Latonglila Jamir

A one-pot preparation of cyanamide from dithiocarbamate using molecular iodine

An efficient one-pot method for the synthesis of cyanamides from dithiocarbamate salts via a double desulfurization strategy using molecular iodine is disclosed. Dithiocarbamates, by the action of iodine yield isothiocyanates in situ, which on treatment with aqueous NH3 give thioureas. The thioureas so generated undergo further oxidative desulfurization with I2 giving corresponding cyanamides in good yields. Environmental benignity, cost effectiveness and high yields are the important attributes of this one pot procedure.

A one-pot strategy for the synthesis of 2-aminobenzothiazole in water by copper catalysis

A straightforward, efficient and sustainable method for the synthesis of 2-aminobenzothiazoles has been achieved from in situ generated 2-halothioureas using copper(I) catalyst in water. The present study demonstrates that copper iodide (CuI) exhibits better efficiency in water towards intramolecular S-arylation compared to organic solvents. While (o-iodoaryl) thioureas are smoothly converted to the desired product in high yields with only catalytic quantity of CuI, addition of base and ligand are essential for bromo and chloro analogues. An unprecedented demethoxylation of o-methoxy-o-iodoarylthiourea and demethoxylation followed by a Friedel–Crafts type methylation (para to nitrogen) was observed in the aryl ring possessing the original methoxy group.

Improved procedure for the preparation of isothiocyanates via iodine-mediated desulfurization of dithiocarbamic acid salts

Abstract We report here an improved procedure for the synthesis of isothiocyanates from the corresponding dithiocarbamic acid salts via a desulfurization strategy using molecular iodine and sodium bicarbonate in water/ethyl acetate biphasic medium. The reagents used are easily available, non-toxic, and cheap. High environmental acceptability of the reagents, cost effectiveness, and high yields are the important attributes of this methodology.

ENVIRONMENTALLY BENIGN ONE-POT SYNTHESIS OF CYANAMIDES FROM DITHIOCARBAMATES USING I2 AND H2O2

Abstract An environmentally benign reaction is devised for the synthesis of cyanamides from dithiocarbamate salts using iodine and H2O2. GRAPHICAL ABSTRACT

Synthesis and Reactivity Studies of a New Reagent, Ethyltriphenylphosphonium Tribromide

A new reagent, ethyltriphenyl phosphonium tribromide (ETPPTB), has been synthesized and studied. Results show that the reagent is quite efficient for various reactions such as organic bominations, acylations, and isothiocyanate preparation.

Microwave-induced reactions: an alternative route for chemical synthesis

In an effort to study the scope of microwave radiation for organic bromination reactions, some reactions were studied using a domestic microwave oven. Results reveal that these radiation-induced reactions are unique in their high yields and that they require extremely short reaction times compared with conventional room-temperature reactions. In these reactions tetrabutyl ammonium tribromide was used as an alternative brominating reagent in order to avoid the chemical hazards associated with liquid bromine (Br2). As all the reactions were successfully carried out in solid state under microwave conditions, the use of solvent was not required. All these aspects make the bromination protocol quite environment friendly.

Efficient one-pot preparation of bisalkyl xanthogen disulfides from alcohols

An efficient one-pot synthetic procedure for the preparation of bisalkyl xanthogen disulfides is achieved via oxidation of the in situ generated xanthate salt in an aqueous condition using half an equivalent of molecular iodine in one pot.

The oxidative cleavage of an anti-Hugerschoff product: a mild environmentally benign one pot synthesis of ureas from isothiocyanates

In a simple, one-pot procedure, H2O2 has been utilised for the synthesis of unsymmetrical ureas from thioureas obtained by the reaction of aryl isothiocyanates with aliphatic secondary amines. The reaction proceeds via the formation of a thioamido guanidino moiety (the anti-Hugerschoff product) which then undergoes further oxidative desulfurization in the presence of excess H2O2 to afford the desired product. The scope of this phosgene free urea synthesis has been extended to various substrates.