Laura Dempere-Marco

CFD analysis incorporating the influence of wall motion: application to intracranial aneurysms

Haemodynamics, and in particular wall shear stress, is thought to play a critical role in the progression and rupture of intracranial aneurysms. A novel method is presented that combines image-based wall motion estimation obtained through non-rigid registration with computational fluid dynamics (CFD) simulations in order to provide realistic intra-aneurysmal flow patterns and understand the effects of deforming walls on the haemodynamic patterns. In contrast to previous approaches, which assume rigid walls or ad hoc elastic parameters to perform the CFD simulations, wall compliance has been included in this study through the imposition of measured wall motions. This circumvents the difficulties in estimating personalized elasticity properties. Although variations in the aneurysmal haemodynamics were observed when incorporating the wall motion, the overall characteristics of the wall shear stress distribution do not seem to change considerably. Further experiments with more cases will be required to establish the clinical significance of the observed variations.

Morphological Characterization of Intracranial Aneurysms Using 3-D Moment Invariants

Rupture of intracranial saccular aneurysms is the most common cause of spontaneous subarachnoid hemorrhage, which has significant morbidity and mortality. Although there is still controversy regarding the decision on which unruptured aneurysms should be treated, this is based primarily on their size. Nonetheless, many large lesions do not rupture whereas some small ones do. It is commonly accepted that hemodynamical factors are important to better understand the natural history of cerebral aneurysms. However, it might not always be practical to carry out a detailed computational analysis of such factors if a prompt assessment is required. Since shape is likely to be dependent on the balance between hemodynamic forces and the aneurysmal surrounding environment, an appropriate morphological 3-D characterization is likely to provide a practical surrogate to quickly evaluate the risk of rupture. In this paper, an efficient and novel methodology for 3-D shape characterization of cerebral aneurysms is described. The aneurysms are isolated by taking into account a portion of their adjacent vessels. Two methods to characterize the morphology of the aneurysms models using moment invariants have been considered: geometrical moment invariants (GMI) and Zernike moment invariants (ZMI). The results have been validated in a database containing 53 patients with a total of 31 ruptured aneurysms and 24 unruptured aneurysms. It has been found that ZMI indices are more robust than GMI, and seem to provide a reliable way to discriminate between ruptured and unruptured aneurysms. Correct rupture prediction rates of sime80% were achieved in contrast to 66% that is found when the aspect ratio index is considered.

Frequent Words Improve Readability and Short Words Improve Understandability for People with Dyslexia

Around 10% of the population has dyslexia, a reading disability that negatively affects a person’s ability to read and comprehend texts. Previous work has studied how to optimize the text layout, but adapting the text content has not received that much attention. In this paper, we present an eye-tracking study that investigates if people with dyslexia would benefit from content simplification. In an experiment with 46 people, 23 with dyslexia and 23 as a control group, we compare texts where words were substituted by shorter/longer and more/less frequent synonyms. Using more frequent words caused the participants with dyslexia to read significantly faster, while the use of shorter words caused them to understand the text better. Amongst the control group, no significant effects were found. These results provide evidence that people with dyslexia may benefit from interactive tools that perform lexical simplification.

Holding Multiple Items in Short Term Memory: A Neural Mechanism

Human short term memory has a capacity of several items maintained simultaneously. We show how the number of short term memory representations that an attractor network modeling a cortical local network can simultaneously maintain active is increased by using synaptic facilitation of the type found in the prefrontal cortex. We have been able to maintain 9 short term memories active simultaneously in integrate-and-fire simulations where the proportion of neurons in each population, the sparseness, is 0.1, and have confirmed the stability of such a system with mean field analyses. Without synaptic facilitation the system can maintain many fewer memories active in the same network. The system operates because of the effectively increased synaptic strengths formed by the synaptic facilitation just for those pools to which the cue is applied, and then maintenance of this synaptic facilitation in just those pools when the cue is removed by the continuing neuronal firing in those pools. The findings have implications for understanding how several items can be maintained simultaneously in short term memory, how this may be relevant to the implementation of language in the brain, and suggest new approaches to understanding and treating the decline in short term memory that can occur with normal aging.

Effective visual working memory capacity: an emergent effect from the neural dynamics in an attractor network.

The study of working memory capacity is of outmost importance in cognitive psychology as working memory is at the basis of general cognitive function. Although the working memory capacity limit has been thoroughly studied, its origin still remains a matter of strong debate. Only recently has the role of visual saliency in modulating working memory storage capacity been assessed experimentally and proved to provide valuable insights into working memory function. In the computational arena, attractor networks have successfully accounted for psychophysical and neurophysiological data in numerous working memory tasks given their ability to produce a sustained elevated firing rate during a delay period. Here we investigate the mechanisms underlying working memory capacity by means of a biophysically-realistic attractor network with spiking neurons while accounting for two recent experimental observations: 1) the presence of a visually salient item reduces the number of items that can be held in working memory, and 2) visually salient items are commonly kept in memory at the cost of not keeping as many non-salient items. Our model suggests that working memory capacity is determined by two fundamental processes: encoding of visual items into working memory and maintenance of the encoded items upon their removal from the visual display. While maintenance critically depends on the constraints that lateral inhibition imposes to the mnemonic activity, encoding is limited by the ability of the stimulated neural assemblies to reach a sufficiently high level of excitation, a process governed by the dynamics of competition and cooperation among neuronal pools. Encoding is therefore contingent upon the visual working memory task and has led us to introduce the concept of effective working memory capacity (eWMC) in contrast to the maximal upper capacity limit only reached under ideal conditions.

