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Dive into the research topics where Laszlo Jaszlits is active.

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Featured researches published by Laszlo Jaszlits.


Biochemical Pharmacology | 2002

BGP-15 — a novel poly(ADP-ribose) polymerase inhibitor — protects against nephrotoxicity of cisplatin without compromising its antitumor activity

Ildiko Racz; Kalman Tory; Ferenc Gallyas; Zoltán Berente; Erzsebet Osz; Laszlo Jaszlits; Sandor Bernath; Balazs Sumegi; Gyorgy Rabloczky; Peter Literati-Nagy

Nephrotoxicity is one of the major dose limiting side effects of cisplatin chemotherapy. The antitumor and toxic effects are mediated in part by different mechanisms, thus, permitting a selective inhibition of certain side effects. The influence of O-(3-piperidino-2-hydroxy-1-propyl)nicotinic amidoxime (BGP-15) - a poly(ADP-ribose) polymerase (PARP) inhibitor - on the nephrotoxicity and antitumor efficacy of cisplatin has been evaluated in experimental models. BGP-15 either blocked or significantly reduced (60-90% in 100-200 mg/kg oral dose) cisplatin induced increase in serum urea and creatinine level in mice and rats and prevented the structural degeneration of the kidney, as well. The nephroprotective effect of BGP-15 treatment was revealed also in living mice by MRI analysis manifesting in the lack of oedema which otherwise developed as a result of cisplatin treatment. The protective effect was accompanied by inhibition of cisplatin-induced poly-ADP-ribosylation and by the restoration of the disturbed energy metabolism. The preservation of ATP level in the kidney was demonstrated in vivo by localized NMR spectroscopy. BGP-15 decreased cisplatin-induced ROS production in rat kidney mitochondria and improved the antioxidant status of the kidney in mice with cisplatin-induced nephropathy. In rat kidney, cisplatin caused a decrease in the level of Bcl-x, a mitochondrial protective protein, and this was normalized by BGP-15 treatment. On the other hand, BGP-15 did not inhibit the antitumor efficacy of cisplatin in cell culture and in transplantable solid tumors of mice. Treatment with BGP-15 increased the mean survival time of cisplatin-treated P-388 leukemia bearing mice from 13 to 19 days. PARP inhibitors have been demonstrated to diminish the consequences of free radical-induced damage, and this is related to the chemoprotective effect of BGP-15, a novel PARP inhibitor. Based on these results, we propose that BGP-15 represents a novel, non-thiol chemoprotective agent.


General Pharmacology-the Vascular System | 2000

In vivo and in vitro acute cardiovascular effects of bimoclomol.

Andrea Jednakovits; Péter Ferdinandy; Laszlo Jaszlits; Tamás Bányász; János Magyar; Péter Szigligeti; Ágnes Körtvély; József A Szentmiklósi; Péter P. Nánási

Effects of bimoclomol, the novel heat shock protein (HSP) coinducer, was studied in various mammalian cardiac and rabbit aortic preparations. Bimoclomol decreased the ST-segment elevation induced by coronary occlusion in anesthetized dogs (56% and 80% reduction with 1 and 5 mg/kg, respectively). In isolated working rat hearts, bimoclomol increased coronary flow (CF), decreased the reduction of cardiac output (CO) and left ventricular developed pressure (LVDP) developing after coronary occlusion, and prevented ventricular fibrillation (VF) during reperfusion. In rabbit aortic preparations, precontracted with phenylephrine, bimoclomol induced relaxation (EC(50)=214 microM). Bimoclomol produced partial relaxation against 20 mM KCl, however, bimoclomol failed to relax preparations precontracted with serotonin, PGF(2) or angiotensin II. All these effects were evident within a few minutes after application of bimoclomol. A rapid bimoclomol-induced compartmental translocation of the already preformed HSPs may explain the protective action of the compound.


Nature Medicine | 1997

Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein- inducing activity and cytoprotective effects

László Vígh; Péter N. Literáti; Ibolya Horváth; Zsolt Török; Gábor Balogh; Attila Glatz; Eszter Kovács; Imre Boros; Péter Ferdinandy; Beatrix Farkas; Laszlo Jaszlits; Andrea Jednakovits; László Korányi; Bruno Maresca


Archive | 1996

Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof

Laszlo Vigh; Peter Literati Nagy; Jeno Szilbereky; László Ürögdi; Andrea Jednakovits; Laszlo Jaszlits; Katalin Biro; Ede Marvanyos; Mihaly Barabas; Erzsébet Hegedüs; Mária Kürthy; Gábor Balogh; Ibolya Horváth; Zsolt Török; Eva Udvardy; György Dormán; Denes Medzihradszky; Bea Mezes; Eszter Kovács; Erno Duda; Beatrix Farkas; Attila Glatz


Archive | 1987

Novel dihydropyridines having calcium antagonistic and antihypertensive activity

Geza Szilagyi; Eva Bozó; László Czollner; Laszlo Jaszlits; Gyorgy Rabloczky; Jozsef Borsi; Istvan Elekes; Gyongyi Nagy nee Csokas; Andras Varro; ZSuzanne Lang nee Rihmer; Gyorgy Cseh; Gyula Horváth; Ilona Bodi


Archive | 1978

3-(1-Pyrazolyl)-pyridazine derivatives

Geza Szilagyi; Endre Kasztreiner; Laszlo Tardos; Edit Kosa; Laszlo Jaszlits; Gyorgy Cseh; Andras Divald; Pal Tolnay; Sandor Elek; Istvan Elekes; Istvan Polgari


Archive | 1986

Aminoguanidine compounds, their compositions and pharmaceutical uses

Istvan Erczi; Jeno Marosfalvi; Gyorgy Rabloczky; Andras Varro; Maria Kuhar nee Kurthy; Istvan Elekes; Laszlo Szatmary; Laszlo Jaszlits


Archive | 1995

Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same

Mihaly Barabas; Ede Marvanyos; László Ürögdi; Laszlo Vereczkey; Laszlo Jaszlits; Katalin Biro; Andrea Jednakovits; Erzsebet Radvanyi; Istvanne Udvardy-Nagy


Archive | 1992

3(2H)-pyridazinone derivatives and process for the preparation thereof

Peter Matyus; Klára Czakó; Ildikó Varga; Andrea Jednakovics; Agnes Papp; Ilona Bodi; Gyorgy Rabloczky; Andras Varro; Laszlo Jaszlits; Aniko Nee Kovacs Miklos; Luca Nee Szalay Levay; Gvorgy Schmidt; Marton Fekete; Maria Kuhar nee Kurthy; Katalin Szemeredi; Erzsebet Zara


Archive | 1978

3-(1-Pyrazolyl)-pyridazine derivatives and hypotensive compositions thereof

Geza Szilagyi; Endre Kasztreiner; Laszlo Tardos; Edit Kosa; Laszlo Jaszlits; Gyorgy Cseh; Kovacs nee Szabo Ilona; Pal Tolnay; Sandor Elek; Istvan Elekes; Istvan Polgari

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Judit Kosary

Szent István University

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