Laurence G. Wesson

Calcium and magnesium excretion during glucose and mercaptomerin diuresis in man

Abstract Calcium and magnesium excretion as well as sodium, chloride, and glucose excretion were studied by standard clearance methods during glucose and glucose plus mercaptomerin diuresis in man. Calcium and magnesium excretion fractions were positively correlated with sodium or chloride excretion. The slopes of the regression equations relating magnesium or calcium excretion fraction to sodium excretion were about 8.2 and 5.8 ml. per minute of divalent ion clearance per millimole per minute change in sodium excretion. No significant differences were noted between the slopes of calcium and magnesium regression curves. No correlation was noted between calcium or magnesium excretion fraction and the extent of the glucose osmotic diuresis, as estimated by glucose excretion, suggesting that glucose osmotic diuresis per se has little effect on calcium or magnesium excretion. At the dose of mercaptomerin employed, no specific mercurial depression of calcium or magnesium transport, as related to sodium or chloride excretion, was noted.

Effect of mercurial diuretics on maximal rate of renal glucose transport in man.

Summary Depression of Tmg was not observed in 15 patients free of cardiovascular or renal dysfunction 2 hours after intravenous administration of Thiomerin (2 ml) or Mercuhydrin (3 ml/hr).

Cardiovascular Changes Induced by Rapid Expansion of the Extracellular Fluid

Summary The intravenous infusion of 1100 to 1600 cc of a modified Lockes solution at rates of 140 to 220 cc/min. in dogs causes only a transient increase in venous and arterial pressure and pulse rate. These values usually return to control levels within half an hour. Plasma and blood volume as measured by changes in plasma protein concentration and hematocrit are increased markedly at first, but return to within 20% of control values 70 minutes after the infusion. These systemic changes do not coincide in time with the increase in filtration rate and renal plasma flow induced by such infusions, and it is concluded that the changes in renal function cannot be attributed to them.

Contamination of Commercial p-Aminohippuric Acid with p-Aminobenzoic Acid.

Summary P-aminobenzoic acid is rapidly absorbed from the gastrointestinal tract in dog and man while p-aminohippuric acid is poorly absorbed. One commercial lot (National Aniline No. 12322) of p-aminohippuric acid was found to be contaminated with 23% of p-aminobenzoic acid. None of the contaminated material, to our knowledge, has been marketed in ampouled form for clinical investigation and an adequate control is now being maintained on the purity of clinical material.