Lawrence M. Ward

Synchronous neural oscillations and cognitive processes

The central problem for cognitive neuroscience is to describe how cognitive processes arise from brain processes. This review summarizes the recent evidence that synchronous neural oscillations reveal much about the origin and nature of cognitive processes such as memory, attention and consciousness. Memory processes are most closely related to theta and gamma rhythms, whereas attention seems closely associated with alpha and gamma rhythms. Conscious awareness may arise from synchronous neural oscillations occurring globally throughout the brain rather than from the locally synchronous oscillations that occur when a sensory area encodes a stimulus. These associations between the dynamics of the brain and cognitive processes indicate progress towards a unified theory of brain and cognition.

Residual Inhibition Functions Overlap Tinnitus Spectra and the Region of Auditory Threshold Shift

Animals exposed to noise trauma show augmented synchronous neural activity in tonotopically reorganized primary auditory cortex consequent on hearing loss. Diminished intracortical inhibition in the reorganized region appears to enable synchronous network activity that develops when deafferented neurons begin to respond to input via their lateral connections. In humans with tinnitus accompanied by hearing loss, this process may generate a phantom sound that is perceived in accordance with the location of the affected neurons in the cortical place map. The neural synchrony hypothesis predicts that tinnitus spectra, and heretofore unmeasured “residual inhibition functions” that relate residual tinnitus suppression to the center frequency of masking sounds, should cover the region of hearing loss in the audiogram. We confirmed these predictions in two independent cohorts totaling 90 tinnitus subjects, using computer-based tools designed to assess the psychoacoustic properties of tinnitus. Tinnitus spectra and residual inhibition functions for depth and duration increased with the amount of threshold shift over the region of hearing impairment. Residual inhibition depth was shallower when the masking sounds that were used to induce residual inhibition showed decreased correspondence with the frequency spectrum and bandwidth of the tinnitus. These findings suggest that tinnitus and its suppression in residual inhibition depend on processes that span the region of hearing impairment and not on mechanisms that enhance cortical representations for sound frequencies at the audiometric edge. Hearing thresholds measured in age-matched control subjects without tinnitus implicated hearing loss as a factor in tinnitus, although elevated thresholds alone were not sufficient to cause tinnitus.

Supramodal and modality-specific mechanisms for stimulus-driven shifts of auditory and visual attention

Two experiments are described in which visual and/or auditory location precues preceded visual or auditory targets. Observers were required to judge the location of the targets. Conditions were such that involuntary, stimulus-driven attention shifts were the only ones likely to occur and give rise to cueing effects. It was found that visual precues affected response time to localize both visual targets and auditory targets but auditory precues affected only the time to localize auditory targets. Moreover, when visual and auditory cues conflicted, visual cues dominated in the visual task but were dominated by auditory cues in the auditory task. These results imply that involuntary stimulus-driven attention shifts might be controlled by a modality-specific mechanism for visual tasks, whereas stimulus-driven shifts of auditory attention are controlled by a supramodal mechanism. This asymmetry in attention control is consistent with the idea that attentional dominance in a multimodal experimental task depends on the relative performance possible in the modalities involved; in this case visual localization is more precise than auditory and so auditory cues may be ineffective in cueing visual location, while visual cues are effective in both modalities.

Involuntary Listening Aids Seeing: Evidence From Human Electrophysiology

It is well known that sensory events of one modality can influence judgments of sensory events in other modalities. For example, people respond more quickly to a target appearing at the location of a previous cue than to a target appearing at another location, even when the two stimuli are from different modalities. Such cross-modal interactions suggest that involuntary spatial attention mechanisms are not entirely modality-specific. In the present study, event-related brain potentials (ERPs) were recorded to elucidate the neural basis and timing of involuntary, cross-modal spatial attention effects. We found that orienting spatial attention to an irrelevant sound modulates the ERP to a subsequent visual target over modality-specific, extrastriate visual cortex, but only after the initial stages of sensory processing are completed. These findings are consistent with the proposal that involuntary spatial attention orienting to auditory and visual stimuli involves shared, or at least linked, brain mechanisms.