The influence of spatiotemporal structure of noisy stimuli in decision making.

Decision making is a process of utmost importance in our daily lives, the study of which has been receiving notable attention for decades. Nevertheless, the neural mechanisms underlying decision making are still not fully understood. Computational modeling has revealed itself as a valuable asset to address some of the fundamental questions. Biophysically plausible models, in particular, are useful in bridging the different levels of description that experimental studies provide, from the neural spiking activity recorded at the cellular level to the performance reported at the behavioral level. In this article, we have reviewed some of the recent progress made in the understanding of the neural mechanisms that underlie decision making. We have performed a critical evaluation of the available results and address, from a computational perspective, aspects of both experimentation and modeling that so far have eluded comprehension. To guide the discussion, we have selected a central theme which revolves around the following question: how does the spatiotemporal structure of sensory stimuli affect the perceptual decision-making process? This question is a timely one as several issues that still remain unresolved stem from this central theme. These include: (i) the role of spatiotemporal input fluctuations in perceptual decision making, (ii) how to extend the current results and models derived from two-alternative choice studies to scenarios with multiple competing evidences, and (iii) to establish whether different types of spatiotemporal input fluctuations affect decision-making outcomes in distinctive ways. And although we have restricted our discussion mostly to visual decisions, our main conclusions are arguably generalizable; hence, their possible extension to other sensory modalities is one of the points in our discussion.

A Novel Framework for the Analysis of Eye Movements during Visual Search for Knowledge Gathering

In this article, a conceptual framework developed to acquire expert knowledge from eye-tracking data of skilled individuals is presented. Domain-specific knowledge is acquired from the visual behaviour of subjects whose eye movements are recorded while solving complex visual tasks. It is argued that relevant insights into the cognitive strategies followed by the observers to solve the visual search tasks may be gained by analysing the eye-tracking data in generic feature spaces, which are at the basis of the selected scheme for knowledge representation. In this context, a feature space is a domain in which each dimension is defined as a mathematical construct, which may correspond to perceptually meaningful visual cues and which can take either numerical or categorical values. A special case of such feature spaces is the spatial domain in which the spatial coordinates of the gaze points define the dimensions of such domain. In the proposed conceptual framework, the definition of similarities between visual search patterns is essential to characterise the stereotypical visual behaviour of a group of observers, and thus expert knowledge. Furthermore, since knowledge representation is closely related to the feature domain in which the search is analysed, feature relevance measures become central to knowledge gathering, and the main aspects regarding their definition are discussed in this work. Following a detailed presentation of the conceptual framework, a practical application dealing with expert knowledge gathering in lung radiology is shown both as a proof of concept and also to illustrate a particular functional implementation of the framework.

Bayesian feature evaluation for visual saliency estimation

This paper presents a computational method of feature evaluation for modeling saliency in visual scenes. This is highly relevant in visual search studies since visual saliency is at the basis of visual attention deployment. Visual saliency can also become important in computer vision applications as it can be used to reduce the computational requirements by permitting processing only in those regions of the scenes containing relevant information. The method is based on Bayesian theory to describe the interaction between top-down and bottom-up information. Unlike other approaches, it evaluates and selects visual features before saliency estimation. This can reduce the complexity and, potentially, improve the accuracy of the saliency computation. To this end, we present an algorithm for feature evaluation and selection. A two-color conjunction search experiment has been applied to illustrate the theoretical framework of the proposed model. The practical value of the method is demonstrated with video segmentation of instruments in a laparoscopic cholecystectomy operation.

Characterization of cerebral aneurysms using 3D moment invariants

The rupture mechanism of intracranial aneurysms is still not fully understood. Although the size of the aneurysm is the shape index most commonly used to predict rupture, some controversy still exists about its adequateness as an aneurysm rupture predictor. In this work, an automatic method to geometrically characterize the shape of cerebral saccular aneurysms using 3D moment invariants is proposed. Geometric moments are efficiently computed via application of the Divergence Theorem over the aneurysm surface using a non-structured mesh. 3D models of the aneurysm and its connected parent vessels have been reconstructed from segmentations of both 3DRA and CTA images. Two alternative approaches have been used for segmentation, the first one based on isosurface deformable models, and the second one based on the level set method. Several experiments were also conducted to both assess the influence of pre-processing steps in the stability of the aneurysm shape descriptors, and to know the robustness of the proposed method. Moment invariants have proved to be a robust technique while providing a reliable way to discriminate between ruptured and unruptured aneurysms (Sensitivity=0.83, Specificity=0.74) on a data set containing 55 aneurysms. Further investigation over larger databases is necessary to establish their adequateness as reliable predictors of rupture risk.

A neurodynamical model of brightness induction in V1

Brightness induction is the modulation of the perceived intensity of an area by the luminance of surrounding areas. Recent neurophysiological evidence suggests that brightness information might be explicitly represented in V1, in contrast to the more common assumption that the striate cortex is an area mostly responsive to sensory information. Here we investigate possible neural mechanisms that offer a plausible explanation for such phenomenon. To this end, a neurodynamical model which is based on neurophysiological evidence and focuses on the part of V1 responsible for contextual influences is presented. The proposed computational model successfully accounts for well known psychophysical effects for static contexts and also for brightness induction in dynamic contexts defined by modulating the luminance of surrounding areas. This work suggests that intra-cortical interactions in V1 could, at least partially, explain brightness induction effects and reveals how a common general architecture may account for several different fundamental processes, such as visual saliency and brightness induction, which emerge early in the visual processing pathway.