Lauren Klinker

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Curved surfaces, complex geometries, and time-dynamic deformations of the heart create challenges in establishing intimate, nonconstraining interfaces between cardiac structures and medical devices or surgical tools, particularly over large areas. We constructed large area designs for diagnostic and therapeutic stretchable sensor and actuator webs that conformally wrap the epicardium, establishing robust contact without sutures, mechanical fixtures, tapes, or surgical adhesives. These multifunctional web devices exploit open, mesh layouts and mount on thin, bio-resorbable sheets of silk to facilitate handling in a way that yields, after dissolution, exceptionally low mechanical moduli and thicknesses. In vivo studies in rabbit and pig animal models demonstrate the effectiveness of these device webs for measuring and spatially mapping temperature, electrophysiological signals, strain, and physical contact in sheet and balloon-based systems that also have the potential to deliver energy to perform localized tissue ablation.

Catheter-Based Systems With Integrated Stretchable Sensors and Conductors in Cardiac Electrophysiology

Established classes of high-performance electronics have driven advances in interventional biomedicine. However, the large size, planar geometry and stiff mechanical properties of standard conventional electronics employed in medical devices give rise to important integration challenges with soft biological tissue. Stretchable and flexible biointegrated electronics could improve treatment procedures across a broad range of applications, including cardiac, neural and endovascular therapies. Here we present novel mechanics, materials and integration strategies for this new class of bioelectronics onboard minimally invasive catheter based systems. Co-located arrays of sensors and actuators affixed to cardiac and angioplasty balloon catheters capture new sensory information during ablation procedures, offering physicians the ability to adjust placement and treatment intra-procedurally. New circuit topologies, enabled by stretchable electronics, also overcome long standing challenges associated with transmitting vast amounts of data through narrow catheter lumens, thus allowing for a large number of sensors to be multiplexed for mapping electrophysiological activity with high spatiotemporal resolution and with a minimal number of routing wires. We present representative examples that highlight the clinical significance of soft bio-integrated electronics, along with the mechanics and processes that enable this technology.

Rapid fabrication of silk films with controlled architectures via electrogelation

Current methods to produce silk films include casting and spin coating. Here we introduce a new method for the fabrication of silk films: electrogelation. Through use of a closed-loop anode, films with high surface smoothness and optical transparency are produced. Bending the electrode loop allows films with three-dimensional topologies to be formed, possessing thicknesses capable of descending into the submicron thin film regime.

Multifunctional Epidermal Sensor Systems with Ultrathin Encapsulation Packaging for Health Monitoring

Wearable sensors have the potential to enable longitudinal, objective health monitoring in patients with chronic diseases, including cardiac rhythm disorders, neurological and movement disorders, diabetes, and pain. However, conventional wearable devices are typically comprised of rigid, packaged electronics, which may compromise overall signal fidelity and wearer comfort during activities of daily living and sleep. In this chapter, we present recent advances in the development of thin and stretchable epidermal systems for biometric data measurements. These non-invasive epidermal systems are fully integrated with multiple sensors, an analog front end module, a radio for wireless communication , onboard flash memory, a rechargeable battery all encapsulated in a soft, stretchable and water-resistant silicone, and with an air permeable adhesive layer that interfaces with the human skin. The encapsulated system intimately couples with the skin at multiple locations on the body. We present results showing the potential of this technology to quantitatively assess bio-kinematics and electrophysiological signals. Finally, we provide perspectives on remaining challenges and opportunities to achieve clinical validation and commercial adoption of these technologies.

Multifunctional Epidermal Sensor Systemswith Ultrathin Encapsulation Packagingfor Health Monitoring

Wearable sensors have the potential to enable longitudinal, objective health monitoring in patients with chronic diseases, including cardiac rhythm disorders, neurological and movement disorders, diabetes, and pain. However, conventional wearable devices are typically comprised of rigid, packaged electronics, which may compromise overall signal fidelity and wearer comfort during activities of daily living and sleep. In this chapter, we present recent advances in the development of thin and stretchable epidermal systems for biometric data measurements. These non-invasive epidermal systems are fully integrated with multiple sensors, an analog front end module, a radio for wireless communication , onboard flash memory, a rechargeable battery all encapsulated in a soft, stretchable and water-resistant silicone, and with an air permeable adhesive layer that interfaces with the human skin. The encapsulated system intimately couples with the skin at multiple locations on the body. We present results showing the potential of this technology to quantitatively assess bio-kinematics and electrophysiological signals. Finally, we provide perspectives on remaining challenges and opportunities to achieve clinical validation and commercial adoption of these technologies.

