10) and trisomy 13 (n = 5) were compared with iliac angle measurement in fetuses with normal karyotypes (n = 333). Results: The mean iliac wing angle in the fetuses with trisomy 21 was 92.67 and 79.35° and 74° in fetuses with trisomy 18 and 13 (the mean iliac wing angle in the healthy fetuses was 70.09°). Conclusion: The proven larger iliac wing angle in neonates with Down’s syndrome can be demonstrated sonographically during the pregnancy, especially during the second trimester, and may be useful in prenatal screening of trisomy 21. The sonographic measurement of the fetal iliac angle cannot be used as a marker for trisomy 18 and 13. We have shown that fetuses with trisomy 18 and 13, on average, have iliac angles only a few degrees larger than healthy fetuses.

Maternal hyperandrogenism beginning from early pregnancy and progressing until delivery does not produce virilization of a female newborn

A 33-year-old primagravida with a history of polycystic ovary syndrome was referred because of symptoms of moderate hyperandrogenism. Serum hormone levels, measured regularly from the 7th week of pregnancy until delivery, showed very high increases of testosterone, androstenedione and estradiol. Ultrasound showed no evidence of adrenal or ovarian masses. She delivered a female newborn with normal female external genitalia. Umbilical cord hormone levels were normal, except for a modest increase of serum testosterone. After delivery the androgen levels of the mother returned to normal and the symptoms of hyperandrogenism were also slightly improved.

Unilateral triplet ectopic pregnancy after in vitro fertilization and embryo transfer

OBJECTIVE To present a case report of a unilateral triplet ectopic pregnancy (EP) conceived by IVF-embryo transfer. DESIGN Case report. SETTING University Hospital, Budapest, Hungary. PATIENT(S) A 26-year-old infertile woman with a history of right salpingectomy, hyperprolactinemia, and male factor infertility underwent IVF-embryo transfer of three embryos. Early transvaginal sonography revealed a triplet pregnancy in the left fallopian tube (two at interstitial and one at ampullary location). INTERVENTION(S) Multiple dose methotrexate (MTX) therapy was applied. MAIN OUTCOME MEASURE(S) Follow-up pelvic ultrasounds and laboratory testing confirmed fetal cardiac activity cessation and decreasing beta-hCG levels. RESULT(S) In spite of the decreasing beta-hCG levels the tubes diameter increased, the patients symptoms escalated, and finally, the level of hemoglobin and hematocrit decreased. Laparotomy was performed with the removal of the left tube and cornual part of the uterus. CONCLUSION(S) Our case represents a very rare condition, a unilateral triplet EP after IVF-embryo transfer-the first one ever reported in the literature. After IVF-embryo transfer early ultrasound examinations are important to identify EPs at an early stage when medical management can still be taken into consideration. Strict monitoring is necessary to identify the success of medical intervention or the need for surgery.

Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant.

Schizencephaly is a congenital migrational anomaly resulting in a cleft in the cerebral hemisphere. In polymycrogyria, which is also a migrational disorder, the gyri are numerous and small, with proliferation of secondary and tertiary sulci. Agenesis of corpus callosum (partial or complete) is a relatively frequent malformation that can be associated with migrational anomalies and other brain malformations (Whitaker, 1996).

P14.51: Case of exomphalos complicated with umbilical cord teratoma

Congenital teratomas of the umbilical cord are extremely rare. Only eleven case are known in the literature and two of those were associated with exomphalos. A 23-year old mother was performed a routine ultrasound examination in the 17 week of gestation. The ultrasonographic examination revealed a 49 × 25 mm midline sac adjacent to the anterior abdominal wall containing a solid and cystic mass. The parents asked for termination of pregnancy. The fetus weighed 131 g without the tumor. From 4 mm of the fetal end the cord contained a sac, measuring 5.5 × 6 × 6 cm, covered by transparent membranes. Fetal organs, small and large bowels with appendix, and the spleen were herniated into the exomphalos, as well as a solid and cystic tumor mass of 3 × 3.5 × 4 cm. Examination of the did not revealed any further malformation, histology of parenchymal organs showed normal development. The placenta was of normal size and shape but an unusual membranous sac was attached to the fetal surface, marginally. It was connected with the umbilical cord with an amniotic band. Microscopical examination of the tumor revealed complex structure consisting of various tissues from the three germinal layers. Mature tissue types were represented by well differentiated respiratory and intestinal glands, skin with dermal appendages, islets of cartilage, renal glomeruli, smooth muscle fibers, and ganglion cells, scattered in mesenchymal tissue. Large amount of immature neural tissue was present. Malignant component was not detected. The tumor was diagnosed as a benign immature umbilical cord teratoma. In the course of ultrasonographic scanning umbilical cord teratoma might be suspected when a solid and cystic, rapidly growing lesion is seen, attached to the cord in midline location. When the tumor is surrounded by membranous structures and hiding in an omphalocele the narrowing of the cord between the tumor and the abdominal wall could be a useful sign.

P066: Prenatal sonographic measurement of the fetal iliac angle in trisomy 21, 18 and 13

OBJECTIVE To determine whether iliac wing angle measurement in second trimester fetuses is a useful sonographic marker for the detection of trisomy 21, 18 and 13. METHODS During the period between September 1998 and September 2001, 406 fetal iliac angle measurements were performed in women in the second trimester of their pregnancies. The iliac angle measurements in fetuses with trisomy 21 (n = 25), trisomy 18 (n = 10) and trisomy 13 (n = 5) were compared with iliac angle measurement in fetuses with normal karyotypes (n = 333). RESULTS The mean iliac wing angle in the fetuses with trisomy 21 was 92.67 and 79.35 degrees and 74 degrees in fetuses with trisomy 18 and 13 (the mean iliac wing angle in the healthy fetuses was 70.09 degrees ). CONCLUSION The proven larger iliac wing angle in neonates with Downs syndrome can be demonstrated sonographically during the pregnancy, especially during the second trimester, and may be useful in prenatal screening of trisomy 21. The sonographic measurement of the fetal iliac angle cannot be used as a marker for trisomy 18 and 13. We have shown that fetuses with trisomy 18 and 13, on average, have iliac angles only a few degrees larger than healthy fetuses.