Laura Heacock

Pulmonary Nodules in Patients with Primary Malignancy: Comparison of Hybrid PET/MR and PET/CT Imaging

PURPOSE To assess diagnostic sensitivity of radial T1-weighted gradient-echo (radial volumetric interpolated breath-hold examination [VIBE]) magnetic resonance (MR) imaging, positron emission tomography (PET), and combined simultaneous PET and MR imaging with an integrated PET/MR system in the detection of lung nodules, with combined PET and computed tomography (CT) as a reference. MATERIALS AND METHODS In this institutional review board-approved HIPAA-compliant prospective study, 32 patients with tumors who underwent clinically warranted fluorine 18 ((18)F) fluorodeoxyglucose (FDG) PET/CT followed by PET/MR imaging were included. In all patients, the thorax station was examined with free-breathing radial VIBE MR imaging and simultaneously acquired PET data. Presence and size of nodules and FDG avidity were assessed on PET/CT, radial VIBE, PET, and PET/MR images. Percentage of nodules detected on radial VIBE and PET images was compared with that on PET/MR images by using generalized estimating equations. Maximum standardized uptake value (SUVmax) in pulmonary nodules with a diameter of at least 1 cm was compared between PET/CT and PET/MR imaging with Pearson rank correlation. RESULTS A total of 69 nodules, including 45 FDG-avid nodules, were detected with PET/CT. The sensitivity of PET/MR imaging was 70.3% for all nodules, 95.6% for FDG-avid nodules, and 88.6% for nodules 0.5 cm in diameter or larger. PET/MR imaging had higher sensitivity than PET for all nodules (70.3% vs 61.6%, P = .002) and higher sensitivity than MR imaging for FDG-avid nodules (95.6% vs 80.0%, P = .008). There was a significantly strong correlation between SUVmax of pulmonary nodules obtained with PET/CT and that obtained with PET/MR imaging (r = 0.96, P < .001). CONCLUSION Radial VIBE and PET data acquired simultaneously with PET/MR imaging have high sensitivity in the detection of FDG-avid nodules and nodules 0.5 cm in diameter or larger, with low sensitivity for small non-FDG-avid nodules.

PET/MRI for the Evaluation of Patients With Lymphoma: Initial Observations

OBJECTIVE The objective of our study was to assess the role of recently introduced hybrid PET/MRI in the evaluation of lymphoma patients using PET/CT as a reference standard. SUBJECTS AND METHODS In this prospective study 28 consecutive lymphoma patients (18 men, 10 women; mean age, 53.6 years) undergoing clinically indicated PET/ CT were subsequently imaged with PET/MRI using residual FDG activity from the PET/ CT study. Blinded readers evaluated PET/CT (reference standard), PET/MRI, and diffusion-weighted imaging (DWI) studies separately; for each study, they assessed nodal and extranodal involvement. Each FDG-avid nodal station was marked and compared on DWI, PET/MRI, and PET/CT. Modified Ann Arbor staging was performed and compared between PET/MRI and PET/CT. The maximum standardized uptake value (SUVmax) on PET/MRI for FDG-avid nodal lesions was compared with the SUVmax on PET/CT. The apparent diffusion coefficient (ADC) for FDG-avid nodal lesions was compared to SUVmax on PET/MRI. RESULTS Fifty-one FDG-avid nodal groups were identified on PET/CT in 13 patients. PET/MRI identified 51 of these nodal groups with a sensitivity of 100%. DWI identified 32 nodal groups for a sensitivity of 62.7%. PET/MRI staging and PET/CT staging were concordant in 96.4% of patients. For the one patient with discordant staging results, disease was correctly upstaged to stage IV on the basis of the PET/MRI finding of bone marrow involvement, which was missed on PET/CT. DWI staging was concordant with PET/CT staging in 64.3% of the patients. The increased staging accuracy of PET/MRI relative to DWI was significant (p=0.004). SUVmax measured on PET/MRI and PET/CT showed excellent statistically significant correlation (r=0.98, p<0.001). There was a poor negative correlation between ADC and SUVmax (r=-0.036, p=0.847). CONCLUSION PET/MRI can be used to assess disease burden in lymphoma with sensitivity similar to PET/CT and can be a viable alternative for lymphoma staging and follow-up.

Evaluation of a known breast cancer using an abbreviated breast MRI protocol: Correlation of imaging characteristics and pathology with lesion detection and conspicuity

OBJECTIVE This study evaluates use of an abbreviated magnetic resonance imaging protocol with T2-weighted imaging in detecting biopsy-proven unifocal breast cancer. MATERIALS AND METHODS This is an institutional review board approved retrospective study of patients with biopsy-proven unifocal breast cancer (88% invasive; 12% in situ) undergoing magnetic resonance imaging. In three separate sessions, three breast imagers evaluated (1) T1-weighted non-contrast, post-contrast and post-contrast subtracted images, (2) T1-weighted images with clinical history and prior imaging, and (3) T1-weighted images and T2-weighted images with clinical history and prior imaging. Protocols were compared for cancer detection, reading time and lesion conspicuity. An independent breast radiologist retrospectively analyzed initial enhancement ratio of cancers and retrospectively reviewed lesion morphology and final pathology. RESULTS All 107 cancers were identified at first protocol by at least one reader; five cancers were missed by either one or two readers. One cancer was missed by one reader at protocols two and three. Mean percentage detection for protocol one was 97.8%; protocol two, 99.4%, protocol three, 99.4%. T2-weighted images did not alter cancer detection but increased lesion conspicuity for 2/3 readers. 3/5 missed lesions were low grade cancers. Initial enhancement ratio was positively associated with increasing tumor grade (p=0.031) and pathology (p=0.002). Reader interpretation time decreased and lesion conspicuity increased as initial enhancement ratio increased. CONCLUSION Abbreviated magnetic resonance imaging has high rate of detection for known breast cancer and short interpretation time. T2 weighted imaging increased lesion conspicuity without altering detection rate. Initial enhancement ratio correlated with invasive disease and tumor grade.

