Laura Dawidowski

Age-related lung cell response to urban Buenos Aires air particle soluble fraction

Exposure to particulate matter (PM) may alter lung homeostasis inducing changes in fluid balance and host defense. Bioavailability of soluble PM compounds like polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and transition metals has been shown to play a key role in lung injury. We have previously characterized the size, shape, and chemical components of urban air particles from Buenos Aires (UAP-BA) and their biological impact on lungs. Herein, we evaluate the possible toxic effect of UAP-BA-soluble fraction (UAP-BAsf) on pulmonary cells obtained from young (1-2 months old) and aged (9-12 months old) Wistar rats using phagocytosis, oxidant-antioxidant generation, and apoptosis as endpoints. UAP-BA were collected in downtown BA and residual oil fly ash (ROFA), employed as a positive control, was collected from Boston Edison Co., Mystic Power Plant, Mystic, CT, USA. Both particle-soluble fractions (sf) were employed at concentrations ranging from 0 to 100 microg/mL. UAP-BAsf and ROFAsf even at the lowest dose assayed (10 microg/mL) showed in both lung cell populations the ability to stimulate phagocytosis and increase superoxide anion (O(2)(-)) generation. Both types of air particles caused a marked intracellular oxidant stress in aged pulmonary cells that may contribute to subsequent cell activation and production of proinflammatory mediators, leading to cell dysfunction. These data suggest that the impact of UAP-BAsf on phagocytosis, oxidant radical generation, and apoptosis is clearly dependent on the maturational state of the animal and might have different mechanisms of action.

Atmospheric pollution and mortality. A comparative study between two Latin American cities: Buenos Aires (Argentina) and Santiago (Chile)

This work aims to deepen recent studies on the impact of air pollution on human health in Latin American cities. A time series study has been performed comparing the mortality attributable to atmospheric carbon monoxide (CO) and nitrogen oxides (NOx) in Santiago (Chile) and Buenos Aires (Argentina). Pollution, meteorological and mortality data have been integrated in a general additive model (GAM) to establish the correlation between pollutant concentration levels and daily death counts. The analysis includes other variables such as gender, age and causes of death for each city with the result that both cities show increased deaths that can be attributed to an increase in CO and NOx levels. The impact is higher for Santiagos populations, for all the studied groups. This may be related to previous exposure to high pollution levels or to the co–presence of other pollutants not accounted for in this study.

Contaminación del aire en la Ciudad Autónoma de Buenos Aires: el riesgo de hoy o el cambio climático futuro, una falsa opción

Based on the theoretical framework of environmental risk, this article discusses the management of air quality in the Autonomous City of Buenos Aires in relation to current and potential impacts of toxic gases and global climate change on the health of the population. Information on historical and current management of the air was linked to the results of the South American Emissions, Megacities and Climate research project to assess danger, exposure, vulnerability and uncertainty as the dimensions of risk. By contextualizing public policies developed in recent decades on this subject, it was possible to identify emerging configurations of risk and uncertainties as accelerators of social vulnerability. On the one hand, the fact that there is a positive correlation between mortality, changes in temperature and air pollution was confirmed. On the other hand, it became clear that there is a disconnect between air quality management and health care management, while limitations were found in the proposed mitigation measures relating to emissions of greenhouse gases produced by fuel, revealing uncertainties regarding their efficacy.

Fostering a Collaborative Atmospheric Chemistry Research Community in the Latin America and Caribbean Region

AbstractIn 2013, the international Commission on Atmospheric Chemistry and Global Pollution (iCACGP) and the International Global Atmospheric Chemistry (IGAC) Project Americas Working Group (iCACGP/IGAC AWG) was formed to build a cohesive network and foster the next generation of atmospheric scientists with the goal of contributing to a scientific community focused on building collective knowledge for the Americas. The Latin America–Caribbean (LAC) region shares common history, culture, and socioeconomic issues but, at the same time, it is highly diverse in its physical and human geography. The LAC region is unique because approximately 80% of its population lives in urban areas, resulting in high-density hotspots of urbanization and vast unpopulated rural areas. In recent years, most countries of the region have experienced rapid growth in population and industrialization as their economies emerge. The rapid urbanization, the associated increases in mobile and industrial sources, and the growth of the ag...