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Leah L. Frye

Rensselaer Polytechnic Institute

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Featured researches published by Leah L. Frye.

Bioorganic & Medicinal Chemistry | 1997

The design, synthesis and transmembrane transport studies of a biomimetic sterol-based ion channel.

Anthony D. Pechulis; Richele J. Thompson; John P. Fojtik; Herbert M. Schwartz; Carol A. Lisek; Leah L. Frye

A model sterol-based ion channel was rationally designed and synthesized. The potential ion channel is comprised of a tartrate-derived crown ether to which six steroids are appended. Macromolecule 1a was incorporated into phospholipid vesicles and shown to facilitate the transmembrane transport of sodium and lithium ions using alkali metal NMR spectroscopy.

Archive | 1994

Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants

Leah L. Frye; Michael Zasloff; William A. Kinney; Robert M. Moriarty

Journal of Organic Chemistry | 1995

Synthesis of 24.xi.-Squalamine, an Anti-Infective Steroidal Polyamine

Anthony D. Pechulis; Frank H. Bellevue; Christopher L. Cioffi; Sean Trapp; John P. Fojtik; Anthony A. McKitty; William A. Kinney; Leah L. Frye

Journal of Organic Chemistry | 1992

Sulfonylation of organometallic reagents with arenesulfonyl fluorides : a simple one-step synthesis of sulfones

Leah L. Frye; Eileen L. Sullivan; Kevin P. Cusack; John M. Funaro

Archive | 1994

Steroid derivatives, pharmaceutical compositions containing them, and their pharmaceutical uses

Leah L. Frye; Michael Zasloff; William A. Kinney; Robert M. Moriarty; Delwood C. Collins

Archive | 1994

Method for treating infection using steroid based pharmaceutical compositions

Leah L. Frye; Michael Zasloff; William A. Kinney; Robert M. Moriarty; Delwood C. Collins

Archive | 1995

Method for inhibiting angiogenesis using squalamine and squalamine steroid derivatives

Leah L. Frye; Michael Zasloff; William A. Kinney; Robert M. Moriarty; Delwood C. Collins

Journal of Organic Chemistry | 1990

Synthesis of potential mechanism-based inactivators of lanosterol 14.alpha.-methyl demethylase

Leah L. Frye; Cecil H. Robinson

ChemInform | 2010

Synthesis of 24ξ-Squalamine, an Antiinfective Steroidal Polyamine.

Anthony D. Pechulis; F. H. Bellevue; C. L. Cioffi; S. G. Trapp; John P. Fojtik; A. A. Mckitty; W. A. Kinney; Leah L. Frye

Archive | 2002

Farmaceutisk anvendelse af steroidderivater

Leah L. Frye; Michael Zasloff; William A. Kinney; Moriarty Robert; Delwood C. Collins

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Michael Zasloff

Georgetown University Medical Center

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Robert M. Moriarty

University of Illinois at Chicago

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Anthony D. Pechulis

Rensselaer Polytechnic Institute

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John P. Fojtik

Rensselaer Polytechnic Institute

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A. A. Mckitty

Rensselaer Polytechnic Institute

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C. L. Cioffi

Rensselaer Polytechnic Institute

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Cecil H. Robinson

Johns Hopkins University School of Medicine

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Christopher L. Cioffi

Columbia University

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Eileen L. Sullivan

Rensselaer Polytechnic Institute

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F. H. Bellevue

Rensselaer Polytechnic Institute

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