Laura J. Jelinek
ZymoGenetics
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Publication
Featured researches published by Laura J. Jelinek.
Cell | 2001
Hal Blumberg; Darrell Conklin; Wenfeng Xu; Angelika Grossmann; Ty Brender; Susan Carollo; Maribeth Eagan; Don Foster; Betty A. Haldeman; Angie Hammond; Harald S. Haugen; Laura J. Jelinek; James D. Kelly; Karen Madden; Mark Maurer; Julia Parrish-Novak; Donna E. Prunkard; Shannon Sexson; Cindy A. Sprecher; Kim Waggie; James W. West; Theodore E. Whitmore; Lena Yao; Melanie K. Kuechle; Beverly A. Dale; Yasmin A. Chandrasekher
A structural, profile-based algorithm was used to identify interleukin 20 (IL-20), a novel IL-10 homolog. Chromosomal localization of IL-20 led to the discovery of an IL-10 family cytokine cluster. Overexpression of IL-20 in transgenic (TG) mice causes neonatal lethality with skin abnormalities including aberrant epidermal differentiation. Recombinant IL-20 protein stimulates a signal transduction pathway through STAT3 in a keratinocyte cell line, demonstrating a direct action of this ligand. An IL-20 receptor was identified as a heterodimer of two orphan class II cytokine receptor subunits. Both receptor subunits are expressed in skin and are dramatically upregulated in psoriatic skin. Taken together, these results demonstrate a role in epidermal function and psoriasis for IL-20, a novel cytokine identified solely by bioinformatics analysis.
Proceedings of the National Academy of Sciences of the United States of America | 2001
Wenfeng Xu; Scott R. Presnell; Julia Parrish-Novak; Wayne R. Kindsvogel; Steve Jaspers; Zhi Chen; Stacey R. Dillon; Zeren Gao; Teresa Gilbert; Karen Madden; Stacy Schlutsmeyer; Lena Yao; Theodore E. Whitmore; Yasmin A. Chandrasekher; Francis J. Grant; Mark Maurer; Laura J. Jelinek; Harold Storey; Ty Brender; Angie Hammond; Stavros Topouzis; Christopher H. Clegg; Donald C. Foster
IL-22 is an IL-10 homologue that binds to and signals through the class II cytokine receptor heterodimer IL-22RA1/CRF2–4. IL-22 is produced by T cells and induces the production of acute-phase reactants in vitro and in vivo, suggesting its involvement in inflammation. Here we report the identification of a class II cytokine receptor designated IL-22RA2 (IL-22 receptor-α 2) that appears to be a naturally expressed soluble receptor. IL-22RA2 shares amino acid sequence homology with IL-22RA1 (also known as IL-22R, zcytor11, and CRF2–9) and is physically adjacent to IL-20Rα and IFN-γR1 on chromosome 6q23.3–24.2. We demonstrate that IL-22RA2 binds specifically to IL-22 and neutralizes IL-22-induced proliferation of BaF3 cells expressing IL-22 receptor subunits. IL-22RA2 mRNA is highly expressed in placenta and spleen by Northern blotting. PCR analysis using RNA from various tissues and cell lines showed that IL-22RA2 was expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. In situ hybridization revealed the dominant cell types expressing IL-22RA2 were mononuclear cells and epithelium. Because IL-22 induces the expression of acute phase reactants, IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses.
Diabetes | 1996
Lars Hestbjerg Hansen; Niels Abrahamsen; Jörg Hager; Laura J. Jelinek; Wayne R. Kindsvogel; Philippe Froguel; Erica Nishimura
The pancreatic islet hormone, glucagon, stimulates hepatic glucose production and has also been shown to potentiate glucose-induced insulin secretion. Because glucagon is a key regulator of glucose homeostasis, its receptor, which mediates the actions of glucagon, was considered a candidate gene involved in the pathogenesis of NIDDM. We have previously reported that a single heterozygous missense mutation in exon 2 of the glucagon receptor gene, which changes a glycine to a serine (Gly40Ser), is associated with NIDDM in a French population. In the present study, the signaling properties of this mutant receptor were examined in baby hamster kidney cells and rat insulinoma cells (REV-5AH) stably transfected with either the wild type or Gly40Ser mutant human glucagon receptor cDNAs. Competition assays using 125 I-labeled glucagon were performed, and in both cell types, the Gly40Ser mutant receptor was found to bind glucagon with an approximately threefold lower affinity compared with the wild type receptor. In both cell types, the production of cAMP in response to glucagon was decreased in cells expressing the mutant receptor compared with those expressing the wild type. Finally, glucagon-stimulated insulin secretion by RIN cells expressing the mutant receptor was decreased such that the dose-response curve was shifted to the right in comparison to that obtained with cells expressing the wild type receptor. These results indicate that this single-point mutation located in the extracellular region of the glucagon receptor decreases the sensitivity of target tissues to glucagon.
Journal of Biological Chemistry | 2002
Julia Parrish-Novak; Wenfeng Xu; Ty Brender; Lena Yao; Crystal Jones; James W. West; Cameron S. Brandt; Laura J. Jelinek; Karen Madden; Patricia A. Mckernan; Donald C. Foster; Stephen R. Jaspers; Yasmin A. Chandrasekher
Archive | 2002
Mediate Unique; Biological Functions; Julia Parrish-Novak; Wenfeng Xu; Ty Brender; Lena Yao; Crystal Jones; James W. West; Cameron S. Brandt; Laura J. Jelinek; Karen Madden; Patricia A. Mckernan; Donald C. Foster; Stephen R. Jaspers; Yasmin A. Chandrasekher
Gene | 1994
Si Lok; Joseph L. Kuijper; Laura J. Jelinek; Janet M. Kramer; Theodore E. Whitmore; Cindy A. Sprecher; Shannon Mathewes; Francis J. Grant; Shaula H. Biggs; Gary B. Rosenberg; Paul O. Sheppard; Patrick J. O'Hara; Donald C. Foster; Wayne R. Kindsvogel
Archive | 1998
Paul O. Sheppard; Laura J. Jelinek; Theodore E. Whitmore; Hal Blumberg; Joyce M. Lehner
Archive | 1995
Wayne R. Kindsvogel; Laura J. Jelinek; Paul O. Sheppard; Francis J. Grant; Joseph L. Kuijper; Donald C. Foster; Si Lok; Patrick J. O'Hara
Archive | 1993
Wayne R. Kindsvogel; Laura J. Jelinek; Paul O. Sheppard; Francis J. Grant; Joseph L. Kuijper; Donald C. Foster; Si Lok; Patrick J. O'Hara
Molecular Medicine | 1997
James Lagasse; Laura J. Jelinek; Shannon Sexson; Cathy Lofton-Day; John F. Breininger; Paul O. Sheppard; Wayne R. Kindsvogel; William Hagopian