An event-related brain potential study of inhibition of return

Event-related brain potentials (ERPs) were recorded during two spatial-cuing experiments using nonpredictive cues. Our primary goal was to determine the electrophysiological consequences of inhibition of return (IOR). At long (>500 msec) cue—target intervals, subjects responded more slowly to targets that appeared at or near the cued location, relative to targets that appeared on the opposite side of fixation from the cue. This behavioral IOR effect was associated with cue-validity effects on several components of the target-elicited ERP waveforms. The earliest such effect was a smaller occipital PI on valid-cue trials, which we interpret as a PI reduction. The P2 component was also smaller on validcue trials, indicating that nonpredictive spatial cues influence multiple stages of information processing at long cue—target intervals. Both of these effects were observed when sensory interactions between cue and target were likely to be negligible, indicating that they were not caused by sensory refractoriness. A different effect of cue validity, the posterior negative difference, was found when sensory interactions were likely to be greatest, indicating that it could arise from sensory refractoriness.

Rhythms of Consciousness: Binocular Rivalry Reveals Large-Scale Oscillatory Network Dynamics Mediating Visual Perception

Consciousness has been proposed to emerge from functionally integrated large-scale ensembles of gamma-synchronous neural populations that form and dissolve at a frequency in the theta band. We propose that discrete moments of perceptual experience are implemented by transient gamma-band synchronization of relevant cortical regions, and that disintegration and reintegration of these assemblies is time-locked to ongoing theta oscillations. In support of this hypothesis we provide evidence that (1) perceptual switching during binocular rivalry is time-locked to gamma-band synchronizations which recur at a theta rate, indicating that the onset of new conscious percepts coincides with the emergence of a new gamma-synchronous assembly that is locked to an ongoing theta rhythm; (2) localization of the generators of these gamma rhythms reveals recurrent prefrontal and parietal sources; (3) theta modulation of gamma-band synchronization is observed between and within the activated brain regions. These results suggest that ongoing theta-modulated-gamma mechanisms periodically reintegrate a large-scale prefrontal-parietal network critical for perceptual experience. Moreover, activation and network inclusion of inferior temporal cortex and motor cortex uniquely occurs on the cycle immediately preceding responses signaling perceptual switching. This suggests that the essential prefrontal-parietal oscillatory network is expanded to include additional cortical regions relevant to tasks and perceptions furnishing consciousness at that moment, in this case image processing and response initiation, and that these activations occur within a time frame consistent with the notion that conscious processes directly affect behaviour.

An Empirical Study of Computer System Learning: Comparison of Co-Discovery and Self-Discovery Methods

This paper reports a study that examined two types of exploratory computer learning methods: self-discovery vs. co-discovery, the latter of which involves two users working together to learn a system. An experiment was conducted to compare these two methods and the results were interpreted within a mental model framework. Co-discovery subjects were better than self-discovery subjects at making inferences about the capability and extended functions of the system. Furthermore, while working by themselves after an initial period of learning, they performed better in a similar, though more complex task than the one they encountered at the learning phase. Process tracing analysis showed that self-discovery subjects focused more on surface structures, such as detailed physical actions, for implementing the task. On the other hand, co-discovery groups focused more on relating lower level actions to higher level goals. Therefore, co-discovery subjects had a better understanding of the relationships between the physical actions and goals, and hence formed mental models with higher inference potential than self-discovery subjects.

The effect of optical blur on visual-geometric illusions

Blur, due to optical aberrations in the eye, has been implicated in visual illusions for converging line arrays. Using 26 illusion variants, 2.5 diopters of optical blur was optically induced, resulting in increased illusory effects for the Poggendorff and several Mueller-Lyer variants, but not for the other configurations. Some limitations on conditions drawn from induced blur are discussed.

Stimulus information and sequential dependencies in magnitude estimation and cross-modality matching

Descriptive models of magnitude estimation and cross-modality matching derived from two different approaches to psychophysical judgment, the response ratio hypothesis and the fuzzy judgment approach, are compared. The two approaches emphasize different bodies of facts but both attempt to account for sequential dependencies in psychophysical judgments. Both models suggest a hierarchical multiple linear regression model for such data. Some of the predictions of the models are explored in the context of two experiments in which the amount of stimulus information available to subjects in magnitude estimation and cross-modality matching tasks is varied. The fuzzy judgment approach generally does better in explaining the form of such data.

The behavioral component in the meaning of places

Abstract How do people think about the physical setting in the world around them? Part of the answer to this question may be in terms of the behaviors that occur there. To explore peoples knowledge of behavior—place associations, twenty places (shown via color photographs) were assessed in five ways: (a) ratings of the places suitability for each of eleven behaviors, (b) ratings of the expected frequency of occurrence of the eleven behaviors, (c) free listings of reasons for going to each place, (d) free listings of activities-while-there and (e) free listings of activities associated with the place. Results showed that people can distinguish places on the basis of behaviors, that the behavioral component of place meaning is composed of distinct aspects, and that knowledge of behavior is related to a global, overall representation of a place.