Outcome of small lung nodules missed on hybrid PET/MRI in patients with primary malignancy.

To assess outcomes of lung nodules missed on simultaneous positron emission tomography and magnetic resonance imaging (PET/MRI) compared to the reference standard PET and computed tomography (PET/CT) in patients with primary malignancy.

Comparison of conventional DCE-MRI and a novel golden-angle radial multicoil compressed sensing method for the evaluation of breast lesion conspicuity.

To compare a novel multicoil compressed sensing technique with flexible temporal resolution, golden‐angle radial sparse parallel (GRASP), to conventional fat‐suppressed spoiled three‐dimensional (3D) gradient‐echo (volumetric interpolated breath‐hold examination, VIBE) MRI in evaluating the conspicuity of benign and malignant breast lesions.

Developments in Breast Imaging: Update on New and Evolving MR Imaging and Molecular Imaging Techniques

This article reviews new developments in breast imaging. There is growing interest in creating a shorter, less expensive MR protocol with broader applicability. There is an increasing focus on and consideration for the additive impact that functional analysis of breast pathology have on identifying and characterizing lesions. These developments apply to MR imaging and molecular imaging. This article reviews evolving breast imaging techniques with attention to strengths, weaknesses, and applications of these approaches. We aim to give the reader familiarity with the state of current developments in the field and to increase awareness of what to expect in breast imaging.

Feasibility analysis of early temporal kinetics as a surrogate marker for breast tumor type, grade, and aggressiveness: Breast MRI Early Temporal Kinetics

Screening breast MRI has been shown to preferentially detect high‐grade ductal carcinoma in situ (DCIS) and invasive carcinoma, likely due to increased angiogenesis resulting in early initial uptake of contrast. As interest grows in abbreviated screening breast MRI (AB‐MRI), markers of early contrast washin that can predict tumor grade and potential aggressiveness are of clinical interest.

After the storm: eight unexpected benefits to radiology resident education at NYU Langone Medical Center after Hurricane Sandy.

Hurricane Sandy, the “super storm” of 2012, battered the East Coast from the evening of Monday, October 29, through Tuesday, October 30, 2012. Although millions of lives in the New England region were affected by the storm, the people living in the coastal areas of New Jersey and seaside boroughs of New York City suffered some of the most severe consequences of the storm. The wind, rain, flooding, and fire brought these communities to a standstill. In the midst of the storm, New York University (NYU) Langone Medical Center, Bellevue Hospital Center, and the Veterans Affairs New York Harbor Healthcare System Manhattan Campus, all located on the southern coast of the island of Manhattan, sustained catastrophic damage from oncein-a-century flooding and failed generators, which required the temporary relocation of patients, employees, and services. The medical staff and volunteers heroically effected the safe evacuation of hundreds of patients to nearby hospitals. Many NYU administrative and research facilities were also severely damaged. After the wind and rain ceased, our stunned community regrouped to assess the damage and begin the recovery efforts. Among the challenges our institution faced was ensuring the integrity of its graduate medical training programs while the hospitals were largely closed for inpatient clinical care. Most residency programs were forced to reassign

Abdominopelvic MRI for Lesion Characterization After Prior Imaging: Factors Associated With Likelihood of Added Value

OBJECTIVE The purpose of this article is to evaluate factors associated with the likelihood that abdominopelvic MRI examinations performed for characterization of lesions identified on other imaging modalities will provide information that adds value to patient management. MATERIALS AND METHODS One thousand one hundred thirty-two lesions in 863 patients undergoing MRI for further characterization after detection by an alternative imaging modality were identified. Reports of the MRI examinations and of previous studies were reviewed to classify cases in terms of patient-, examination-, and lesion-related factors. MRI reports were also classified in terms of measures reflecting inclusion of content with the potential to add value to patient management. Data were analyzed using logistic regression for correlated data. RESULTS MRI provided a definitive diagnosis in 79.2% (897/1132), upgraded the severity of the favored diagnosis in 5.3% (60/1132), downgraded the severity of the favored diagnosis in 34.5% (390/1132), and showed an absence of the suspected lesion in 12.1% (137/1132) of cases. Provision of a definitive diagnosis (most common in liver, kidney, gallbladder, bowel, myometrium, and adrenal gland) was significantly associated with the organ containing the lesion (p < 0.001). A change in severity of the favored diagnosis (most common after CT or PET/CT) and the absence of the suspected lesion (most common after PET/CT) were significantly associated with the prior imaging modality (p ≤ 0.001). Among the lesions that were upgraded in severity, 76.7% subsequently underwent intervention or change in medical management. CONCLUSION Abdominopelvic MRI examinations performed for further lesion characterization may affect clinical management in a high fraction of cases, the likelihood of which is influenced by factors related to the given examination.