Multifunctional Epidermal Sensor SystemsEpidermal Electronics Multifunctional Epidermal Sensor Systems with Ultrathin Encapsulation PackagingUltraThin Encapsulation Packaging for Health MonitoringMultifunctional Epidermal Sensor Systems

Wearable sensors have the potential to enable longitudinal, objective health monitoring in patients with chronic diseases, including cardiac rhythm disorders, neurological and movement disorders, diabetes, and pain. However, conventional wearable devices are typically comprised of rigid, packaged electronics, which may compromise overall signal fidelity and wearer comfort during activities of daily living and sleep. In this chapter, we present recent advances in the development of thin and stretchable epidermal systems for biometric data measurements. These non-invasive epidermal systems are fully integrated with multiple sensors, an analog front end module, a radio for wireless communication , onboard flash memory, a rechargeable battery all encapsulated in a soft, stretchable and water-resistant silicone, and with an air permeable adhesive layer that interfaces with the human skin. The encapsulated system intimately couples with the skin at multiple locations on the body. We present results showing the potential of this technology to quantitatively assess bio-kinematics and electrophysiological signals. Finally, we provide perspectives on remaining challenges and opportunities to achieve clinical validation and commercial adoption of these technologies.

Multifunctional Epidermal Sensor Systems Multifunctional Epidermal Sensor Systems with Ultrathin Encapsulation Packaging for Health Monitoring

Wearable sensors have the potential to enable longitudinal, objective health monitoring in patients with chronic diseases, including cardiac rhythm disorders, neurological and movement disorders, diabetes, and pain. However, conventional wearable devices are typically comprised of rigid, packaged electronics, which may compromise overall signal fidelity and wearer comfort during activities of daily living and sleep. In this chapter, we present recent advances in the development of thin and stretchable epidermal systems for biometric data measurements. These non-invasive epidermal systems are fully integrated with multiple sensors, an analog front end module, a radio for wireless communication , onboard flash memory, a rechargeable battery all encapsulated in a soft, stretchable and water-resistant silicone, and with an air permeable adhesive layer that interfaces with the human skin. The encapsulated system intimately couples with the skin at multiple locations on the body. We present results showing the potential of this technology to quantitatively assess bio-kinematics and electrophysiological signals. Finally, we provide perspectives on remaining challenges and opportunities to achieve clinical validation and commercial adoption of these technologies.

Multifunctional Epidermal Sensor SystemsEpidermal ElectronicsMultifunctional Epidermal Sensor Systemswith Ultrathin Encapsulation PackagingUltraThin Encapsulation Packagingfor Health MonitoringMultifunctional Epidermal Sensor Systems

Wearable sensors have the potential to enable longitudinal, objective health monitoring in patients with chronic diseases, including cardiac rhythm disorders, neurological and movement disorders, diabetes, and pain. However, conventional wearable devices are typically comprised of rigid, packaged electronics, which may compromise overall signal fidelity and wearer comfort during activities of daily living and sleep. In this chapter, we present recent advances in the development of thin and stretchable epidermal systems for biometric data measurements. These non-invasive epidermal systems are fully integrated with multiple sensors, an analog front end module, a radio for wireless communication , onboard flash memory, a rechargeable battery all encapsulated in a soft, stretchable and water-resistant silicone, and with an air permeable adhesive layer that interfaces with the human skin. The encapsulated system intimately couples with the skin at multiple locations on the body. We present results showing the potential of this technology to quantitatively assess bio-kinematics and electrophysiological signals. Finally, we provide perspectives on remaining challenges and opportunities to achieve clinical validation and commercial adoption of these technologies.

Bio-integrated systems with stretchable designs for skin-mounted wearable health monitoring

We present ultrathin, flexible and stretchable epidermal health monitoring devices that contain physiological sensors, an analog front end processor, a core microprocessor, flash memory module, rechargeable battery, and a wireless communication (Bluetooth low energy) module. The system is mechanically matched to the Youngs modulus of human skin and designed to record heart rate, electromyography signals, activity, respiration and sleep quality to facilitate continuous (electro-)physiological data recording outside of the hospital setting.